메뉴 건너뛰기




Volumn 32, Issue 1, 2006, Pages 149-155

The effect of N-acetylcysteine on posttraumatic changes after controlled cortical impact in rats

Author keywords

Brain edema; Brain injury; Cerebral perfusion; Controlled cortical impact injury; Free radicals; N Acetylcysteine

Indexed keywords

ACETYLCYSTEINE;

EID: 29844450243     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-005-2845-4     Document Type: Article
Times cited : (34)

References (39)
  • 2
    • 4644223212 scopus 로고    scopus 로고
    • Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury
    • Clausen, F, Lundqvist, H, Ekmark, S, Lewen, A, Ebendal, T, Hillered, L (2004) Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury. J Neurotrauma 21:1168-1182
    • (2004) J Neurotrauma , vol.21 , pp. 1168-1182
    • Clausen, F.1    Lundqvist, H.2    Ekmark, S.3    Lewen, A.4    Ebendal, T.5    Hillered, L.6
  • 3
    • 0036262303 scopus 로고    scopus 로고
    • Antioxidant therapy in acute central nervous system injury: Current state
    • Gilgun-Sherki, Y, Rosenbaum, Z, Melamed, E, Offen, D (2002) Antioxidant therapy in acute central nervous system injury: current state. Pharmacol Rev 54:271-284
    • (2002) Pharmacol Rev , vol.54 , pp. 271-284
    • Gilgun-Sherki, Y.1    Rosenbaum, Z.2    Melamed, E.3    Offen, D.4
  • 4
    • 0029433307 scopus 로고
    • Inhibition of lipid peroxidation in central nervous system trauma and ischemia
    • Hall ED (1995) Inhibition of lipid peroxidation in central nervous system trauma and ischemia. J Neurol Sci 134Suppl:79-83
    • (1995) J Neurol Sci , vol.134 , Issue.SUPPL. , pp. 79-83
    • Hall, E.D.1
  • 5
    • 0027968141 scopus 로고
    • Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat
    • Smith SL, Andrus PK, Zhang JR, Hall ED (1994) Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J Neurotrauma 11:393-404
    • (1994) J Neurotrauma , vol.11 , pp. 393-404
    • Smith, S.L.1    Andrus, P.K.2    Zhang, J.R.3    Hall, E.D.4
  • 6
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • Aruoma OI, Halliwell B, Hoey BM, Butler J (1989) The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 6:593-597
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 8
    • 1642462339 scopus 로고    scopus 로고
    • Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury
    • Hart AM, Terenghi G, Kellerth JO, Wiberg M (2004) Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury. Neuroscience 125:91-101
    • (2004) Neuroscience , vol.125 , pp. 91-101
    • Hart, A.M.1    Terenghi, G.2    Kellerth, J.O.3    Wiberg, M.4
  • 9
    • 2342562573 scopus 로고    scopus 로고
    • Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke
    • Khan M, Sekhon B, Jatana M, Giri S, Gilg AG, Sekhon C, Singh I, Singh AK (2004) Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res 76:519-527
    • (2004) J Neurosci Res , vol.76 , pp. 519-527
    • Khan, M.1    Sekhon, B.2    Jatana, M.3    Giri, S.4    Gilg, A.G.5    Sekhon, C.6    Singh, I.7    Singh, A.K.8
  • 10
    • 0028870991 scopus 로고
    • N-Acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats
    • Knuckey NW, Palm D, Primiano M, Epstein MH, Johanson CE (1995) N-Acetylcysteine enhances hippocampal neuronal survival after transient forebrain ischemia in rats. Stroke 26:305-310
    • (1995) Stroke , vol.26 , pp. 305-310
