Dietary clofibrate inhibits induction of hepatic antioxidant enzymes by chronic estradiol in female ACI rats

Toxicology

Volumn 200, Issue 2-3, 2004, Pages 103-111

  Mesia Vela, Sonia ^a   Sanchez, Rosa I ^a   Reuhl, Kenneth R ^b   Conney, Allan H ^c   Kauffman, Frederick C ^a  

^a Lab for Cell and Biochem Toxicol   (United States)

^b Neurotoxicology Laboratories   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

ACI rat; Antioxidant; Antioxidant enzymes; CAT; Clofibrate; Estradiol; GPx; GST; NQO1; Peroxisome proliferators

Indexed keywords

CATALASE; CLOFIBRATE; ESTRADIOL; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BREAST TUMOR; CHRONIC DRUG ADMINISTRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIETARY INTAKE; DRUG ACTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; EVALUATION; FEMALE; LIVER MICROSOME METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; REDUCTION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTIOXIDANTS; CATALASE; CLOFIBRATE; DIET; ELECTRON TRANSPORT COMPLEX I; ENZYME INHIBITORS; ESTRADIOL; FEMALE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIVER; RATS; RATS, INBRED STRAINS;

ANIMALIA; FELIS CATUS;

EID: 2942729478     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.03.009     Document Type: Article

References (39)

