Signaling via the angiotensin-converting enzyme results in the phosphorylation of the nonmuscle myosin heavy chain IIA

Molecular Pharmacology

Volumn 69, Issue 1, 2006, Pages 19-26

  Kohlstedt, Karin ^a   Kellner, Roland ^b   Busse, Rudi ^a   Fleming, Ingrid ^a  

^a GOETHE UNIVERSITY   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MYOSIN IIA; SERINE;

ARTICLE; CELL MEMBRANE; CELL STIMULATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CELLS, CULTURED; COLCHICINE; CYTOCHALASIN D; CYTOSKELETAL PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPRECIPITATION; MOLECULAR MOTOR PROTEINS; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; MYOSIN HEAVY CHAINS; PEPTIDYL-DIPEPTIDASE A; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 30044434895     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.016733     Document Type: Article

References (32)

1. Allinson TMJ, Parkin ET, Condon TP, Schwager SLU, Sturrock ED, Turner AJ, and Hooper NM (2004) The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein. Eur J Biochem 271:2539-2547.
2. Berg JS, Powell BC, and Cheney RE (2001) A millennial myosin census. Mol Biol Cell 12:780-794.
3. Bren GD, Pennington KN, and Paya CV (2000) PKC-ζ-associated CK2 participates in the turnover of free IκBα. J Mol Biol 297:1245-1258.
4. Brzeska H and Korn ED (1996) Regulation of class I and class II myosins by heavy chain phosphorylation. J Biol Chem 271:16983-16986.
5. Busse R and Lamontagne D (1991) Endothelium-derived bradykinin is responsible for the increase in calcium produced by angiotensin-converting enzyme inhibitors in human endothelial cells. Naunyn-Schmiedeberg's Arch Pharmacol 344:126-129.
6. Cambien F, Costerousse O, Tiret L, Poirier O, Lecerf L, Gonzales MF, Evans A, Arveiler D, Cambou JP, Luc G, et al. (1994) Plasma level and gene polymorphism of angiotensin-converting enzyme in relation to myocardial infarction. Circulation 90:669-676.
7. Chubb AJ, Schwager SL, van der Merwe E, Ehlers MR, and Sturrock ED (2004) Deletion of the cytoplasmic domain increases basal shedding of angiotensin-converting enzyme. Biochem Biophys Res Commun 314:971-975.
8. Conti MA, Sellers JR, Adelstein RS, and Elzinga M (1991) Identification of the serine residue phosphorylated by protein kinase C in vertebrate nonmuscle myosin heavy chains. Biochemistry 30:966-970.
9. Dzau VJ, Bernstein K, Celermajer D, Cohen J, Dahlof B, Deanfield J, Diez J, Drexler H, Ferrari R, Van Gilst W, et al. (2002) Pathophysiologic and therapeutic importance of tissue ACE: a consensus report. Cardiovasc Drugs Ther 16:149-160.
10. 2+-independent activation of the endothelial nitric oxide synthase in response to tyrosine phosphatase inhibitors and fluid shear stress. Circ Res 82:686-695.
11. Hathaway GM and Traugh JA (1982) Casein kinases-multipotential protein kinases. Curr Top Cell Regul 21:101-127.
12. Jaspard E, Costerousse O, Wei L, Corvol P, and Alhenc-Gelas F (1992) The angiotensin I-converting enzyme (kininase II): molecular and regulatory aspects. Agents Actions Suppl 38:349-358.
13. Kohlstedt K, Brandes RP, Muller-Esterl W, Busse R, and Fleming I (2004) Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res 94:60-67.
14. Kohlstedt K, Shoghi F, Müller-Esterl W, Busse R, and Fleming I (2002) CK2 phosphorylates the angiotensin-converting enzyme and regulates its retention in the endothelial cell plasma membrane. Circ Res 91:749-756.
15. Kolega J (1998) Cytoplasmic dynamics of myosin IIA and IIB: spatial 'sorting' of isoforms in locomoting cells. J Cell Sci 111:2085-2095.
