Effect of intravitreal dexamethasone on vitreous vancomycin concentrations in patients with suspected postoperative bacterial endophthalmitis

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 243, Issue 11, 2005, Pages 1186-1189

  Gan, Ivan M ^a   Ugahary, Luana C ^a   van Dissel, Jaap T ^b   van Meurs, Jan C ^a  

^a ROTTERDAM EYE HOSPITAL   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bacterial endophthalmitis; Intravitreal dexamethasone; Intravitreal vancomycin

Indexed keywords

DEXAMETHASONE; GENTAMICIN; PLACEBO; VANCOMYCIN;

ADULT; AGED; ARTICLE; BACTERIAL INFECTION; BACTERIUM CULTURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG HALF LIFE; DRUG TISSUE LEVEL; ENDOPHTHALMITIS; FEMALE; HUMAN; MALE; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VITREOUS BIOPSY; VITREOUS BODY;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BIOLOGICAL AVAILABILITY; DEXAMETHASONE; ENDOPHTHALMITIS; EYE INFECTIONS, BACTERIAL; FEMALE; GLUCOCORTICOIDS; HALF-LIFE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; VANCOMYCIN; VITREOUS BODY;

EID: 30344442664     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-005-1182-1     Document Type: Article

References (10)

1. Callegan MC, Engelbert M, Parke DW, Jett BD, Gilmore MS (2002) Bacterial endophthalmitis: Epidemiology, therapeutics, and bacterium-host interactions. Clin Microbiol Rev 15(1):111-124 10.1128/ CMR.15.1.111-124.2002
2. Das T, Jalali S, Gothwal VK, Sharma S, Naduvilath TJ (1999) Intravitreal dexamethasone in exogenous bacterial endophthalmitis: Results of a prospective randomised study. Br J Ophthalmol 83(9):1050-1055 10460774
3. de Gans J, van de Beek D (2002) Dexamethasone in adults with bacterial meningitis. N Engl J Med 347(20):1549-1556 10.1056/NEJMoa021334
4. Gan IM, van Dissel JT, Beekhuis WH, Swart W, Van Meurs JC (2001) Intravitreal vancomycin and gentamicin concentrations in patients with postoperative endophthalmitis. Br J Ophthalmol 85(11):1289-1293 10.1136/ bjo.85.11.1289
5. Jett BD, Jensen HG, Atkuri RV, Gilmore MS (1995) Evaluation of therapeutic measures for treating endophthalmitis caused by isogenic toxin-producing and toxin-nonproducing Enterococcus faecalis strains. Invest Ophthalmol Vis Sci 36(1):9-15 7822163
6. Kwak HW, D'Amico DJ (1992) Evaluation of the retinal toxicity and pharmacokinetics of dexamethasone after intravitreal injection. Arch Ophthalmol 110(2):259-266 1736876
7. Meredith TA, Aguilar HE, Drews C, Sawant A, Gardner S, Wilson LA, Grossniklaus HE (1996) Intraocular dexamethasone produces a harmful effect on treatment of experimental Staphylococcus aureus endophthalmitis. Trans Am Ophthalmol Soc 94:241-252 8981699
8. Park SS, Vallar RV, Hong CH, von Gunten S, Ruoff K, D'Amico DJ (1999) Intravitreal dexamethasone effect on intravitreal vancomycin elimination in endophthalmitis. Arch Ophthalmol 117(8):1058-1062 10448749
9. Shah GK, Stein JD, Sharma S, Sivalingam A, Benson WE, Regillo CD, Brown GC, Tasman W (2000) Visual outcomes following the use of intravitreal steroids in the treatment of postoperative endophthalmitis. Ophthalmology 107(3):486-489 10.1016/S0161-6420(99)00139-6
10. Smith MA, Sorenson JA, Smith C, Miller M, Borenstein M (1991) Effects of intravitreal dexamethasone on concentration of intravitreal vancomycin in experimental methicillin-resistant Staphylococcus epidermidis endophthalmitis. Antimicrob Agents Chemother 35(7):1298-1302 1929285