Acyl-coenzyme a formation of simvastatin in mouse liver preparations

Drug Metabolism and Disposition

Volumn 34, Issue 1, 2006, Pages 102-110

  Li, Chunze ^a   Subramanian, Raju ^a,b   Yu, Sean ^a   Prueksaritanont, Thomayant ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A; DRUG METABOLITE; HYDROXYACID; LACTONE; LONG CHAIN FATTY ACID COENZYME A LIGASE; OCTANOYL S ACYL COENZYME A; PALMITOYL S ACYL COENZYME A; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL FRACTIONATION; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHROMATOGRAPHY; DIASTEREOISOMER; DRUG METABOLISM; FATTY ACID OXIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDRATION; IN VITRO STUDY; ISOMER; LACTONIZATION; LIVER; LIVER CYTOSOL; LIVER METABOLISM; MALE; MASS SPECTROMETRY; MICROSOME; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STEREOSPECIFICITY; TISSUE PREPARATION; ULTRAVIOLET SPECTROSCOPY;

ACETYL-COA C-ACYLTRANSFERASE; ACYL COENZYME A; ADENOSINE TRIPHOSPHATE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ISOMERISM; MAGNETIC RESONANCE IMAGING; MICE; MICROSOMES, LIVER; OXIDATION-REDUCTION; SIMVASTATIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFIDES;

ANIMALIA;

EID: 29944433336     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.006650     Document Type: Article

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