Antitumor activity of flavones isolated from Artemisia argyi

Planta Medica

Volumn 69, Issue 3, 2003, Pages 218-222

  Seo, Jeong Min ^a   Kang, Hyun Mi ^a   Son, Kwang Hee ^a   Kim, Jong Han ^a   Lee, Chang Woo ^a   Kim, Hwan Mook ^a   Chang, Soo Ik ^b   Kwon, Byoung Mog ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungbuk National University   (South Korea)

Author keywords

Angiogenesis; Artemisia argyi; Compositae; Farnesyl protein transferase; Flavones

Indexed keywords

5,6 DIHYDROXY 7,3',4' TRIMETHOXYFLAVONE; 5,6,4' TRIHYDROXY 7,3' DIMETHOXYFLAVONE; 5,7,3' TRIHYDROXY 6,4',5' TRIMETHOXYFLAVONE; ARTEMISIA ARGYI EXTRACT; DOXORUBICIN; FLAVONE DERIVATIVE; HISPIDULIN; LADANEIN; METHANOL; METHYLEUPATORIN; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTEMISIA; ARTICLE; BODY WEIGHT; CANCER CELL CULTURE; CHICKEN; CHORIOALLANTOIS; COLON CANCER; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; STRUCTURE ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARTEMISIA; CHICK EMBRYO; CHICKENS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; HUMANS; MICE; MICE, NUDE; PHYTOTHERAPY; PLANT EXTRACTS; TUMOR CELLS, CULTURED;

ANIMALIA; ARTEMISIA; ARTEMISIA ARGYI; ASTERACEAE; GALLUS GALLUS; MUS MUSCULUS;

EID: 0037362045     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-38486     Document Type: Article

References (20)

1. Tan RX, Zheng WF, Tang HQ. Biologically active substances from the genus Artemisia. Planta Medica 1988; 64: 295-302
2. Lee SH, Kim MJ, Bok SH, Lee H, Kwon BM, Shin JH, Seo Y. Arteminolide, an inhibitor of farnesyl transferase from Artemisia sylvatica. J Org Chem 1998; 63: 7111-3
3. Lee SH, Kang HM, Song HC, Lee H, Lee UC, Song KH, Kim SH, Kwon BM. Sesquiterpene lactones, inhibitors of farnesyl protein transferase, isolated from the flower of Artemisia sylvatica. Tetrahedron 2000; 56: 4711-5
4. Oliff A. Farnesyltransferase inhibitors: targeting the molecular basis of cancer. Biochim Biophys Acta 1999; 1423: C19-30
5. Adjei AA, Erlichman C, Davis JN, Cutler DL, Sloan JA, Marks RS, Hanson Lj, Svingen PA, Atherton P, Bishop WR, Kirschmeier P, Kaufmann SH. A phase I trial of the farnesyl transferase inhibitor SCH66336: Evidence for biological and clinical activity. Cancer Res 2000; 60: 1871-7
6. Kwon BM, Cho YK, Lee SH, Nam JY, Bok SH, Chun SK, Kim JA, Lee IR. 2′-Hydroxycinnamaldehyde from stem bark of Cinnamomum cassia. Planta Medica 1996; 62: 183-4
7. Kwon BM, Lee SH, Kim KS, Lee IR, Lee UC, Hong SH, Bok SH. Rhombenone: farnesyl transferase inhibitor from the leaves of Hedera rhombea Bean. Bioorg Med Chem Letters 1997; 7: 971-4
8. Kuo SM. Dietary flavonoid and cancer prevention: evidence and potential mechanism. Crit Rev Oncog 1997; 8: 47-69
9. Maldonado E, Ortega A. Neo-clerodane diterpenes from Salvia thymoides. Phytochemistry 1997; 46: 1249-54
10. Bosabalidis A, Gabrieli C, Niopas I. Flavone aglycones in glandular hairs of Origanum x intercedens. Phytochemistry 1998; 49: 1549-54
11. Marco JA, Barbera O, Rodriguez Sa, Domingo C, Adell J. Flavonoids and other phenolics from Artemisia hispanica. Phytochemistry 1998; 27: 3155-60
12. Fan Y, Xing-Cong L, Han-Qing W, Chong-Ren Y. Flavonoid glycosides from Colebrookea oppositifolia. Phytochemistry 1996; 42: 867-9
13. Nakasugi T, Komai K. Antimutagens in the Brazilian folk medicinal plant Carqueja (Baccharis trimera Less.). J Agric Food Chem 1998; 46: 2560-4
14. Kim HM, Han SB, Kim MS, Kang JS, Oh GT, Hong DH. Efficient fixation procedure of human leukemia cells in sulforhodamine B cytotoxicity assay. J Pharmacol Toxicol Methods 1996; 36: 163-9
15. Kwon BM, Lee SH, Cho YK, Bok SH. Synthesis and biological activity of cinnamaldehydes as angiogenesis inhibitors. Bioorg Med Chem Letters 1997; 7: 2473-6
16. Nakasugi T, Nakashima M, Komai K. Antimutagens in Gaiyou. J Agric Food Chem 2000; 48: 3256-66
17. Schinella GR, Giner RM, Recio MC, Mordujovich de Buschiazz P, Rios JL, Manez S. Anti-inflammatory effects of South American Tanacetum vugare. J Pharm Pharmacol 1998; 50: 1069-74
18. Colic M, Pavelic K. Molecular mechanisms of anticancer activity of natural dietetic products. J Mol Med 2000; 78: 333-6
19. Cui B, Lee YH, Chai H, Tucker JC, Fairchild CR, et al. Cytotoxic sesquiterpenoids from Ratibida columnifera. J Nat Prod 1999; 62: 1545-50
20. Fotsis T, Pepper M, Adlercreutz H, Fleischmann G, Hase T, Montesano R, Schweigerer L. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc Natl Acad Sci USA 1993; 90: 2690-4