Cardiovascular benefit of cholesterol-lowering therapy: Does improved endothelial vasodilator function matter?

Circulation

Volumn 102, Issue 8, 2000, Pages 820-822

  Cannon III, Richard O ^a,b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cholesterol; Editorials; Endothelium; Statins; Vasodilation

Indexed keywords

ALPHA TOCOPHEROL; ANTILIPEMIC AGENT; ANTIOXIDANT; ARGININE; ATORVASTATIN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ESTROGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; PRAVASTATIN; PROGESTERONE; SIMVASTATIN;

ATHEROSCLEROTIC PLAQUE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DISEASE COURSE; DOUBLE BLIND PROCEDURE; EDITORIAL; ESTROGEN THERAPY; HUMAN; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME; VITAMIN INTAKE;

EID: 0034702922     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.8.820     Document Type: Editorial

References (22)

1. The obligatory roll of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
2. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
3. Nitric oxide activity in the human coronary circulation: Impact of risk factors for atherosclerosis
4. Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolemic patients
5. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia
6. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease
7. The effect of cholesterol lowering and antioxidant therapy on endothelium-dependent coronary vasomotion
8. Reduction of transient myocardial ischemia with pravastatin in addition to conventional treatment in patients with angina pectoris
9. Effect of cholesterol reduction on myocardial ischemia in patients with coronary disease
10. Effect of cholesterol-lowering therapy on coronary endothelial vasomotor function in patients with coronary artery disease
11. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
12. Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease
13. Long-term anti-ischemic effects of angiotensin-converting enzyme inhibition in patients with myocardial infarction
14. Beneficial effect of oestrogen on exercise induced myocardial ischemia in women with coronary artery disease
15. Does sublingual 17β-estradiol have any effects on exercise capacity and myocardial ischemia in postmenopausal women with stable coronary artery disease?
16. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women
17. Randomized controlled trial of vitamin E in patients with coronary artery disease: Cambridge Heart Antioxidant Study
18. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial
19. Vitamin E supplementation and cardiovascular events in high-risk patients
20. Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? A double-blind comparison of parenteral D- and L-arginine
21. Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels
22. Long-term effects of pravastatin on plasma concentration of C-reactive protein