A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathies

Journal of Neurology

Volumn 251, Issue 10, 2004, Pages 1260-1266

  Hahn, K ^f   Arendt, G ^a   Braun, J S ^f   Von Giesen, H J ^a   Husstedt, I W ^b   Maschke, M ^c   Straube, E ^d   Schielke, E ^e  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d Neurological Clinic   (Germany)

^e Vivantes Auguste Viktoria Klinikum   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Gabapentin; HIV; Neuropathic pain; Neuropathy

Indexed keywords

GABAPENTIN;

ADULT; ARTICLE; ATAXIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DRUG EFFICACY; FEMALE; FOLLOW UP; HEADACHE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NAUSEA; NEUROPATHIC PAIN; PATHOGENESIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSORY NEUROPATHY; SOMNOLENCE; TITRIMETRY; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

ADULT; AMINES; ANALGESICS; CYCLOHEXANECARBOXYLIC ACIDS; DOUBLE-BLIND METHOD; FEMALE; GAMMA-AMINOBUTYRIC ACID; HIV SEROPOSITIVITY; HUMANS; MALE; MIDDLE AGED; NEURALGIA; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; SLEEP; TIME FACTORS; TREATMENT OUTCOME;

EID: 8744261620     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00415-004-0529-6     Document Type: Article

References (27)

1. Abdi S, Lee DH, Chung JM (1998) The anti-allodynic effects of amitryptiline, gabapentin and lidocaine in an art model of neuropathic pain. Anesth Analg 87:1360-1366
2. Backonja M, Beydoun A, Edwards KR, et al. (1998) Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 280:1831-1836
3. Childs EA, Lyles RH, Selnes OD, et al. (1999) Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy. Neurology 52:607-613
4. Deutsche Neuro-AIDS-Arbeitsgemeinschaft [DNAA] (2000) Erkrankungen des peripheren Nervensystems und der Muskulatur bei der HIV-Infektion. Nervenarzt 71(6):442-450
5. Gatti A, Jann S, Sandro B, Manuela B (1998) Gabapentin in the treatment of distal symmetric axonopathy in HIV infected patients. Neurology 50:A216 abstract (P04.053)
6. Griffin JW, Crawford TO, McArthur JC, et al. (1998) Peripheral neuropathies associated with HIV infection. In: Gendelman HE, Lipton SA, Epstein L, Swindells S (eds) The neurology of AIDS. New York, Chapman & Hall, pp 275-291
7. Husstedt IW, Grotemeyer KH, Busch J, Zidek W (1994) Early detection of distal symmetrical polyneuropathy during HIV infection by paired stimulation of sural nerve. Electroencephalogr Clin Neurophysiol 93:169-174
8. Keswani SC, Pardo C, Cherry CL, Hoke A, McArthur JC (2002) HIV-associated sensory neuropathies. AIDS 16: 2105-2117
9. Kieburtz K, Simpson D, Yiannoutsos C, et al. (1998) A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. Neurology 51:1682-1688
10. Lange D (1994) AAEM minimonograph #41: Neuromuscular diseases associated with HIV-1 infection. Muscle Nerve 17:16-30
11. La Spina I, Porazzi D, Maggiolo F, Bottura P, Suter F (2001) Gabapentin in painful HIV-related neuropathy: a report of 19 patients, preliminary observations. Eur J Neurol 8:71-75
12. Malessa R, Agelink M, Himmelmann M, Kloss T, Mertins L, Brockmeyer NH (1996) Nerve conduction changes in asymptomatic HIV-1 seropositive individuals in the absence of other risk factors for neuropathy. Electromyogr Clin Neurophysiol 36:3-8
13. McArthur JC, Yiannoutsos C, Simpson DM, et al. (2000) A phase II trial of nerve growth factor for sensory neuropathy associated with HIV-infection. Neurology 54:1080-1088
14. McQuay H, Carroll D, Moore A (1995) Variation in the placebo effect in randomised controlled trials of analgesics: all is as blind as it seems. Pain 64: 331-335
15. Newshan G (1998) HIV neuropathy treated with gabapentin. AIDS 12: 219-221
16. Novakovic SD, Tzoumaka E, McGivern JG, et al. (1998) Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J Neurosci 18:2174-2187
17. Paice JA, Estwing Ferrans C, Lashley FR, Shott S, Vizgirda V, Pitrak D (2000) Topical capsaicin in the management of HIV-associated peripheral neuropathy. J Pain Symptom Manage 19(1): 45-52
18. Pan HL, Eisenach JC, Chen SR (1999) Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther 288:1026-1030
19. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L (1998) Gabapentin for the treatment of post-herpetic neuralgia: a randomized controlled trial. JAMA 280:1837-1842
20. Schiffito G, Yiannoutsos C, Simpson DM, et al. (2001) Long-term treatment with recombinant nerve growth factor for HIV-associated sensory neuropathy. Neurology 57:1313-1316
21. Shlay JC, Chaloner K, Max MB, et al. (1998) Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy; a randomized trial. JAMA 280(18):1590-1595
22. Simpson DM, Dorfman D, Olney RK, et al. (1996) Peptide T in the treatment of painful distal neuropathy associated with AIDS: results of a placebo-controlled trial. The peptide T Neuropathy Study Group. Neurology 47:1254-1259
23. Simpson DM, Olney R, McArthur JC, Khan A, Godbold J, Ebel-Frommer K (2000) A placebo-controlled trial of lamotrigine for painful HIV-associated neuropathy. Neurology 54:2115-2119
24. Simpson DM, McArthur JC, Olney R, et al. (2003) Lamotrigine for HIV-associated painful sensory neuropathies: A placebo-controlled trial. Neurology 60:1508-1514
25. Tagliati M, Grinnel J, Godbold J, Simpson DM (1999) Peripheral nerve function in HIV infection: clinical, electrophysiologic, and laboratory findings. Arch Neurol 56:84-89
26. Taylor CP, Gee NS, Su TZ, et al. (1998) A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 29:233-249
27. Woolf CJ, Salter MW (2000) Neuronal plasticity: increasing the gain in pain. Science 288:1765-1769