Insecticidal arylalkylbenzhydrolpiperidines: Novel inhibitors of voltage-sensitive sodium and calcium channels in mammalian brain

Pest Management Science

Volumn 57, Issue 10, 2001, Pages 889-895

  Leong, Darrell ^a,b,c   Bloomquist, Jeffrey R ^a,b,c   Bempong, Jeffrey ^a,b   Dybas, Jane A ^a,b   Kinne, Lyle P ^a,b   Lyga, John W ^a   Marek, Francis L ^a   Nicholson, Russell A ^a,b,c  

^a SIMON FRASER UNIVERSITY   (Canada)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c FMC CORPORATION   (United States)

Author keywords

Calcium channels; Insecticidal arylalkylbenzhydrolpiperidines (BZPs); Mode of action; Mouse brain; Sodium channels; Synaptoneurosomes; Synaptosomes

Indexed keywords

4 CARBOMETHOXYAMINOBENZYLPIPERIDINE DERIVATIVE; BATRACHOTOXIN; BATRACHOTOXININ A 20ALPHA BENZOATE; BENZHYDROLPIPERIDINE DERIVATIVE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; INSECTICIDE; PIPERIDINE DERIVATIVE; SODIUM; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

INSECTICIDE; PHYSIOLOGICAL RESPONSE;

ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BINDING AFFINITY; BINDING SITE; BRAIN; BRAIN NERVE CELL; CALCIUM CHANNEL; CALCIUM TRANSPORT; CELL MEMBRANE POTENTIAL; CHEMISTRY; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; IC 50; LEPIDOPTERA; LIGAND BINDING; MALE; METABOLISM; MOUSE; NERVE CELL; NONHUMAN; PATCH CLAMP; SODIUM CHANNEL; SYNAPTOSOME; TOXICITY TESTING;

ANIMALS; BATRACHOTOXINS; BRAIN; CALCIUM; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; INSECTICIDES; LEPIDOPTERA; MALE; MEMBRANE POTENTIALS; MICE; NEURONS; PATCH-CLAMP TECHNIQUES; PIPERIDINES; SODIUM; SODIUM CHANNELS; SYNAPTOSOMES; TOXICITY TESTS;

MAMMALIA; RODENTIA;

EID: 0034759406     PISSN: 1526498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ps.352     Document Type: Conference Paper

References (30)

1. Arylalkylbenzhydrolpiperidines: Discovery and structure-activity relationships of a new class of lepidoptericides, Paper No 10
2. Mode of action of insecticidal dihydropyrazoles: Selective block of impulse generation in sensory nerves
3. Slow voltage-dependent block of sodium channels in crayfish nerve by dihydropyrazole insecticides
4. RH 3421, an insecticidal dihydropyrazole, inhibits sodium channel-dependent sodium uptake into mouse brain preparations
5. 2+ uptake in mammalian synaptosomes
6. The novel neuroprotective agent, RS-87476, potently inhibits sodium currents in mouse neuroblastoma
7. 2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones
8. Sodium channel pharmacology in mammalian cardiac cells: Extension by DPI 201-106
9. Inhibition of the myocardial calcium current by the enantiomers of DPI 201-106 and BDF 8784
10. Very high affinity interaction of DPI 201-106 and BDF 8784 enantiomers with the phenylalkylamine-sensitive calcium channel in Drosophila head membranes
11. 1-Methyl-4-phenylpyridinium-like neurotoxicity of a pyridinium metabolite derived from haloperidol: Cell culture and neurotransmitter uptake studies
12. Pyrethroids and DDT modify alkaloid-dependent sodium channel activation and its enhancement by sea anenome toxin
13. 36chloride efflux in rat cerebral cortical synaptoneurosomes
14. Fluorescence changes with rhodamine 6G associated with changes in membrane potential in synaptosomes
15. 2-(5)
16. 3H]batrachotoxinin-20-α-benzoate binding to mouse brain sodium channels by the dihydropyrazole insecticide RH 3421
17. 3H]batrachotoxinin A 20-α-benzoate to sodium channels by local anesthetics
18. Methods in binding studies
19. A rapid method for the isolation of synaptosomes on Percoll gradients
20. Measurement of intracellular free calcium using the fluorescent indicator quin-2
21. + channels in vitro: A putative endogenous ligand for depressant drug sites in CNS
22. Intracellular microelectrude recordings of resting and action potentials from the insect axon and the effects of DDT on the action potential. Studies on the mechanism of action of insecticides (XIV)
23. Modification of single sodium channels by the insecticide tetramethrin
24. The interaction of sodium channel-directed neurotoxicants and a novel insecticidal isobutylamide with central nerve terminals prepared from the cockroach (Periplaneta americana)
25. 3H]batrachotoxinin A-20-α-benzoate binding by an N-alkylamide neurotoxin
26. A novel oxadiazine insecticide is bioactivated in lepidopteran larvae
27. 3H]batrachotoxinin binding to rat cardiac sodium channels
28. 3H]-lifarizine, a high affinity probe for inactivated sodium channels
29. Flunarizine inhibits both calcium-dependent and -independent release of glutamate from synaptosomes and cultured neurones