Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

Annals of Neurology

Volumn 59, Issue 1, 2006, Pages 21-26

  Smemo, Scott ^a   Nowotny, Petra ^a   Hinrichs, Anthony L ^a   Kauwe, John S K ^a   Cherny, Sara ^a   Erickson, Katherine ^a   Myers, Amanda J ^b   Kaleem, Mona ^b   Marlowe, Lauren ^b   Gibson, Alison M ^c   Hollingworth, Paul ^d   O'Donovan, Michael C ^d   Morris, Chris M ^a   Holmans, Peter ^d   Lovestone, Simon ^e   Morris, John C ^a   Thal, Leon ^f   Li, Yonghong ^g   Grupe, Andrew ^g   Hardy, John ^b   Owen, Michael J ^d   Williams, Julie ^d   Goate, Alison ^a   more..

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b National Institute for Aging   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g CELERA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; UBIQUILIN 1; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; ARTICLE; CHROMOSOME 9; CONTROLLED STUDY; EXON; FEMALE; GENE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HUMAN; HUMAN TISSUE; INTRON; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UBQLN1 GENE;

ALZHEIMER DISEASE; CARRIER PROTEINS; CELL CYCLE PROTEINS; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 29944443356     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.20673     Document Type: Article

References (22)

1. Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 1993;90:1977-1981.
2. Warwick Daw E, Payami H, Nemens EJ, et al. The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet 2000;66:196-204.
3. Blacker D, Bertram L, Saunders AJ, et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum Mol Genet 2003;12:23-32.
4. Myers A, Wavrant-De Vrieze F, Holmans P, et al. Full genome Screen for Alzheimer disease: stage II analysis. Am J Med Genet 2002;114:235-244.
5. Mah AL, Perry G, Smith MA, et al. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol 2000;151:847-862.
6. Massey LK, Mah AL, Ford DL, et al. Overexpression of ubiquilin decreases ubiquitination and degradation of presenilin proteins. J Alzheimers Dis 2004;6:79-92.
7. Sherrington R, Rogaev EI, Liang Y, et al. Cloning a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 1995;375:754-760.
8. Levy-Lahad E, Wasco W, Poorkaj P, et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995;269:973-977.
9. Bertram L, Hiltunen M, Parkinson M, et al. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med 2005;352:884-894.
10. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
11. Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol Aging 1997;18:351-357.
12. Nowotny P, Hinrichs AI, Smemo S, et al. Association studies between the risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. Am J Med Genet 2005;136:62-68.
13. Pittman AM, Myers AJ, Abou-Sleiman P, et al. Linkage disequilibrium fine-mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration. J Med Genet 2005; Online ahead of print. DOI: 10.1136/jmg.2005.031377.
14. Germer S, Holland MJ, Higuchi R. High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. Genome Res 2000;10:258-266.
15. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003;25:115-121.
16. The International HapMap Consortium. The International HapMap Project. Nature 2003;426:789-796.
17. Batrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinfotmatics 2005;21:263-265.
18. Li Y, Nowotny P, Holmans P, et al. Association of late-onset Alzheimet's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci USA 2004;101:15688-15693.
19. Ke, Xiayi, Hunt S, Tapper W, et al. The impact of SNP density on fine-scale patterns of linkage disequilibrium. Hum Mol Genet 2004;13:577-588.
20. Purcell S, Cherny SS, Sham PC. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003;19:149-150.
21. Cardon LR, Bell JI. Association study designs for complex diseased. Nat Rev Genet 2001;2:91-99.
22. Thomas DC, Witte JS. Point: Population stratification: a problem for case-control studies of candidate-gene associations. Caner Epidemiol Biomarkers Prev 2002;11:505-512.