Discovery, SAR and medicinal chemistry of herpesvirus helicase primase inhibitors

Current Medicinal Chemistry: Anti-Infective Agents

Volumn 3, Issue 1, 2004, Pages 69-83

  Kleymann, Gerald ^a  

^a NONE   (Germany)

Author keywords

Agent; Aminothiazolyl phenyl; Antiviral; BAY 57 1293; BILS 179 BS; BILS 45 BS; Disease; Drug; Helicase; Herpes; HSV; Inhibitor; Primase; Simplex; Thiazolylamide; Treatment

Indexed keywords

ACETAZOLAMIDE; ACICLOVIR; ALPHA INTERFERON; ANTIVIRUS AGENT; BAY 389489; BAY 445138; BAY 513295; BAY 546322; BAY 561655; BAY 571293; CHICKENPOX VACCINE; CYTOTOXIC AGENT; FAMCICLOVIR; HELICASE; PENCICLOVIR; UNCLASSIFIED DRUG; VALACICLOVIR; VIDARABINE;

ANTIVIRAL ACTIVITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; DISEASE COURSE; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS; HERPES VIRUS INFECTION; HUMAN CYTOMEGALOVIRUS; KAPOSI SARCOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; REVIEW; STRUCTURE ACTIVITY RELATION; VARICELLA ZOSTER VIRUS;

EID: 2942710949     PISSN: 15680126     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568012043354242     Document Type: Review

References (56)

