Effects of antioxidant, OPC-14117, on secondary cellular damage and behavioral deficits following cortical contusion in the rat

Brain Research

Volumn 934, Issue 2, 2002, Pages 117-124

  Aoyama, Naoki ^a,c   Katayama, Yoichi ^a   Kawamata, Tatsuro ^a   Maeda, Takeshi ^a   Mori, Tatsuro ^a   Yamamoto, Takamitsu ^a   Kikuchi, Tetsuro ^b   Uwahodo, Yasuhumi ^b  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c NONE   (Japan)

Author keywords

Cerebral contusion; Cognitive behavior; Edema formation; Free radical scavenger; Rat; Tissue osmolality

Indexed keywords

ANTIOXIDANT; N (7 HYDROXY 2,2,4,6 TETRAMETHYL 1 INDANYL) 4 (3 METHOXYPHENYL) 1 PIPERAZINEACETAMIDE; SCAVENGER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATTENUATION; BEHAVIOR DISORDER; BRAIN CONTUSION; BRAIN CORTEX; BRAIN INJURY; BRAIN NERVE CELL; BRAIN TISSUE; CELL COUNT; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFECT; EXPLORATORY BEHAVIOR; HABITUATION; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MAZE TEST; MENTAL PERFORMANCE; NERVE CELL NECROSIS; NONHUMAN; OSMOLALITY; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

ANIMALS; ANTIOXIDANTS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; BRAIN EDEMA; BRAIN INJURIES; CELL DEATH; CEREBRAL CORTEX; COGNITION DISORDERS; HIPPOCAMPUS; INDANS; MALE; MAZE LEARNING; NECROSIS; NERVE DEGENERATION; OSMOLAR CONCENTRATION; OXIDATIVE STRESS; PIPERAZINES; RATS; RATS, WISTAR; SPECIFIC GRAVITY; TIME FACTORS;

EID: 0037012770     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02366-1     Document Type: Article

References (45)

1. Regional cerebral blood flow trends in head injured patients with focal contusions and cerebral edema
2. Neuronal cell loss in the CA3 subfield of the hippocampus following cortical contusion utilizing the optical dissector method for cell counting
3. The time course of vasogenic oedema after focal human head injury: Evidence from SPECT mapping of blood brain barrier defects
4. Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact in rats
5. Excitotoxic cell death
6. A controlled cortical impact model of traumatic brain injury in the rat
7. The role of excitatory amino acids and NMDA receptors in traumatic brain injury
8. Inhibition of stimulated leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117
9. Free radicals in cerebral ischemia
10. Glutamate release and free radical production following brain injury: Effects of posttraumatic hypothermia
11. Lateral cortical impact injury in rats: Pathologic effects of varying cortical compression and impact velocity
12. Brain hydroxyl radical generation in acute experimental head injury
13. Ischemic brain edema and the osmotic gradient between blood and brain
14. Microvascular alterations following cerebral contusion in rats
15. Mild experimental brain injury in rat induces cognitive deficits associated with regional neuronal loss in the hippocampus
16. Osmolality of brain in cerebral ischemia
17. Central nervous system trauma: Secondary injury and acidosis
18. Oxygen free radicals and brain dysfunction
19. Massive increase in extracellular potassium and indiscriminative glutamate release after concussive brain injury
20. Intraparenchymal fluid-blood levels in traumatic intracerebral hematomas
21. Role of excitatory amino acid-mediated ionic fluxes in traumatic brain injury
22. Involvement of multiple subreceptors of excitatory amino acids in trauma-induced selective death of hippocampal CA3 neurons
23. Pathogenesis of the mass effect of cerebral contusions: Rapid increase in osmolality within the contusion necrosis
24. Measurement of excitatory amino acid release in glioma and contused brain tissue during intracranial surgery
25. Lipid peroxidation in focal cerebral ischemia
26. Oxygen radicals in brain injury
27. Superoxide production in experimental brain injury
28. Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat
29. A simple gravimetric technique for measurement of cerebral edema
30. Selective vulnerability of hippocampal CA3 region in controlled cortical contusion model in a rat
31. Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: Role of platelet activating factor
32. Synaptic plasticity and learning: Selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5
33. Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells
34. Oxygen radicals in cerebral ischemia
35. Rat brain osmolality during barbiturate anesthesia and global brain ischemia
36. Novel cerebroprotective agents with central nervous system stimulating activity. 2. Synthesis and pharmacology of 1-(acylamino)-7-hydroxyindan derivatives
37. Habituation of exploratory activity in mice: A screening test for memory enhancing drugs
38. Evidence of apoptotic cell death after experimental traumatic brain injury in the rat
39. Evaluation of memory dysfunction following experimental brain injury using the Morris water maze
40. A model of parasagittal controlled cortical impact in the mouse: Cognitive and histopathologic effects
41. Direct measurement of hydroxyl radicals, lipid peroxidation and blood-brain barrier disruption following unilateral cortical impact head injury in the rat
42. Fetal hippocampal transplants attenuate CA3 pyramidal cell death resulting from fluid percussion brain injury in the rat
43. Intracerebral administration of alpha-tocopherol containing liposomes facilitates behavioral recovery in rats with bilateral lesions of the frontal cortex
44. Protective effects of OPC-14117 on dopaminergic neuronal degeneration induced by MPTP in ICR mice
45. Neuronal protection with superoxide dismutase in repetitive forebrain ischemia in gerbils