Time course of dopamine D2 receptor occupancy by clozapine with medium and high plasma concentrations

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 30, Issue 1, 2006, Pages 75-81

  Takano, Akihiro ^a,b   Suhara, Tetsuya ^a,b   Kusumi, Ichiro ^c   Takahashi, Yoshito ^c   Asai, Yoshiyuki ^a,c   Yasuno, Fumihiko ^a,b   Ichimiya, Tetsuya ^a,b   Inoue, Makoto ^a,b   Sudo, Yasuhiko ^a,b   Koyama, Tsukasa ^c  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Clozapine; Dopamine D2 receptor occupancy; PET; Plasma concentration; Time course

Indexed keywords

CARBON 11; CLOZAPINE; DOPAMINE 2 RECEPTOR; FLUVOXAMINE; HALOPERIDOL; ISOREMOXIPRIDE; OLANZAPINE; PAROXETINE;

ADULT; ARTICLE; CASE REPORT; CHRONIC DRUG ADMINISTRATION; CORPUS STRIATUM; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG RECEPTOR BINDING; HEMOCONCENTRATION; HUMAN; IN VIVO STUDY; MALE; MENTAL PATIENT; MONKEY; POSITRON EMISSION TOMOGRAPHY; RECEPTOR OCCUPANCY; SCHIZOPHRENIA; SIMULATION; THEORETICAL STUDY;

ADULT; ANTIPSYCHOTIC AGENTS; CARBON ISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOZAPINE; COMPUTER SIMULATION; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROCHEMISTRY; FLUVOXAMINE; HUMANS; MALE; PAROXETINE; POSITRON-EMISSION TOMOGRAPHY; PYRROLIDINES; RECEPTORS, DOPAMINE D2; SALICYLAMIDES; SCHIZOPHRENIA; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS;

EID: 29644437765     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2005.06.011     Document Type: Article

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