Inhibitory activity of diarylheptanoids on farnesyl protein transferase

Natural Product Research

Volumn 18, Issue 4, 2004, Pages 295-299

  Kang, Hyun Mi ^a,b   Son, Kwang Hee ^a   Yang, Deok Cho ^b   Han, Dong Cho ^a   Kim, Jong Han ^a   Baek, Nam In ^c   Kwon, Byoung Mog ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungbuk National University   (South Korea)

^c Kyung Hee University   (South Korea)

Author keywords

Alnus japonica; Curcuma longa; Diarylheptanoids; Farnesyl protein transferase

Indexed keywords

1,2 DIHYDRO BIS(DE O METHYL)CURCUMIN; 1,7 BIS(3,4 DIMETHOXYPHENYL) 4 METHYLHEPTA 1,6 DIENE 3,5 DIONE BISDIMETHOXYCURCUMIN; ALNUS JAPONICA EXTRACT; BISDIMETHOXYMETHYLCURCUMIN; CARBON 13; CINNAMALDEHYDE DERIVATIVE; CURCUMA LONGA EXTRACT; CURCUMIN; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; HEPTANE DERIVATIVE; METHANOL; PLANT EXTRACT; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTON; UNCLASSIFIED DRUG;

ALDER; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MELTING POINT; PLANT ROOT; PROTON NUCLEAR MAGNETIC RESONANCE;

ALKYL AND ARYL TRANSFERASES; ALNUS; ANIMALS; CURCUMA; DIARYLHEPTANOIDS; FRUIT; INHIBITORY CONCENTRATION 50; PHOSPHONIC ACIDS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS;

ALNUS; ALNUS JAPONICA; CURCUMA; CURCUMA LONGA; JAPONICA;

EID: 2942717081     PISSN: 14786419     EISSN: None     Source Type: Journal    
DOI: 10.1080/14786410310001620691     Document Type: Article

References (9)

1. S.H. Lee, H.K. Kim, J.M. Seo, H.M. Kang, J.H. Kim, K.H. Son, H. Lee and B.M. Kwon. (2002). Journal of Organic Chemistry, 67, 7670-7675.
2. J. Downward (2003). Nature Review Cancer, 3, 11-22.
3. A. Oliff (1999). Biochimica Biophysica Acta, 1423, C19-C30.
4. P.J. Roughley and D.A. Whiting (1973). Journal of Chemical Society Perkin Translation, I, 2379-2388.
5. H. Dong, S.X. Chen, H.X. Zu, S. Kadota and T. Namba (1998). Journal of Natural Product, 61, 142-144.
6. B.M. Kwon, Y.K. Cho, S.H. Lee, J.Y. Nam, S.H. Bok, S.K. Chun, J.A. Kim and I.R. Lee (1996). Planta Medica, 62, 183-184.
7. We did not purify the flavonoids, because the inhibitory activity of flavonoids on FPTase was reported in Planta Med (2003). 69, 218-222.
8. G.I. Gonzalez and J. Zhu (1999). Journal of Organic Chemistry, 64, 914-924.
9. Y. Reiss, M.C. Seabra, J.L. Goldstein and M.S. Brown (1990). Methods: A Comparison to Methods in Enzymology, 1, 241-245.