N-acetylcysteine attenuates early induction of heme oxygenase-1 following traumatic brain injury

Brain Research

Volumn 1033, Issue 1, 2005, Pages 13-19

  Yi, Jae Hyuk ^a   Hazell, Alan S ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Antioxidant; Astrocyte; Fluid percussion; Heme oxygenase; Oxidative stress; Traumatic brain injury

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; HEME OXYGENASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN INJURY; CONTROLLED STUDY; ENZYME INDUCTION; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; THALAMUS;

ACETYLCYSTEINE; ANIMALS; BLOTTING, WESTERN; BRAIN INJURIES; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; HEAT-SHOCK PROTEINS; HEME OXYGENASE (DECYCLIZING); IMMUNOHISTOCHEMISTRY; MALE; OXYGENASES; PERCUSSION; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS, NONPARAMETRIC; TETRAZOLIUM SALTS; TIME FACTORS;

EID: 12944322204     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.10.055     Document Type: Article

References (28)

1. N.G. Abraham, Y. Lavrovsky, M.L. Schwartzman, R.A. Stoltz, R.D. Levere, M.E. Gerritsen, S. Shibahara, and A. Kappas Transfection of the human heme oxygenase gene into rabbit coronary microvessel endothelial cells: protective effect against heme and hemoglobin toxicity Proc. Natl. Acad. Sci. U. S. A. 92 1995 6798 6802
2. M.K. Baskaya, A. Docan, C. Temiz, and R.J. Dempsey Application of 2,3,5-triphenyltetrazolium chloride staining to evaluate injury volume after controlled cortical impact brain injury: role of brain edema in evolution of injury volume J. Neurotrauma 17 2000 93 99
3. M. Bergeron, D.M. Ferriero, H.J. Vreman, D.K. Stevenson, and F.R. Sharp Hypoxia-ischemia, but not hypoxia alone, induces the expression of heme oxygenase-1 (HSP32) in newborn rat brain J. Cereb. Blood Flow Metab. 17 1997 647 658
4. R. Beschorner, D. Adjodah, J.M. Schwab, M. Mittelbronn, I. Pedal, R. Mattern, H.J. Schluesener, and R. Meyermann Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans Acta Neuropathol. (Berl) 100 2000 377 384
5. E.F. Ellis, L.Y. Dodson, and R.J. Police Restoration of cerebrovascular responsiveness to hyperventilation by the oxygen radical scavenger n-acetylcysteine following experimental traumatic brain injury J. Neurosurg. 75 1991 774 779
6. K. Fukuda, J.D. Richmon, M. Sato, F.R. Sharp, S.S. Panter, and L.J. Noble Induction of heme oxygenase-1 (HO-1) in glia after traumatic brain injury Brain Res. 736 1996 68 75
7. P. Garnier, C. Demougeot, N. Bertrand, A. Prigent-Tessier, C. Marie, and A. Beley Stress response to hypoxia in gerbil brain: HO-1 and Mn SOD expression and glial activation Brain Res. 893 2001 301 309
8. A.S. Hazell, K.V. Rao, N.C. Danbolt, D.V. Pow, and R.F. Butterworth Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy J. Neurochem. 78 2001 560 568
9. B.H. Juurlink, and P.G. Paterson Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies J. Spinal Cord Med. 21 1998 309 334
10. G.S. Kelly Clinical applications of N-acetylcysteine Altern. Med. Rev. 3 1998 114 127
11. M. Kweon, M. Jung, and H. Sung Cytoprotective effects of heme oxygenase-1 induction by 3-O-caffeoyl-1-methylquinic acid Free Radic. Biol. Med. 36 2004 40 52
12. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the folin phenol reagent J. Biol. Chem. 193 1951 263 275
13. T.K. McIntosh, R. Vink, L. Noble, I. Yamakami, S. Fernyak, H. Soares, and A.L. Faden Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model Neuroscience 28 1989 233 244
14. K.A. Nath, G. Balla, G.M. Vercellotti, J. Balla, H.S. Jacob, M.D. Levitt, and M.E. Rosenberg Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat J. Clin. Invest. 90 1992 267 270
15. L. Otterbein, S.L. Sylvester, and A.M. Choi Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1 Am. J. Respir. Cell Mol. Biol. 13 1995 595 601
16. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 1998 Academic Press San Diego
17. B.R. Perri, D.H. Smith, H. Murai, G. Sinson, K.E. Saatman, R. Ragupathi, R.T. Bartus, and T.K. McIntosh Metabolic quantification of lesion volume following experimental traumatic brain injury in the rat J. Neurotrauma 14 1997 15 22
18. R.R. Ratan, T.H. Murphy, and J.M. Baraban Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione J. Neurosci. 14 1994 4385 4392
19. R.F. Regan, and B. Rogers Delayed treatment of hemoglobin neurotoxicity J. Neurotrauma 20 2003 111 120
20. G. Scapagnini, V. D'Agata, V. Calabrese, A. Pascale, C. Colombrita, D. Alkon, and S. Cavallaro Gene expression profiles of heme oxygenase isoforms in the rat brain Brain Res. 954 2002 51 59
21. B. Sekhon, C. Sekhon, M. Khan, S.J. Patel, I. Singh, and A.K. Singh N-acetyl cysteine protects against injury in a rat model of focal cerebral ischemia Brain Res. 971 2003 1 8
22. Y. Shan, R.W. Lambrecht, T. Ghaziani, S.E. Donohue, and H.L. Bonkovsky Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAs J. Biol. Chem. 2004 (in press)
23. C.P. Turner, M. Bergeron, P. Matz, A. Zegna, L.J. Noble, S.S. Panter, and F.R. Sharp Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin J. Cereb. Blood Flow Metab. 18 1998 257 273
24. C.P. Turner, S.S. Panter, and F.R. Sharp Anti-oxidants prevent focal rat brain injury as assessed by induction of heat shock proteins (HSP70, HO-1/HSP32, HSP47) following subarachnoid injections of lysed blood Mol. Brain Res. 65 1999 87 102
25. G.F. Vile, S. Basu-Modak, C. Waltner, and R.M. Tyrrell Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts Proc. Natl. Acad. Sci. U. S. A. 91 1994 2607 2610
26. S.R. Vincent, S. Das, and M.D. Maines Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons Neuroscience 63 1994 223 231
27. K.R. Wagner, F.R. Sharp, T.D. Ardizzone, A. Lu, and J.F. Clark Heme and iron metabolism: role in cerebral hemorrhage J. Cereb. Blood Flow Metab. 23 2003 629 652
28. Y. Xiong, P.L. Peterson, and C.P. Lee Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats J. Neurotrauma 16 1999 1067 1082