16. Kramers C, Danilov SM, Deinum J, Balyasnikova IV, Scharenborg N, Looman M, Boomsma F, de Keijzer MH, van Duijn C, Martin S, et al. (2001) Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease. Circulation 104:1236-1240.
17. Kumar RS, Thekkumkara TJ, and Sen GC (1991) The mRNAs encoding the two angiotensin-converting isozymes are transcribed from the same gene by a tissue-specific choice of alternative transcription initiation sites. J Biol Chem 266:3854-3862.
18. Murakami N, Chauhan VP, and Elzinga M (1998) Two nonmuscle myosin II heavy chain isoforms expressed in rabbit brains: filament forming properties, the effects of phosphorylation by protein kinase C and casein kinase II and location of the phosphorylation sites. Biochemistry 37:1989-2003.
19. Murakami N, Healy-Louie G, and Elzinga M (1990) Amino acid sequence around the serine phosphorylated by casein kinase II in brain myosin heavy chain. J Biol Chem 265:1041-1047.
20. Oosterga M, Voors AA, de Kam PJ, Schunkert H, Pinto YM, Kingma JH, and van Gilst WH (1997) Plasma angiotensin-converting enzyme activity and left ventricular dilation after myocardial infarction. Circulation 95:2607-2609.
21. Ramchandran R, Sen GC, Misono K, and Sen I (1994) Regulated cleavage-secretion of the membrane-bound angiotensin- converting enzyme. J Biol Chem 269:2125-2130.
22. Rieker JP, Swanljung-Collins H, Montibeller J, and Collins JH (1987) Brush border myosin heavy chain phosphorylation is regulated by calcium and calmodulin. FEBS Lett 212:154-158.
23. Sajid M, Hu Z, Lele M, and Stouffer GA (2000) Protein complexes involving αvβ3 integrins, nonmuscle myosin heavy chain-A and focal adhesion kinase from in thrombospondin-treated smooth muscle cells. J Investig Med 48:190-197.
24. Santhamma KR, Sadhukhan R, Kinter M, Chattopadhyay S, McCue B, and Sen I (2004) Role of tyrosine phosphorylation in the regulation of cleavage secretion of angiotensin-converting enzyme. J Biol Chem 279:40227-40236.
25. Santhamma KR and Sen I (2000) Specific cellular proteins associate with angiotensin-converting enzyme and regulate its intracellular transport and cleavage-secretion. J Biol Chem 275:23253-23258.
26. Simons M, Wang M, McBride OW, Kawamoto S, Yamakawa K, Gdula D, Adelstein RS, and Weir L (1991) Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomes. Circ Res 69:530-539.
27. Suarez-Huerta N, Lecocq R, Mosselmans R, Galand P, Dumont JE, and Robaye B (2000) Myosin heavy chain degradation during apoptosis in endothelial cells. Cell Prolif 33:101-114.
28. van Esch JHM, Tom B, Dive V, Batenburg WW, Georgiadis D, Yiotakis A, van Gool JMG, de Bruijn RJA, de Vries R, and Danser AHJ (2005) Selective angiotensin-converting enzyme C-domain inhibition is sufficient to prevent angiotensin I-induced vasoconstriction. Hypertension 45:120-125.
29. van Leeuwen FN, van Delft S, Kain HE, van der Kammen RA, and Collard JG (1999) Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading. Nat Cell Biol 1:242-248.
30. 2+-dependent threonine phosphorylation of myosin heavy chain in rat pancreatic islets and RINm5F cells. J Biol Chem 273:22729-22737.
31. World Medical Association Declaration of Helsinki (1997) Recommendations guiding physicians in biomedical research involving human subjects. Cardiovasc Res 35:2-3.
32. Xiao HD, Fuchs S, Frenzel K, Teng L, and Bernstein KE (2004) Circulating versus local angiotensin II in blood pressure control: lessons from tissue-specific expression of angiotensin-converting enzyme (ACE). Crit Rev Eukaryot Gene Expr 14:137-145.