1. Knipe, D.M.; Howley, P.M. Fields Virology 4th edition, Lippincott Williams & Wilkins: Philadelphia PA, US, 2001.
2. Kleymann, G. In Herpes Simplex Viruses; Studahl M, Cinque P, Bergstrom T (Ed.) Marcel Dekker Inc. New York USA (2003 in press).
3. Kleymann, G. Expert Opin Investig Drugs (EOID) 2003, 12, 165.
4. Kleymann, G. Drugs of the future, 2003, 28, 257.
5. Kleymann, G. Herpes, 2003, 10, 46.
6. Kaufman, H.E. Proc. Soc. Exp. Biol. Med., 1962, 109, 251.
7. Kaufman, H.E.; Heidelberger, C. Science, 1964, 145, 585.
8. Elion, G.B.; Furman, P.A.; Fyfe, J.A.; de Miranda, P.; Beauchamp, L.; Schaeffer, H.J. Reproduced from Proc. Natl. Acad. Sci. USA, 1977, 74, 5716 Rev Med Virol 1999, 9, 147; discussion 152-153.
9. Schaeffer, H.J.; Beauchamp, L.; de Miranda, P.; Elion, G.B.; Bauer, D.J., Collins, P. Nature, 1978, 272, 583.
10. O'Brien, J.J.; Campoli-Richards, D.M. Acyclovir. Drugs, 1989, 37, 233.
11. Whitley, R.J.; Gnann, J.W. Jr. N. Engl. J. Med., 1992, 327, 782-789. Erratum in: N. Engl. J. Med., 1993, 328, 671 N. Engl. J. Med., 1997, 337, 1703.
12. Öberg, B. Pharmac. Ther., 1989, 40, 213.
13. Beutner, K.R. Antiviral Res., 1995, 28, 281.
14. Perry, C.M.; Faulds, D. Drugs, 1996, 52, 754.
15. Bell, A.R. Adv. Exp. Med. Biol., 1999, 458, 149.
16. Field, H.J. Exp. Opin. Invest. Drugs 1996, 5, 925.
17. Jarvest, R.L.; Sutton, D.; Vere Hodge, R.A. Pharm. Biotechnol., 1998, 11, 313.
18. Gilbert, C.; Bestman-Smith, J.; Boivin, G. Drug Resist. Updat., 2002, 5, 88.
19. Morfin, F.; Thouvenot, D. J. Clin. Virol., 2003, 26, 29.
20. Bacon, T.H.; Levin, M.J.; Leary, J.J.; Sarisky, R.T.; Sutton, D. Clin. Microbiol. Rev., 2003, 16, 114.
21. Crute, J.J.; Lehman, I.R.; Gambino, J.; Yang, T.F.; Medveczky, P.; Medveczky, M.; Khan, N.N.; Mulder, C.; Monroe, J.; Wright, G.E. J. Med. Chem., 1995, 38, 1820.
22. Medveczky, M.; Yang, T.F.; Gambino, J.; Medveczky, P.; Wright, G.E. J. Med. Chem., 1995, 38, 1811.
23. Tatsu, N. JP63060978A Yoshitomi Pharmaceut. Patent Abstracts of Japan, 1988, 12, no 283 (C-518).
24. Dicker, I.B.; Blasecki, J.W.; Seetharam, S. Antiviral Res., 1995, 28, 213.
25. Spector, F.C.; Liang, L.; Giordano, H.; Sivaraja, M.; Peterson, M.G. J. Virol., 1998, 72, 6979.
26. Crute, J.J.; Grygon, C.A.; Hargrave, K.D.; Simoneau, B.; Faucher, A.M.; Bolger, G.; Kibler, P.; Liuzzi, M.; Cordingley, M.G. Nat. Med., 2002, 8, 386.
27. Duan, J.; Liuzzi, M.; Paris, W.; Liard, F.; Browne, A.; Dansereau, N.; Simoneau, B.; Faucher, A.M.; Cordingley, M.G. Antimicrob. Agents Chemother., 2003, 47, 1798.
28. Kleymann, G.; Fischer, R.; Betz, U.A.; Hendrix, M.; Bender, W.; Schneider, U.; Handke, G.; Eckenberg, P.; Hewlett, G.; Pevzner, V.; Baumeister, J.; Weber, O.; Henninger, K.; Keldenich, J.; Jensen, A.; Kolb, J.; Bach; U.; Popp, A.; Mäßen, J.; Frappa, I.; Haebich, D.; Lockhoff, O.; Rübsamen-Waigmann, H. Nat. Med., 2002, 8, 392.
29. Betz, U.A.; Fischer, R.; Kleymann, G.; Hendrix, M.; Rubsamen-Waigmann, H. Antimicrob. Agents Chemother., 2002, 46, 1766.
30. Boehringer Ingelheim CA LTD (CA); Boehringer Ingelheim Pharma (US). Patent WO9724343 & WO0029399. 1997.
31. Kearney. P.C.; Sivaraja, M.; Jaen, J.C.; Fleygare, J.A.; Medina, J.C.; Tularik INC (US). Patent WO9942455. 1999.
32. Fischer, R.; Kleymann, G.; Baumeister, J.; Bender, W.; Betz, U.; Eckenberg, P.; Handke, G.; Hendrix, M.; Schneider, U.; Weber, O.; Henninger, K.; Jensen, A.; Keldenich, J. Patent WO0053591 (PCT/EP/00/01498, EP1161423,DE19959958 A). Bayer AG. 2000.
