Substrate specificity of human hepatic Udp-glucuronosyltransferases

Methods in Enzymology

Volumn 400, Issue , 2005, Pages 46-57

  Burchell, Brian ^a   Lockley, David J ^a   Staines, Adam ^a   Uesawa, Yoshihiro ^a   Coughtrie, Michael W H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHOL; 2 AMINOBIPHENYL; AMINOPHENOL DERIVATIVE; AMITRIPTYLINE; BILIRUBIN; ETHINYLESTRADIOL; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; HYODEOXYCHOLIC ACID; MORPHINE; PARACETAMOL; PROPOFOL; PROTEIN GLUCURONOSYLTRANSFERASE 1A4; PROTEIN GLUCURONOSYLTRANSFERASE 1A6; PROTEIN GLUCURONOSYLTRANSFERASE 1A9; PROTEIN GLUCURONOSYLTRANSFERASE 2B7; TOLCAPONE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG GLUCURONIDATION; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 30144432574     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(05)00003-0     Document Type: Review

References (37)

1. Bosma P.J., Roy Chowdhury J., Bakker C., Gantla S., De Boer A., Oostra B.A., Lindhout D., Tytgat G.N.J., Jansen P.L.M., Oude Elferink R.P.J., and Roy Chowdhury N. The genetic basis of the reduced expression of bilirubin UDP-glucuronoysltransferase in Gilbert's syndrome N. Eng. J. Med. 333 1995 1171 1175
2. Burchell B. Studies on the purification of rat liver uridine diphosphate glucuronyltransferase Biochem. J. 161 1977 543 549
3. Burchell B. Genetic variation of human UDP-glucuronosyltransferase: Implications in disease and drug glucuronidation Am. J. Pharmacogen. 3 2003 37 52
4. Burchell B., McGurk K., Brierley C.H., and Clarke D.J UDP-glucuronosyltransferases F.P. Guengerich "Comprehensive Toxicology: Biotransformation" 1997 Pergamon/Elsevier Science Amsterdam
5. Burchell B., Soars M., Monaghan G., Cassidy A., Smith D., and Ethell B. Drug-mediated toxicity caused by genetic deficiency of UDP- glucuronosyltransferases Toxicol. Lett. 112-113 2000 333 340
6. Coughtrie M.W.H., Blair J.N.R., Hume R., and Burchell A. Improved preparation of hepatic microsomes for in vitro diagnosis of inherited disorders of the glucose-6-phosphatase system Clin. Chem. 37 1991 739 742
7. Coughtrie M.W.H., Blair J.N.R., Hume R., and Burchell A. Purification and properties of rat kidney UDP-glucuronosyltransferase Biochem. Pharmacol. 36 1987 245 251
8. Court M.H. Isoform-selective probe substrates for in vitro studies of human UDP-glucuronosyltransferases Methods Enzymol 400 7 2005 this volume.
9. Danoff T.M., Campbell D.A., McCarthy L.C., Lewis K.F., Repasch M.H., Saunders A.M., Spurr N.K., Purvis I.J., Roses A.D., and Xu C.F. A Gilbert's syndrome UGT1A1 variant confers susceptibility to tranilast-induced hyperbilirubinemia Pharmacogen. J. 4 2004 49 53
10. Dutton G.J. "Glucuronidation of Drugs and Other Compounds." 1980 CRC Press Boca Raton, FL
11. Ethell B.T., Anderson G.D., Beaumont K., Rance D.J., and Burchell B. A universal radiochemical high-performance liquid chromatographic assay for the determination of UDP-glucuronosyltransferase activity Anal. Biochem. 255 1998 142 147
12. Ethell B.T., Beaumont K., Rance D.J., and Burchell B. Use of cloned and expressed human UDP-glucuronosyltransferases for the assessment of human drug conjugation and identification of potential drug interactions Drug Metab. Dispos. 29 2001 48 53
13. Ethell B.T., Riedel J., Englert H., Jantz H., Oekonomopulos R., and Burchell B. Glucuronidation of HMR1098 in human microsomes: Evidence for the involvement of UGT1A1 in the formation of S-glucuronides Drug Metab. Dispos. 31 2003 1027 1034
14. Fournel-Gigleux S., Jackson M.R., Wooster R., and Burchell B. Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture FEBS Lett. 243 1989 119 122
15. Fournel-Gigleux S., Sutherland L., Sabolovic N., Burchell B., and Siest G. Stable expression of two human UDP-glucuronosyltransferase cDNAs in V79 cell cultures Mol. Pharmacol. 39 1991 177 183
