Identification of HIV-1 epitopes that induce the synthesis of a R5 HIV-1 suppression factor by human CD4+ T cells isolated from HIV-1 immunized hu-PBL SCID mice

Clinical and Developmental Immunology

Volumn 12, Issue 4, 2005, Pages 235-242

  Yoshida, Atsushi ^a   Tanaka, Reiko ^a   Kodama, Akira ^a   Yamamoto, Naoki ^b   Ansari, Aftab A ^c   Tanaka, Yuetsu ^a  

^a UNIVERSITY OF THE RYUKYUS   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dendritic cells; HIV 1; HIV 1 suppression; Vaccination

Indexed keywords

EPITOPE; GAG PROTEIN; GAMMA INTERFERON; INTERLEUKIN 2; POL PROTEIN; VIF PROTEIN; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELL LINEAGE; COCULTURE; CULTURE MEDIUM; DENDRITIC CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; INTERFERON PRODUCTION; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SCID MOUSE; SUPERNATANT; SYNTHESIS; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIVIRAL AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DENDRITIC CELLS; EPITOPES; GROWTH INHIBITORS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MICE, SCID; VIRUS INACTIVATION;

EID: 30344456987     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1080/17402520500391557     Document Type: Article

References (41)

1. + T cells during primary immune responses. Proc Natl Acad Sci USA 100:15006-15010, Epub 2003 Dec 1.
2. Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A, Martin MA. 1986. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol 59:284-291.
3. + T-cell-deficient mice. J Virol 68:4700-4704.
4. Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM, Casazza JP, Koup RA, Picker LJ. 2001. Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: Relationship to viral load in untreated HIV infection. J Virol 75:11983-11991.
5. + cell non-cytolytic anti-HIV activity mediated by a novel cytokine. Res Immunol 145:653-658.
6. Butera ST, Pisell TL, Limpakarnjanarat K, Young NL, Hodge TW, Mastro TD, Folks TM. 2001. Production of a novel viral suppressive activity associated with resistance to infection among female sex workers exposed to HIV type 1. AIDS Res Hum Retroviruses 17:735-744.
7. Capobianchi MR, Abbate I, Antonelli G, Turriziani O, Dolei A, Dianzani F. 1998. Inhibition of HIV type 1 BaL replication by MIP-1α, MIP-1β, and RANTES in macrophages. AIDS Res Hum Retroviruses 14:233-240.
8. + T cells to the cytopathic effects of infection with human immunodeficiency virus type 1 strain LAI. J Virol 71:4436-4444.
9. + T cells. Nature 417:95-98.
10. +T-Cell antiviral factor. J Biol Chem 277:42352-42357.
11. Geiben-Lynn R, Kursar M, Brown NV, Addo MM, Shau H, Lieberman J, Luster AD, Walker BD. 2003. HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. J Biol Chem 278:1569-1574.
12. + T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421:852-856.
13. Kalams SA, Buchbinder SP, Rosenberg ES, Billingsley JM, Colbert DS, Jones NG, Shea AK, Trocha AK, Walker BD. 1999. Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection. J Virol 73:6715-6720.
14. Kaufmann DE, Bailey PM, Sidney J, Wagner B, Norris PJ, Johnston MN, Cosimi LA, Addo MM, Lichterfeld M, Altfeld M, Frahm N, Brander C, Sette A, Walker BD, Rosenberg ES. 2004. Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. J Virol 78:4463-4477.
15. Kinter AL, Ostrowski M, Goletti D, Oliva A, Weissman D, Gantt K, Hardy E, Jackson R, Ehler L, Fauci AS. 1996. HIV replication in CD4+ T cells of HIV-infected individuals is regulated by a balance between the viral suppressive effects of endogenous beta-chemokines and the viral inductive effects of other endogenous cytokines. Proc Natl Acad Sci USA 93:14076-14081.
16. Koyanagi Y, Miles S, Mitsuyasu RT, Merrill JE, Vinters HV, Chen IS. 1987. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms. Science 236:819-822.
