Increasing the rate of chromatin remodeling and gene activation - A novel role for the histone acetyltransferase Gcn5

EMBO Journal

Volumn 20, Issue 17, 2001, Pages 4944-4951

  Barbaric, S ^a   Walker, J ^b   Schmid, A ^c   Svejstrup, J Q ^b   Horz W ^c  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

GCN5; Gene regulation; Histone acetylation; PHO5

Indexed keywords

HISTONE ACETYLTRANSFERASE;

ARTICLE; CHROMATIN STRUCTURE; ENZYME ACTIVITY; GENE ACTIVATION; GENE CONTROL; GENETIC TRANSCRIPTION; NONHUMAN; PLASMID; PRIORITY JOURNAL; YEAST;

ACETYLTRANSFERASES; CHROMATIN; DNA-BINDING PROTEINS; ENZYME INDUCTION; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HISTONE ACETYLTRANSFERASES; HISTONES; KINETICS; LUMINESCENT PROTEINS; MEMBRANE TRANSPORT PROTEINS; PHOSPHATE TRANSPORT PROTEINS; PHOSPHATES; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0035801706     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.17.4944     Document Type: Article

References (45)

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9. RNA polymerase II holoenzyme recruitment is sufficient to remodel chromatin at the yeast PH05 promoter
10. Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription
11. Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PH05 promoter in yeast
12. Chromatin remodelling at the PHO8 promoter requires SWI-SNF and SAGA at a step subsequent to activator binding
13. A deletion that includes the signal peptidase cleavage site impairs processing, glycosylation, and secretion of cell surface yeast acid phosphatase
14. Histone acetyltransferase complexes stabilize Swi/Snf binding to promoter nucleosomes
15. The activation domain of a basic helix-loop-helix protein is masked by repressor interaction with domains distinct from that required for transcription regulation
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40. ATP-dependent chromatin-remodeling complexes
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42. Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo
43. A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme