Short-term effect of atorvastatin on ischaemic threshold in hypercholesterolaemic patients with stable ischaemic heart disease

Acta Cardiologica

Volumn 59, Issue 3, 2004, Pages 269-274

  Claeys, Marc J ^j   Cosyns, Bernard ^a   Hoffer, Etienne ^b   Carlier, Marc ^c   Missault, Luc ^d   Cools, Frank ^e   De Meester, Antoine ^f   Vermeersch, Paul ^g   Gobin, Eric ^h   Dewit, Brigitte ⁱ  

^a Braine L'Alleud Hospital   (Belgium)

^b Centre Hospitalier Regional de La Citadelle   (Belgium)

^c Hopital St Joseph   (Belgium)

^d Cardiology   (Belgium)

^e Cardiology   (Belgium)

^f Hospital de Jolimont   (Belgium)

^g Dienst Cardiologie   (Belgium)

^h UNIVERSITY OF LIÈGE   (Belgium)

ⁱ Europe St Michel Clinic   (Belgium)

^j ANTWERP UNIVERSITY HOSPITAL   (Belgium)

more..

Author keywords

Hypercholesterolaemia; Myocardial ischaemia; Statin

Indexed keywords

ANTILIPEMIC AGENT; ATORVASTATIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; STATINE DERIVATIVE;

ADULT; AGED; ARTICLE; ATRIOVENTRICULAR BLOCK; BACKACHE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIZZINESS; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; EXERCISE ELECTROCARDIOGRAPHY; FEMALE; FLU LIKE SYNDROME; GASTROINTESTINAL SYMPTOM; GOUT; HEART MUSCLE ISCHEMIA; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; LIPID BLOOD LEVEL; MALE; MULTICENTER STUDY; RASH; ST SEGMENT DEPRESSION; URINARY TRACT DISEASE; VASODILATATION;

AGED; ANGINA PECTORIS; CHOLESTEROL, LDL; DISEASE PROGRESSION; EXERCISE TEST; FEMALE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; MALE; MYOCARDIAL ISCHEMIA; PYRROLES; TIME FACTORS;

EID: 2942752311     PISSN: 00015385     EISSN: None     Source Type: Journal    
DOI: 10.2143/AC.59.3.2005181     Document Type: Article

References (26)

1. Adams MR, Kinlay S, Blake GJ, Orford JL, Ganz P, Selwyn AP. Atherogenic lipids and endothelial dysfunction: mechanisms in the genesis of ischemic syndromes. Annu Rev Med 2000; 51: 149-67.
2. Kaufmann P, Matter C, Mandinov L, Frielingsdorf J, Seiler C, Hess OM. High level of cholesterol increases coronary vasomotor tone during exercise. Coron Artery Dis 2000; 11(6): 459-66.
3. Sessa WC. Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins? Trends Mol Med 2001; 7(5): 189-91.
4. O'Driscoll G, Green D, Taylor RR. Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month. Circulation 1997; 95(5): 1126-31.
5. Dupuis J, Tardif JC, Cernacek P, Theroux P. Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes. The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial. Circulation 1999; 99(25): 3227-33.
6. Marchesi S, Lupattelli G, Siepi D, Schillaci G, Vaudo G, Roscini AR, Sinzinger H, Mannarino E. Short-term atorvastatin treatment improves endothelial function in hypercholesterolemic women. J Cardiovasc Pharmacol 2000; 36(5): 617-21.
7. Laufs U, Wassmann S, Hilgers S, Ribaudo N, Bohm M, Nickenig G. Rapid effects on vascular function after initiation and withdrawal of atorvastatin in healthy, normocholesterolemic men. Am J Cardiol 2001; 88(11): 1306-7.
8. Masumoto A, Hirooka Y, Hironaga K, Eshima K, Setoguchi S, Egashira K, Takeshita A. Effect of pravastatin on endothelial function in patients with coronary artery disease (cholesterol-independent effect of pravastatin). Am J Cardiol 2001; 88(11): 1291-4.
9. Tamai O, Matsuoka H, Itabe H, Wada Y, Kohno K, Imaizumi T. Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans. Circulation 1997; 95(1): 76-82.
10. Nawrocki JW, Weiss SR, Davidson MH, Sprecher DL, Schwartz SL, Lupien PJ, Jones PH, Haber HE, Black DM. Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arterioscler Thromb Vasc Biol 1995; 15(5): 678-82.
11. Schrott H, Fereshetian AG, Knopp RH, Bays H, Jones PH, Littlejohn TW, III, McLain R, Black DM. A multicenter, placebo-controlled, dose-ranging study of atorvastatin. J Cardiovasc Pharmacol Ther 1998; 3(2): 119-24.
12. Wassmann S, Laufs U, Baumer AT, Muller K, Ahlbory K, Linz W, Itter G, Rosen R, Bohm M, Nickenig G. HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species. Hypertension 2001; 37(6): 1450-7.
13. Perticone F, Ceravolo R, Maio R, Cloro C, Candigliota M, Scozzafava A, Mongiardo A, Mastroroberto P, Chello M, Mattioli PL. Effects of atorvastatin and vitamin C on endothelial function of hypercholesterolemic patients. Atherosclerosis 2000; 152(2): 511-8.
14. Ramires JA, Sposito AC, Mansur AP, Coelho OR, Maranhao M, Cesar LA. Cholesterol lowering with statins reduces exercise-induced myocardial ischemia in hypercholesterolemic patients with coronary artery disease. Am J Cardiol 2001; 88(10): 1134-8.
15. Prasad A, Mincemoyer R, Quyyumi AA. Anti-ischemic effects of angiotensin-converting enzyme inhibition in hypertension. J Am Coll Cardiol 2001; 38(4): 1116-22.
16. Cannon RO, III. Cardiovascular benefit of cholesterol-lowering therapy: does improved endothelial vasodilator function matter? Circulation 2000; 102(8): 820-2.
17. Quyyumi AA. Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? A double-blind comparison of parenteral D- and L-arginine. J Am Coll Cardiol 1998; 32(4): 904-11.
18. Egashira K, Hirooka Y, Kai H, Sugimachi M, Suzuki S, Inou T, Takeshita A. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Circulation 1994; 89(6): 2519-24.
19. Treasure CB, Klein JL, Weintraub WS, Talley JD, Stillabower ME, Kosinski AS, Zhang J, Boccuzzi SJ, Cedarholm JC, Alexander RW. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 1995; 332(8): 481-7.
20. Andrews TC, Raby K, Barry J, Naimi CL, Allred E, Ganz P, Selwyn AP. Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease. Circulation 1997; 95(2): 324-8.
21. Mansur AP, Serrano CV, Jr, Nicolau JC, Cesar LA, Ramires JA. Effect of cholesterol lowering treatment on positive exercise tests in patients with hypercholesterolaemia and normal coronary angiograms. Heart 1999; 82(6): 689-93.
22. van Boven AJ, Jukema JW, Zwinderman AH, Crijns HJ, Lie KI, Bruschke AV. Reduction of transient myocardial ischemia with pravastatin in addition to the conventional treatment in patients with angina pectoris. REGRESS Study Group. Circulation 1996; 94(7): 1503-5.
23. Pitt B, Waters D, Brown WV, van Boven AJ, Schwartz L, Title LM, Eisenberg D, Shurzinske L, McCormick LS. Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. Atorvastatin versus revascularization treatment Investigators. N Engl J Med 1999; 341(2): 70-6.
24. Vasa M, Fichtlscherer S, Adler K, Aicher A, Martin H, Zeiher AM, Dimmeler S. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation 2001; 103(24): 2885-90.
25. Dujovne CA, Harris WS, Altman R, Overhiser RW, Black DM. Effect of atorvastatin on hemorheologic-hemostatic parameters and serum fibrinogen levels in hyperlipidemic patients. Am J Cardiol 2000; 85(3): 350-3.
26. Marraccini P, Levantesi D, Michelassi C, Dalle VM, L'Abbate A. Individual variability in symptoms, ischemic threshold and cardiovascular efficiency during exercise testing in patients with effort angina. Can J Cardiol 1989; 5(4): 222-8.