    • Knuckey, N.W.1    Palm, D.2    Primiano, M.3    Epstein, M.H.4    Johanson, C.E.5
  • 11
    • 0037414415 scopus 로고    scopus 로고
    • N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia
    • Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I, Singh AK (2003) N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia. Brain Res 971:1-8
    • (2003) Brain Res , vol.971 , pp. 1-8
    • Sekhon, B.1    Sekhon, C.2    Khan, M.3    Patel, S.J.4    Singh, I.5    Singh, A.K.6
  • 12
    • 0031665112 scopus 로고    scopus 로고
    • Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent
    • Wagner R, Heckman HM, Myers RR (1998) Wallerian degeneration and hyperalgesia after peripheral nerve injury are glutathione-dependent. Pain 77:173-179
    • (1998) Pain , vol.77 , pp. 173-179
    • Wagner, R.1    Heckman, H.M.2    Myers, R.R.3
  • 13
    • 12944322204 scopus 로고    scopus 로고
    • N-Acetylcysteine attenuates early induction of heme oxygenase-1 following traumatic brain injury
    • Yi JH, Hazell AS (2005) N-Acetylcysteine attenuates early induction of heme oxygenase-1 following traumatic brain injury. Brain Res 1033:13-19
    • (2005) Brain Res , vol.1033 , pp. 13-19
    • Yi, J.H.1    Hazell, A.S.2
  • 14
    • 0027400110 scopus 로고
    • Brain hydroxyl radical generation in acute experimental head injury
    • Hall ED, Andrus PK, Yonkers PA (1993) Brain hydroxyl radical generation in acute experimental head injury. J Neurochem 60:588-594
    • (1993) J Neurochem , vol.60 , pp. 588-594
    • Hall, E.D.1    Andrus, P.K.2    Yonkers, P.A.3
  • 15
    • 0041854534 scopus 로고    scopus 로고
    • Caffeine impairs short-term neurological outcome after concussive head injury in rats
    • Al Moutaery K, Al Deeb S, Ahmad Khan H, Tariq M (2003) Caffeine impairs short-term neurological outcome after concussive head injury in rats. Neurosurgery 53:704-711
    • (2003) Neurosurgery , vol.53 , pp. 704-711
    • Al Moutaery, K.1    Al Deeb, S.2    Ahmad Khan, H.3    Tariq, M.4
  • 16
    • 0032736595 scopus 로고    scopus 로고
    • Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury
    • Sullivan PG, Thompson MB, Scheff SW (1999) Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury. Exp Neurol 160:226-234
    • (1999) Exp Neurol , vol.160 , pp. 226-234
    • Sullivan, P.G.1    Thompson, M.B.2    Scheff, S.W.3
  • 17
    • 0033178340 scopus 로고    scopus 로고
    • Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury
    • Sullivan PG, Bruce-Keller AJ, Rabchevsky AG, Christakos S, Clair DK, Mattson MP, Scheff SW (1999) Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury. J Neurosci 19:6248-6456
    • (1999) J Neurosci , vol.19 , pp. 6248-6456
    • Sullivan, P.G.1    Bruce-Keller, A.J.2    Rabchevsky, A.G.3    Christakos, S.4    Clair, D.K.5    Mattson, M.P.6    Scheff, S.W.7
  • 18
    • 0037012770 scopus 로고    scopus 로고
    • Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat
    • Aoyama N, Katayama Y, Kawamata T, Maeda T, Mori T, Yamamoto T, Kikuchi T, Uwahodo Y (2002) Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat. Brain Res 934:117-124
    • (2002) Brain Res , vol.934 , pp. 117-124
    • Aoyama, N.1    Katayama, Y.2    Kawamata, T.3    Maeda, T.4    Mori, T.5    Yamamoto, T.6    Kikuchi, T.7    Uwahodo, Y.8
  • 19
    • 0037263592 scopus 로고    scopus 로고
    • L-Arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in Rats
