Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex

Journal of Virology

Volumn 72, Issue 9, 1998, Pages 6979-6987

  Spector, F C ^a   Liang, L ^a   Giordano, H ^a   Sivaraja, M ^a   Peterson, M G ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOTHIAZOLE DERIVATIVE; HELICASE; T 157602; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; FIBROBLAST CULTURE; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; VERO CELL; VIRUS INHIBITION; VIRUS REPLICATION;

EID: 0031846516     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.9.6979-6987.1998     Document Type: Article

References (63)

1. Bush, M., D. R. Yager, M. Gao, K. Weisshart, A. I. Marcey, D. M. Coen, and D. Knipe. 1991. Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA binding protein. J. Virol. 65: 1082-1089.
2. Calder, J. M., and N. D. Stow. 1990. Herpes simplex virus helicase-primase: the UL8 protein is not required for DNA dependent ATPase and DNA helicase activities. Nucleic Acids Res. 18:3573-3578.
3. Calder, J. M., E. C. Stow, and N. D. Stow. 1992. On the cellular localization of the components of the herpes simplex virus type 1 helicase-primase complex and the viral origin-binding protein. J. Gen. Virol. 73:531-538.
4. Chartrand, P., C. S. Crumpacker, P. A. Schaffer, and N. M. Wilkie. 1980. Physical and genetic analysis of the herpes simplex DNA polymerase locus. Virology 103:311-326.
5. Coen, D. M. 1986. General aspects of virus drug resistance with special reference to herpes simplex virus. J. Antimicrob. Chemother. 18:1-10.
6. Coen, D. M. 1990. Antiviral drug resistance. Ann. N. Y. Acad. Sci. USA 616: 224-237.
7. Coen, D. M. 1994. Acyclovir resistant, pathogenic herpes viruses. Trends Microbiol. 2:481-485.
8. Coen, D. M., D. P. Aschmann, P. T. Gelep, M. J. Retondo. S. K. Weller, and P. A. Schaffer. 1984. Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus. J. Virol. 49:236-247.
9. Coen, D. M., M. Kosz-Vnenchak, J. G. Jacobsen, D. A. Leib, et al. 1989. Thymidine kinase negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc. Natl. Acad. Sci. USA 86:4736-4740.
10. Crute, J. J., and I. R. Lehman. 1989. Herpes simplex virus-1 DNA polymerase. Identification of an intrinsic 5' to 3' exonuclease with ribonucleaseH activity. J. Biol. Chem. 264:19266-19270.
11. Crute, J. J., and I. R. Lehman. 1991. Herpes simplex virus helicase:primase. Physical and catalytic properties. J. Biol. Chem. 266:4484-4488.
12. Crute, J. J., L. Tsurumi, L. Zhu, S. K. Weller, P. D. Olivio, E. S. Mocarski, M. D. Challberg, and I. R. Lehman. 1989. Herpes simplex virus 1 helicase-primase: a complex of three herpes encoded gene products. Proc. Natl. Acad. Sci. USA 86:2186-2189.
13. Dodson, M. S., and I. R. Lehman. 1991. Overexpression and assembly of the herpes simplex virus type 1 helicase-primase in insect cells. J. Biol. Chem. 264:20835-20838.
14. Elias, P., and I. R. Lehman. 1988. Interaction of origin binding protein with an origin of replication of herpes simplex type 1. Proc. Natl. Acad. Sci. USA 85:2959-2963.
15. Elias, P., M. E. O'Donnell, E. S. Mocarski, and I. R. Lehman. 1986. A DNA binding protein specific for an origin of replication of herpes simplex virus type 1. Proc. Natl. Acad. Sci. USA 86:6322-6326.
16. Falkenberg, M., D. A. Bushnell, and P. Elias. 1997. The UL8 subunit of the heterotrimeric herpes simplex virus type 1 helicase primase is required for the unwinding of single strand DNA binding protein (ICP8) coated DNA substrate. J. Biol. Chem. 272:22766-22770.
17. Fierer, D. S., and M. D. Challberg. 1992. Purification and characterization of UL9, the herpes simplex virus type 1 origin-binding protein. J. Virol. 66: 3986-3995.
18. Gallo, M. L., D. I. Dorsky, C. S. Crumpacker, and D. S. Parris. 1989. The essential 65-kilodalton DNA binding protein of herpes simplex virus stimulates the virus-encoded DNA polymerase. J. Virol. 63:5023-5029.
19. Gallo, M. L., D. H. Jackwood, M. Murphy, H. S. Marsden, and D. S. Parris. 1988. Purification of the herpes simplex virus type 1 65-kilodalton DNAbinding protein: properties of the protein and evidence of its association with the virus-encoded DNA polymerase. J. Virol. 62:2874-2883.
20. Gorbalenya, A. E., E. V. Koonin, A. P. Donchenko, and V. M. Blinov. 1988. A novel superfamily of nucleoside triphosphate binding motif containing proteins which are probably involved in duplex unwinding in DNA and RNA replication and recombination. FEBS Lett. 235:16-24.
21. Gottlieb, J., A. I. Marcy, D. M. Coen, and M. D. Challberg. 1990. The herpes simplex virus type 1 gene product: a subunit of DNA polymerase that functions to increase processivity. J. Virol. 64:5976-5987.
22. Hall, J. D., D. M. Coen, B. L. Fisher, M. Weisslitz, R. E. Almy, P. T. Gelep, and P. A. Schaffer. 1984. Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. Virology 132:26-37.