1. Aebi H. Catalase in vitro. Methods Enzymol. 105:1984;121-126
2. Ansell, P.J., Espinosa-Nicholas, C., Curran, E.M., Judy, B.M., Phillips, B.J., Hanniink, M., Libahn, D.B., 2004. Endocrinology 145 (1) 311-317.
3. Ashby J., Lefevre P.A., Odum J., Tinwell H., Kennedy S.J., Beresford N., Sumpter J.P. Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for a list of endocrine-disrupting agents. Regul. Toxicol. Pharmacol. 26(Pt 1):1997;96-101
4. Bremer J. The biochemistry of hypo- and hyperlipidemic fatty acid derivatives: metabolism and metabolic effects. Prog. Lipid. Res. 40(4):2001;231-268
5. Chen C., Hennig G.E., Whiteley H.E., Manautoum J.E. Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: Role of catalase induction. J. Biochem. Mol. Toxicol. 16(5):2002;227-234
6. Dhaunsi G.S., Singh I., Orak J.K., Sing A.K. Antioxidant enzymes in ciprofibrate-induced oxidative stress. Carcinogenesis. 15(9):1994;1923-1930
7. Einarsson K., Gustafsson J.A., Hellstrom K. Effects of clofibrate on the metabolism of progesterone and oestradiol in rat liver microsomal fraction. Biochem. J. 136(3):1973;623-638
8. Flohe L., Gunzler W.A. Assay of glutathione peroxidase. Meth. Enzymol. 105:1984;114-121
9. Foliot A., Touchard D., Mallet L. Inhibition of liver glutathione S-transferase activity in rats by hypolipidemic drugs related or unrelated to clofibrate. Biochem. Pharmacol. 35:1986;1685-1690
10. Fujita T., Kobayashi Y., Wada O., Tateishi Y., Kitada L., Yamamoto Y., Takashima H., Murayama A., Yano T., Baba T., Kato S., Kawabe Y., Yanagisawa J. Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. J. Biol. Chem. 278:2003;26704-26714
11. Glauert H.P., Srinivasan S., Tatum V.L., Chen L.C., Saxon D.M., Lay L.T., Borges T., Chen L.H., Rortson L.W. Effects of peroxisome proliferators ciprofibrate and perfluorodecanoic acid on hepatic cellular antioxidants and lipid peroxidation in rats. Biopchem. Pharmacol. 43(6):1992;1353-1359
12. Gonzales F.J., Peters J.M., Cattley R.C. Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha. J. Natl. Cancer Inst. 90(22):1998;1702-1709
13. 32P -Postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro. Carcinogenesis 6, pp. 933-936.
14. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249:1974;7130-7139
15. Jaiswal A.K., Mcbride O.W., Adesnik M., Nebert D.W. Human dioxin-inducible cytosolic NADP(H):menadione oxidoreductase. cDNA sequence and localization of gene to chromosome. J. Biol. Chem. 263:1988;13572-13578
16. Lake B.G. Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals. Ann. Rev. Pharmacol. Toxicol. 35:1995a;483-507
17. Lake B.G. Peroxisome proliferation: current mechanisms relating to nongenotoxic carcinogenesis. Toxicol. Lett. 82-83:1995;673-681
18. Lee J-M., Anderson P.C., Padgitt J.K., Hanson J.M., Waters C.M. Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element. Biochim. Biophys. Acta. 1629:2003;92-101
19. Li K.M., Todorovic R., Devanesan P., Higginbotham S., Kofeler H., Ramanathan R., Gross M.L., Rogan E.G., Cavalieri E.L. Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3, 4-quinone in vitro and in female ACI rat mammary gland in vivo. Carcinogenesis. 25(2):2004;289-297
20. Li S.A., Weroha S.J., Tawfik O., Li J.J. Prevention of solely estrogen-induced mammary tumors by Tamoxifen: evidence for estrogen receptor mediation. J. Endocrinol. 175(2):2002;297-305
21. Maehara K., Hida T., Abe O.K., Kutoh H. Functional interference between estrogen-related receptor alpha and peroxisome-activated receptor alpha/9-cis-retinoic acid receptor alpha heterodimercomplex in nuclear receptor response element-1 of the medium chain acyl-coenzyme A dehydrogenase gene. J. Mol. Endocrinol. 31:2003;47-60
22. Nilakantan V., Apear B.T., Glauert H.P. Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic mice with elevated hepatic catalase activity. Free Radic. Biol. Med. 24(9):1998;1430-1436
23. Nishimura S., Yokoyama Y., Nakano H., Satoh K., Kano H., Sato K., Tsuchida S. Decreased expression of glutathione S-transferases and increased fatty change in peroxisomal enzyme-negative foci induced by clofibrate in rat livers. Carcinogenesis. 16:1995;1699-1704
24. Nguyen T., Sherrat P.J., Pickett C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Ann. Rev. Pharmacol. Toxicol. 43:2003;233-260
25. Qu B., Li O.T., Wong K.P., Tan T.M., Halliwell B. Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes. Free Radic. Biol. Med. 31(5):2001;659-669
26. Reddy J.K., Azarnoff D.L., Hignite C.E. Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature. 283:1980;397-398
27. Reddy J.K., Scarpelli D.G., Subbarao V., Lalwani N.D. Chemical carcinogens without mutagenic activity: peroxisome proliferators as a prototype. Toxicol. Pathol. 11(2):1983;172-180
28. Reddy J.K., Rao M.S. Oxidative DNA damage caused by persistent peroxisome proliferation: its role in hepatocarcinogenesis. Mutat. Res. 214(1):1989;63-68
29. Rushmore T.H., Morton M.R., Pickett C.B. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J. Biol. Chem. 266(18):1991;11632- 11639
30. Salvador R.A., Haber S., Atkins C., Gommi B.W., Welch R.M. Effect of clofibrate and 1-methyl-4-piperidyl bis (p-chlorophenoxy) acetate (Sandox 42-348) on steroid and drug metabolism by rat liver microsomes. Life Sci. 9(7):1970;397-407
31. Sanchez R.I., Mesia-Vela S., Kauffman F.C. Induction of NAD(P)H quinone oxidoreductase and glutathione S-transferase activities in livers of female August-Copenhagen Irish rats treated chronically with estradiol: comparison to the Sprague-Dawley rat. J. Steroid Biochem. Mol. Biol. 8:2003;199-206
32. Shull J.D., Spady T.J., Snyder M.C., Johansson S.L., Pennington K.L. Ovary-intact, but not ovariectomized female ACI rats treated with 17beta-estradiol rapidly develop mammary carcinoma. Carcinogenesis. 18:1997;1595-1601
33. Spady T.J., Harvell D.M., Lemus-Wilson A., Strecker T.E., Pennington K.L., Vander Woude E.A., Birt D.F., McComb R.D., Shull J.D. Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption. J. Nutr. 129:1999;587S-590S
34. Thomas P.E., Reick L.M., Ryan D.E., Levin W. Induction of two immunochemically related rat liver cytochrome P450 isozymes cytochromes P450c and P450d, by structurally diverse xenobiotics. J. Biol. Chem. 258:1983;4590-4598
35. Wanders R.J., Denis S. Identification of superoxide dismutase in rat liver peroxisomes. Biochim. Biophys. Acta. 1115(3):1992;259-262
36. Xu S., Zhu B.T., Cai M.X., Conney A.H. Stimulatory effect of clofibrate on the action of estradiol in the mammary gland but not in the uterus of rats. J. Pharmacol. Exp. Ther. 297(1):2001a;50-56
37. Xu S., Zhu B.T., Conney A.H. Stimulatory effect of clofibrate and gemfibrozil administration on the formation of fatty acid esters of estradiol by rat liver microsomes. J. Pharmacol. Exp. Ther. 296:2001;188-197
38. Xu S., Zhu B.T., Conney A.H. Effect of clofibrate administration on the esterification and deesterification of steroid hormones by liver and extrahepatic tissues in rats. Biochem. Pharmacol. 63(5):2002;985-992
39. Zacharewski T.R., Meek M.D., Clemons J.H., Wu Z.F., Fielden M.R., Matthews J.B. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Tocicolog. Sci. 46:1998;282-293