    • Cherian L, Robertson CS (2003) L-Arginine and free radical scavengers increase cerebral blood flow and brain tissue nitric oxide concentrations after controlled cortical impact injury in Rats. J Neurotrauma 20:77-85
    • (2003) J Neurotrauma , vol.20 , pp. 77-85
    • Cherian, L.1    Robertson, C.S.2
  • 21
    • 0037350817 scopus 로고    scopus 로고
    • Effects of lecithinized superoxide dismutase on neuronal cell loss in CA3 hippocampus after traumatic brain injury in rats
    • Yunoki M, Kawauchi M, Ukita N, Sugiura T, Ohmoto T (2003) Effects of lecithinized superoxide dismutase on neuronal cell loss in CA3 hippocampus after traumatic brain injury in rats. Surg Neurol 59:156-160
    • (2003) Surg Neurol , vol.59 , pp. 156-160
    • Yunoki, M.1    Kawauchi, M.2    Ukita, N.3    Sugiura, T.4    Ohmoto, T.5
  • 23
    • 0033673207 scopus 로고    scopus 로고
    • Riluzole reduces brain swelling and contusion volume in rats following controlled cortical impact injury
    • Stover JF, Beyer TF, Unterberg AW (2000) Riluzole reduces brain swelling and contusion volume in rats following controlled cortical impact injury. J Neurotrauma 17:1171-1178
    • (2000) J Neurotrauma , vol.17 , pp. 1171-1178
    • Stover, J.F.1    Beyer, T.F.2    Unterberg, A.W.3
  • 24
    • 0038745750 scopus 로고    scopus 로고
    • Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats
    • Stover JF, Sakowitz OW, Beyer TF, Dohse NK, Kroppenstedt SN, Thomale UW, Schaser KD, Unterberg AW (2003) Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats. J Neurotrauma 20:315-326
    • (2003) J Neurotrauma , vol.20 , pp. 315-326
    • Stover, J.F.1    Sakowitz, O.W.2    Beyer, T.F.3    Dohse, N.K.4    Kroppenstedt, S.N.5    Thomale, U.W.6    Schaser, K.D.7    Unterberg, A.W.8
  • 26
    • 0032717916 scopus 로고    scopus 로고
    • Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats
    • Xiong Y, Peterson PL, Lee CP (1999) Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. J Neurotrauma 16:1067-1082
    • (1999) J Neurotrauma , vol.16 , pp. 1067-1082
    • Xiong, Y.1    Peterson, P.L.2    Lee, C.P.3
  • 27
    • 0034578321 scopus 로고    scopus 로고
    • Bradykinin 2 receptor antagonist LF 16-0687Ms reduces posttraumatic brain edema
    • Stover JF, Dohse NK, Unterberg AW (2000) Bradykinin 2 receptor antagonist LF 16-0687Ms reduces posttraumatic brain edema. Acta Neurochir Suppl 76:171-175
    • (2000) Acta Neurochir Suppl , vol.76 , pp. 171-175
    • Stover, J.F.1    Dohse, N.K.2    Unterberg, A.W.3
  • 29
    • 0026432652 scopus 로고
    • Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure
    • Harrison PM, Wenden JA, Gimson AE, Alexander GJ, Williams R (1991) Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 324:1852-1857
    • (1991) N Engl J Med , vol.324 , pp. 1852-1857
    • Harrison, P.M.1    Wenden, J.A.2    Gimson, A.E.3    Alexander, G.J.4    Williams, R.5
  • 30
    • 0028291629 scopus 로고
    • Cerebral blood flow and metabolism in fulminant liver failure
    • Wendon JA, Harrison PM, Keays R, Williams R (1994) Cerebral blood flow and metabolism in fulminant liver failure. Hepatology 19:1407-1413
    • (1994) Hepatology , vol.19 , pp. 1407-1413
    • Wendon, J.A.1    Harrison, P.M.2    Keays, R.3    Williams, R.4
  • 31
    • 0029007827 scopus 로고
    • Superoxide dismutase improves posttraumatic cortical blood flow in rats
