Delivery of the p53 tumor suppressor gene into lung cancer cells by an adenovirus/DNA complex

Cancer Gene Therapy

Volumn 4, Issue 3, 1997, Pages 191-198

  Nguyen, Dao M ^a   Wiehle, Sandra A ^a   Koch, Patricia E ^a   Branch, Cynthia ^a   Yen, Nancy ^a   Roth, Jack A ^a   Cristiano, Richard J ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Adenovirus PLL DNA complex; p53 tumor suppressor gene

Indexed keywords

RECOMBINANT DNA;

ADENOVIRUS; ANIMAL; APOPTOSIS; ARTICLE; CANCER TRANSPLANTATION; CELL CULTURE; CELL DIVISION; EXPERIMENTAL NEOPLASM; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MOUSE; NUDE MOUSE; PATHOLOGY; TUMOR SUPPRESSOR GENE;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DIVISION; DNA, RECOMBINANT; FEMALE; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, P53; GENETIC VECTORS; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; TUMOR CELLS, CULTURED;

EID: 0031133029     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Blaese M, Blankenstein T, Brenner M, et al. Vectors in cancer therapy: how will they deliver? Cancer Gene Ther. 1995;2:291-297.
2. Zhu N, Liggitt D, Liu YL, Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science. 1993;261:209-211.
3. Stewart MT, Plautz GE, del Buono L, et al. Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice. Hum Gene Ther. 1992;3:267-275.
4. Cristiano RJ, Smith LC, Kay MA, Brinkley BR, Woo SLC. Hepatic gene therapy: efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adeno-virus-DNA complex. Proc Natl Acad Sci USA. 1993;90: 11548-11552.
5. Cristiano RJ, Roth JA. Molecular conjugates: a targeted gene delivery vector for molecular medicine. J Mol Med. 1995;73:479-486.
6. Curiel DT, Wagner E, Cotten M, et al. High-efficiency gene transfer mediated by adenovirus coupled to DNA-polylysine complexes. Hum Gene Ther. 1992;3:147-154.
7. Wagner E, Cotten M, Foisner R, Birnstiel ML. Transferin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells. Proc Natl Acad Sci USA. 1991;88:4255-4259.
8. Curiel DT, Agarwal S, Wagner E, Gotten M. Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc Natl Acad Sci USA. 1994;88:8850-8854.
9. Wagner E, Zatloukal K, Cotten M, et al. Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc Natl Acad Sci USA. 1992;89:6099-6103.
10. Wu GY, Zhan P, Sze LL, Resenberg AR, Wu CH. Incorporation of adenovirus into a ligand-base DNA carrier system results in retention or original receptor specificity and enhances targeted gene expression. J Biochem. 1994;269:11542-11546.
11. Nguyen DM, Wiehle SA, Roth JA, Cristiano RJ. Gene delivery into malignant cells by a conjugated adenovirus/ DNA complex. Cancer Gene Ther. 1997;4:183-190.
12. Falzon M, McMahon JB, Gazdar AF, Schuller HM. Preferential metabolism of N-nitrosodiethylamine by two cell lines derived from human pulmonary adenocarcinomas. Carcinogenesis. 1986;7:17-22.
13. Jones N, Shenk T. An adenovirus type 5 early gene function regulates expression of other early viral genes. Proc Natl Acad Sci USA. 1979;76:3665-3669.
14. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
15. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science. 1991;253:49-53.
16. Takahashi T, Nau MM, Chiba I, et al. p53: a frequent target for genetic abnormalities in lung cancer. Science. 1989;246:491-494.
17. Liu TJ, El-Naggar AK, Mcdonnell TJ, et al. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res. 1995;55:3117-3122.
18. Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA. 1992;89:4495-4499.
19. Wang J, Bucana CD, Roth JA, Zhang WW. Apoptosis induced in human osteosarcoma cells is one of the mech-anisms for the cytocidal effect of Ad5CMV-p53. Cancer Gene Ther. 1995;2:9-17.
20. Zhang WW, Fang X, Mazur W, French BA, Georges RN, Roth JA. High-efficiency gene transfer and highlevel expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther. 1994;1:5-13.
21. Wills KN, Maneval DC, Menzel P, et al. Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer. Hum Gene Ther. 1994;5:1079-1088.
22. Cai DW, Mukhopadhyay T, Liu YJ, Fujiwara T, Roth JA. Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer. Hum Gene Ther. 1993;4:617-624.
23. Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, White E. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci USA. 1992;89:7742-7746.
24. Debbas M, White E. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 1993;7:546-554.
25. Dobner T, Horikoshi N, Rubenwolf S, Shenk T. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science. 1996;272:1470-1473.
26. Cotton M, Wagner E, Zatloukal K, Phillips S, Curiel DT, Birnstiel ML. High-efficiency receptor-mediated delivery of small and large (48 kilobase) gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles. Proc Natl Acad Sci USA. 1992;89:6094-6098.
27. Morgan DM, Larvin VL, Pearson JD. Biochemical characterization of polycation-induced cytotoxicity to human vascular endothelial cells. J Cell Sci. 1989;94:553-559.
28. Gao L, Wagner E, Cotten M, et al. Direct in vivo gene transfer to airway epithelium employing adenovirus-polylysine-DNA complexes. Hum Gene Ther. 1993;4:17-23.