16. Harding D., Fournel-Gigleux S., Jackson M.R., and Burchell B. Cloning and substrate specificity of a human phenol UDP-glucuronosytransferase expressed in COS-7 cells Proc. Natl. Acad. Sci. USA 85 1988 8381 8385
17. Jackson M.R., McCarthy L.R., Corser R.B., Barr G.C., and Burchell B. Cloning of cDNAs coding for rat hepatic microsomal UDP-glucuronyltransferases Gene 34 1985 147 153
18. Kaku T., Ogura K., Nishiyama T., Ohnuma T., Muro K., and Hiratsuka A. Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4 Biochem. Pharmacol. 67 2004 2093 2102
19. Krishnaswamy S., Duan S.X., von Moltke L.L., Greenblatt D.J., and Court M.H. Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6 Drug Metab. Dispos. 31 2003 133 139
20. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
21. Milne A.M., Burchell B., and Coughtrie M.W.H. Design of isoform-specific anti-UGT antibodies Drug Metab. Rev. 36 Suppl. 1 2004 130
22. Milne A.M., Burchell B., and Coughtrie M.W.H. Quantification of UDP-glucuronosyltransferase expression in human tissues Drug Metab. Rev. 36 Suppl. 1 2004 130
23. Monaghan G., Ryan M., Seddon R., Hume R., and Burchell B. Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome Lancet 347 1996 578 581
24. Mulder G.J. The heterogeneity of uridine diphosphate glucuronyltransferase from rat liver Biochem. J. 125 1971 9 15
25. Owens I.S., Basu N.B., and Banerjee R. Gene structures of UGT1 and UGT2 families Methods Enzymol. 400 1 2005 this volume.
26. Sanchez E., and Tephly T.R. Evidence for separate enzymes in the glucuronidation of morphine and p-nitrophenol by rat hepatic microsomes Drug Metab. Dispos. 2 1974 247 253
27. Soars M.G., Riley R.J., and Burchell B. Evaluation of the marmoset as a model species for drug glucuronidation Xenobiotica 31 2001 849 860
28. Soars M.G., Riley R.J., Findlay K.A.B., Coffey M.J., and Burchell B. Evidence for significant differences in microsomal drug glucuronidation by canine and human liver and kidney Drug Metab. Dispos. 29 2001 121 126
29. Staines A.G., Coughtrie M.W.H., and Burchell B. N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7 J. Pharmacol. Exp. Ther. 311 2004 1131 1137
30. Staines A.G., Sindelar P., Coughtrie M.W.H., and Burchell B. Farnesol is glucuronidated in human liver, kidney and intestine in vitro, and is a novel substrate for UGT2B7 and UGT1A1 Biochem. J. 384 2004 637 645
31. Stone A.N., Mackenzie P.I., Galetin A., Houston J.B., and Miners J.O. Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7 Drug Metab. Dispos. 31 2003 1086 1089
32. Tukey R.H., and Strassburg C.P. Human UDP-glucuronosyltransferases: Metabolism, expression and disease Annu. Rev. Pharmacol. Toxicol. 40 2000 581 616
33. Uesawa Y., Staines A.G., O'Sullivan A., Mohri K., and Burchell B. Identification of the rabbit liver UDP-glucuronosyltransferase catalyzing the glucuronidation of 4-ethoxyphenylurea (dulcin) Drug Metab. Dispos. 32 2004 1476 1481
34. Watanabe Y., Nakajima M., Ohashi N., Kume T., and Yokoi T. Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1 Drug Metab. Dispos. 31 2003 589 595
35. Weatherill P.J., and Burchell B. The separation and purification of rat liver UDP glucuronyltransferase activities towards testosterone and oestrone Biochem. J. 189 1980 377 380
36. Williams J.A., Hyland R., Jones B.C., Smith D.A., Hurst S., Goosen T.C., Peterkin V., Koup J.R., and Ball S.E. Drug-drug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios Drug Metab. Dispos. 32 2004 1201 1208
37. Wooster R., Sutherland L., Ebner T., Clarke D., Da Cruz e Silva O., and Burchell B. Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family Biochem. J. 278 1991 465 469