Cocaine increases intracellular calcium and reactive oxygen species, depolarizes mitochondria, and activates genes associated with heart failure and remodeling

Cardiovascular Toxicology

Volumn 5, Issue 4, 2005, Pages 377-389

  Lattanzio Jr , Frank A ^a   Tiangco, David ^b   Osgood, Christopher ^b   Beebe, Stephen ^a   Kerry, Julie ^a   Hargrave, Barbara Y ^b  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b OLD DOMINION UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ANGIOTENSINOGEN; BETA 1 ADRENERGIC RECEPTOR; C REACTIVE PROTEIN; CALCIUM; COCAINE; CYTOKINE RECEPTOR LIKE FACTOR 1; DICHLORODIHYDROFLUORESCEIN DIACETATE; FAS ANTIGEN; FAS LIGAND; GLUTATHIONE; NADOLOL; NIFEDIPINE; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LINE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA MICROARRAY; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; HEART ARRHYTHMIA; HEART DISEASE; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MITOCHONDRION; HEART VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; MEMBRANE DEPOLARIZATION; MICROARRAY ANALYSIS; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT;

ACETYLCYSTEINE; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; COCAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; GLUTATHIONE; HEART FAILURE, CONGESTIVE; INTRACELLULAR MEMBRANES; MEMBRANE POTENTIALS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MYOCYTES, CARDIAC; NARCOTICS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RABBITS; REACTIVE OXYGEN SPECIES; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 29644441890     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1385/CT:5:4:377     Document Type: Article

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