17. Krowka JF, Stites DP, Jain S, Steimer KS, George-Nascimento C, Gyenes A, Barr PJ, Hollander H, Moss AR, Homsy JM, et al. 1989. Lymphocyte proliferative responses to human immunodeficiency virus antigens in vitro. J Clin Invest 83:1198-1203.
18. + T cells produce HIV-inhibitory cytokines and chemokines. J Clin Immunol 22:253-262.
19. Mackewicz CE, Craik CS, Levy JA. 2003. The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors. Proc Natl Acad Sci USA 100:3433-3438.
20. + T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol 68:8056-8063.
21. + T-cell depletion in HIV disease. Nature 410:974-979.
22. McMichael AJ, Rowland-Jones SL. 2001. Cellular immune responses to HIV. Nature 410:980-987.
23. + T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat Immunol 3:1061-1068.
24. + lymphoid dendritic cells. J Exp Med 189:1981-1986.
25. +T lymphocytes. Proc Natl Acad Sci USA 97:3382-3387.
26. Planz O, Ehl S, Furrer E, Horvath E, Brundler MA, Hengartner H, Zinkernagel RM. 1997. A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers. Proc Natl Acad Sci USA 94:6874-6879.
27. Rosenberg ES, Altfeld M, Poon SH, Phillips MN, Wilkes BM, Eldridge RL, Robbins GK, D'Aquila RT, Goulder PJ, Walker BD. 2000. Immune control of HIV-1 after early treatment of acute infection. Nature 407:523-526.
28. +T cell responses associated with control of viremia. Science 278:1447-1450.
29. Rossio JL, M T, Esser K, Suryanarayana DK, Schneider JW, Bess Jr, G M, Vasquez TA, Wiltrout E, Chertova MK, Grimes Q, Sattentau LO, Arthur LE, Henderson JD. 1998. Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins. J Virol 72:7992-8001.
30. Rowland-Jones S. 1999. HIV infection: Where have all the T cells gone? Lancet 354:5-7.
31. +, T-cell clones correlates with the clinical state of human immunodeficiency virus type 1 (HIV-1)-infected individuals and may be responsible for blocking infection with non-syncytium-inducing HIV-1 in vitro. J Virol 72:876-881.
32. Shedlock DJ, Shen H. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300:337-339.
33. Subramani S, Mulligan R, Berg P. 1981. Expression of the mouse dihydrofolate reductase complementary deoxyribonucleic acid in simian virus 40 vectors. Mol Cell Biol 1:854-864.
34. Sun JC, Bevan MJ. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300:339-342.
35. Van Coillie E, Van Damme J, Opdenakker G. 1999. The MCP/eotaxin subfamily of CC chemokines. Cytokine Growth Factor Rev 10:61-86.
36. Verani A, Lusso P. 2002. Chemokines as natural HIV antagonists. Curr Mol Med 2:691-702.
37. Wahren B, Morfeldt-Mansson L, Biberfeld G, Moberg L, Sonnerborg A, Ljungman P, Werner A, Kurth R, Gallo R, Bolognesi D. 1987. Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection. J Virol 61:2017-2023.
38. Wilson JD, Imami N, Watkins A, Gill J, Hay P, Gazzard B, Westby M, Gotch FM. 2000. Loss of CD4+T cell proliferative ability but not loss of human immunodeficiency virus type 1 specificity equates with progression to disease. J Infect Dis 182:792-798.
39. Yoshida A, Tanaka R, Murakami T, Takahashi Y, Koyanagi Y, Nakamura M, Ito M, Yamamoto N, Tanaka Y. 2003. Induction of protective immune responses against R5 human immunodeficiency virus type 1 (HIV-1) infection in hu-PBL-SCID mice by intrasplenic immunization with HIV-1-pulsed dendritic cells: Possible involvement of a novel factor of human CD4(+) T-cell origin. J Virol 77:8719-8728.
40. Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmasso EA, Fu S, Pham T, Mei J, Ho JJ, Zhang W, Lopez P, Ho DD. 2002. Contribution of human α-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 anti-viral factor. Science 298:995-1000.
41. Zhou P, Goldstein S, Devadas K, Tewari D, Notkins AL. 1997. Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: Inhibition of mRNA expression. Nat Med 3:659-664.