33. Handke, G.; Baumeister, J.; Bender, W.; Betz, U.; Brands, M.; Eckenberg, P.; Fischer, R.; Hendrix, M.; Henninger, K.; Jensen, A.; Keldenich, J.; Kleymann, G.; Mäßen, J.; Schneider, U.; Weber, O. WO0076966 (PCT/EP00/05114; DE19927415). Bayer AG. 2000.
34. Fischer, R.; Kleymann, G.; Betz, U.; Baumeister, J.; Bender, W.; Eckenberg, P.; Handke, G.; Hendrix, M.; Henninger, K.; Jensen, A.; Keldenich, J.; Schneider, U.; Weber, O. WO0147904 (PCT/EP/00/12564, EP1244641, DE19962532 A, DE10039265 A), WO03000259 (PCT/EP02/06327, DE10129714 A), WO03000260 (PCT/EP02/06324, DE10129715 A). Bayer AG. 2001.
35. Kleymann, G.; Fischer, R.; Betz, U.; Hendrix, M.; Schohe-Loop, R.; Baumeister, J.; Bender, W.; Eckenberg, P.; Handke, G.; Henninger, K.; Jensen, A.; Keldenich, J.; Schneider, U.; Weber, O. WO03007946(PCT/EP/02/06697, DE10131128 A). Bayer AG. 2003.
36. Hendrix, M.; Kleymann, G.; Betz, U.; Baumeister, J.; Bender, W.; Eckenberg, P.; Fischer, R.; Handke, G.; Henninger, K.; Jensen, A.; Keldenich, J.; Schneider, U.; Weber, O. DE10044358 A. Bayer AG. 2002.
37. Hendrix, M.; Kleymann, G.; Betz, U.; Baumeister, J.; Bender, W.; Eckenberg, P.; Fischer, R.; Handke, G.; Henninger, K.; Jensen, A.; Keldenich, J.; Schneider, U.; Weber, O. WO0212211 (DE10038022 A). Bayer AG. 2002.
38. Bender, W.; Kleymann, G.; Betz, U.; Baumeister, J.; Eckenberg, P.; Fischer, R.; Handke, G.; Hendrix, M.; Henninger, K.; Jensen, A.; Keldenich, J.; Schneider, U.; Weber, O. DE10044328 A. Bayer AG. 2002.
39. Kleymann, G.; Betz, U.; Fischer, R.; Hendrix, M.; Hewlett, G.; Pevzner, V. WO0196874 (PCT/EP00/05509, EP1319185). Bayer AG. 2001.
40. Kleymann, G.; Fischer, R.; Hendrix, M.; Hewlett, G.; Pevzner, V.; Betz, U.; Bender, W.; Eckenberg, P.; Handke, G.; Schneider, U.; Weber, O.; Henninger, K.; Jensen, A.; Keldenich, J.; Baumeister, J. WO0220014 (PCT/EP01/09843, DE10044353 A). Bayer AG. 2002.
41. Kleymann, G.; Betz, U.; Fischer, R.; Hendrix, M.; Bender, W.; Eckenberg, P.; Handke, G.; Schneider, U.; Schohe-Loop, R.; Baumeister, J.; Henninger, K.; Jensen, A.; Keldenich, J.; Weber, O. Patent application DE10129717 A & DE10129716. Bayer AG. 2003.
42. Boehmer, P.E.; Nimonkar, A. V. IUBMB Life., 2003, 55, 13.
43. Lehman, I.R.; Boehmer, P.E. J. Biol. Chem., 1999, 274, 28059.
44. Matthews, J.T.; Terry, B.J.; Field, A.K. Antiviral Res., 1993, 20, 89.
45. Falkenberg, M.; Elias, P.; Lehman, I.R. J. Biol. Chem., 1998, 273, 32154.
46. Crute, J.J.; Lehman, I.R. J. Biol. Chem., 1991, 266, 4484.
47. Crute, J.J.; Tsurumi, T.; Zhu, L.A.; Weller, S.K.; Olivo, P.D.; Challberg, M.D.; Mocarski, E.S.; Lehman, I.R. Proc. Natl. Acad. Sci. USA, 1989, 86, 2186.
48. Mitchell, B.M.; Bloom, D.C.; Cohrs, R.J.; Gilden, D.H.; Kennedy, P.G. J. Neurovirol., 2003, 9, 194.
49. Koelle, D.M.; Corey, L. Clin. Microbiol. Rev., 2003, 16, 96.
50. Shin, Y.K.; Cai, G.-Y.; Weinberg, A.; Leary, J.J.; Levin, M.J. J. Clin. Microbiol., 2001, 39, 913.
51. Durand-Cavagna, G.; Owen, R.A.; Gordon, L.R.; Peter, C.P.; Boussiquet-Leroux, C. U. Fundam. Appl. Toxicol., 1992, 18, 137.
52. Lankas, G.R.; Peter, C.P. Food. Chem. Toxicol., 1992, 30, 297.
53. Molon-Noblot, S.; Boussiquet-Leroux, C.; Owen, R.A.; Irisarri, E.; Durand-Cavagna, G.; Peter, C.P.; Duprat, P. Toxicol. Pathol., 1992, 20, 93.
54. Spicer, S.S.; Ge, Z.H.; Siegel, G.J. Lab. Invest., 1987, 57, 535.
55. Bagnis, C.; Marshansky, V.; Breton, S.; Brown, D. Am. J. Physiol. Renal Physiol., 2001, 280, F437-F448.
56. Owen, R.A.; Durand-Cavagna, G.; Molon-Noblot, S.; Boussiquet-Leroux, C.; Berry, P.H.; Tonkonoh, N.; Peter, C.P.; Gordon, L.R. Toxicol. Pathol., 1993, 21, 449.