    • Muir JK, Tynan M, Caldwell R, Ellis EF (1995) Superoxide dismutase improves posttraumatic cortical blood flow in rats. J Neurotrauma 12:179-188
    • (1995) J Neurotrauma , vol.12 , pp. 179-188
    • Muir, J.K.1    Tynan, M.2    Caldwell, R.3    Ellis, E.F.4
  • 32
    • 11044222471 scopus 로고    scopus 로고
    • Acute effects of N-acetylcysteine on skeletal muscle microcirculation following closed soft tissue trauma in rats
    • Schaser KD, Bail HJ, Schewior L, Stover JF, Melcher I, Haas NP, Mittlmeier T (2005) Acute effects of N-acetylcysteine on skeletal muscle microcirculation following closed soft tissue trauma in rats. J Orthop Res 23:231-241
    • (2005) J Orthop Res , vol.23 , pp. 231-241
    • Schaser, K.D.1    Bail, H.J.2    Schewior, L.3    Stover, J.F.4    Melcher, I.5    Haas, N.P.6    Mittlmeier, T.7
  • 35
    • 0037342554 scopus 로고    scopus 로고
    • The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
    • Farr SA, Poon HF, Dogrukol-Ak D, Drake J, Banks WA, Eyerman E, Butterfield DA, Morley JE (2003) The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem 84:1173-1183
    • (2003) J Neurochem , vol.84 , pp. 1173-1183
    • Farr, S.A.1    Poon, H.F.2    Dogrukol-Ak, D.3    Drake, J.4    Banks, W.A.5    Eyerman, E.6    Butterfield, D.A.7    Morley, J.E.8
  • 36
    • 0343247794 scopus 로고    scopus 로고
    • The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats
    • Baskaya MK, Rao AM, Dogan A, Donaldson D, Dempsey RJ (1997) The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci Lett 226:33-36
    • (1997) Neurosci Lett , vol.226 , pp. 33-36
    • Baskaya, M.K.1    Rao, A.M.2    Dogan, A.3    Donaldson, D.4    Dempsey, R.J.5
  • 37
    • 0033046386 scopus 로고    scopus 로고
    • Lack of a neuroprotective effect from N-acetylcysteine after cardiac arrest and resuscitation in a canine model
    • Silbergleit R, Haywood Y, Fiskum G, Rosenthal RE (1999) Lack of a neuroprotective effect from N-acetylcysteine after cardiac arrest and resuscitation in a canine model. Resuscitation 40:181-186
    • (1999) Resuscitation , vol.40 , pp. 181-186
    • Silbergleit, R.1    Haywood, Y.2    Fiskum, G.3    Rosenthal, R.E.4
  • 38
    • 0025988594 scopus 로고
    • Restoration of cerebrovascular responsiveness to hyperventilation by the oxygen radical scavenger N-acetylcysteine following experimental traumatic brain injury
    • Ellis EF, Dodson LY, Police RJ (1991) Restoration of cerebrovascular responsiveness to hyperventilation by the oxygen radical scavenger N-acetylcysteine following experimental traumatic brain injury. J Neurosurg 75:774-749
    • (1991) J Neurosurg , vol.75 , pp. 774-1749
    • Ellis, E.F.1    Dodson, L.Y.2    Police, R.J.3
  • 39
    • 0035153052 scopus 로고    scopus 로고
    • Expression of nuclear factor kappaB and tumor necrosis factor alpha in the mouse brain after experimental thermal ablation injury
    • Nomoto Y, Yamamoto M, Fukushima T, Kimura H, Ohshima K, Tomonaga M (2001) Expression of nuclear factor kappaB and tumor necrosis factor alpha in the mouse brain after experimental thermal ablation injury. Neurosurgery 48:158-166
    • (2001) Neurosurgery , vol.48 , pp. 158-166
    • Nomoto, Y.1    Yamamoto, M.2    Fukushima, T.3    Kimura, H.4    Ohshima, K.5    Tomonaga, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.