23. Hall, J. D., P. A. Furman, M. H. St. Clair, and C. W. Knopf. 1985. Reduced in vivo mutagenesis by mutant herpes simplex DNA polymerase involves improved nucleotide selection. Proc. Natl. Acad. Sci. USA 82:3889-3893.
24. Hernandez, T. R., and I. R. Lehman. 1990. Functional interactions between the herpes simplex-1 DNA polymerase and the UL42 protein. J. Biol. Chem. 265:11227-11232.
25. Hodgeman, T. C. 1988. A new superfamily of replicative proteins. Nature (London) 333:22-23.
26. 25a.Kern, E. Personal communication.
27. Kimberlin, D. W., D. M. Coen, K. K. Biron, J. I. Cohen, R. A. Lamb, M. McKinlay, E. A. Emini, and R. J. Whitley. 1995. Molecular mechanisms of antiviral resistance. Antiviral Res. 26:369-401.
28. Klinedinst, D. K., and M. D. Challberg. 1994. Helicase-primase complex of herpes simplex virus type 1: a mutation in the UL52 subunit abolishes primase activity. J. Virol. 68:3693-3701.
29. Lanzetta, P. A., L. J. Alvarez, P. S. Reinach, and O. A. Candia. 1979. An improved assay for nanomole amounts of inorganic phosphate. Anal. Biochem. 100:95-97.
30. Marians, K. J. 1997. Helicase structures: a new twist on DNA unwinding. Structure 5:1129-1137.
31. Marsden, H. S., A. M. Cross, G. J. Francis, A. H. Patel, K. A. MacEachran, M. Murphy, G. L. McVey, D. Haydon, A. Abbotts, and N. D. Stow. 1996. The herpes simplex type 1 UL8 protein influences the intracellular localization of the UL52 but not the ICP8 or POL replication proteins in virus infected cells. J. Gen. Virol. 77:2241-2249.
32. Marsden, H. S., G. W. McLean, E. C. Barnard, G. J. Francis, K. MacEachran, M. Murphy, G. McVey, A. Cross, A. P. Abbotts, and N. D. Stow. 1997. The catalytic subunit of the DNA polymerase of herpes simplex type 1 interacts specifically with the C terminus of the UL8 component of the viral helicase-primase complex. J. Virol. 71:6390-6397.
33. McGeoch, D. J., M. A. Dalrymple, A. Dolan, D. McNab, L. J. Perry, P. Taylor, and M. D. Challberg. 1988. Structures of the herpes simplex type 1 genes required for virus DNA replication. J. Virol. 62:444-453.
34. McLean, G., A. Abbots, M. E. Parry, H. S. Marsden, and N. D. Stow. 1994. The herpes simplex virus type 1 origin binding protein interacts specifically with the viral UL8 protein. J. Gen. Virol. 75:2699-2706.
35. Olivo, P. D., N. J. Nelson, and M. D. Challberg. 1989. Herpes simplex virus type 1 gene products required for DNA replication: identification and overexpression. J. Virol. 63:196-204.
36. Olivo, P. D., N. J. Nelson, and M. D. Challberg. 1988. Herpes simplex virus DNA replication: the UL9 gene encodes an origin binding protein. Proc. Natl. Acad. Sci. USA 85:5414-5418.
37. O'Reilly, D. R., L. K. Miller, and V. A. Luckow. 1992. Baculovirus expression vectors: a laboratory manual. W. H. Freeman & Co., New York, N.Y.
38. Parris, D. S., C. A., L. Harr, A. Orr, M. C. Frame, M. Murphy, D. J. McGeoch, and H. S. Marsden. 1988. Identification of the gene encoding the 65-kilodalton DNA binding protein of herpes simplex type 1. J. Virol. 62: 894-902.
39. Parry, M. E., N. D. Stow, and H. S. Marsden. 1993. Purification and properties of the herpes simplex virus type 1 UL8 protein. J. Gen. Virol. 74:607-612.
40. Pelosi, E., K. A. Hicks, S. L. Sacks, and D. M. Coen. 1992. Heterogeneity of a herpes simplex virus clinical isolate exhibiting resistance to ACV and foscarnet. Adv. Exp. Med. Biol. 312:151-158.
41. Powell, K. L., E. Littler, and D. J. M. Purifoy. 1981. Nonstructural proteins of herpes simplex virus. II. Major virus-specific DNA-binding protein. J. Virol. 39:894-902.
42. Purves, F. C., and B. Roizman. 1992. The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein α22. Proc. Natl. Acad. Sci. USA 89:7310-7314.
43. Roizman, B., and A. E. Sears. 1996. Herpes simplex viruses and their replication, p. 2231-2295. In B. N. Fields, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Fields virology, 3rd ed., vol. 2. Lippincott-Raven, New York, N.Y.
44. Sherman, G., J. Gottlieb, and M. D. Challberg. 1992. The UL8 subunit of the herpes simplex helicase-primase complex is required for efficient primer utilization. J. Virol. 66:4884-4892.
45. 43a.Sivaraja, M. Unpublished data.
46. Spaete, R., and N. Frenkel. 1982. The herpes simplex amplicon: a new eucaryotic defective virus cloning-amplifying vector. Cell 30:295-304.
47. Spaete, R. R., and N. Frenkel. 1985. The herpes simplex virus amplicon: analyses of cis acting replication functions. Proc. Natl. Acad. Sci. USA 82: 694-698.
48. Spector, D., F. C. Purves, R. King, and B. Roizman. 1993. Regulation of α and γ gene expression in cells infected with herpes simplex 1, p. 25-42. Plenum, New York, N.Y.
49. Stow, N. D. 1982. Localization of an origin of DNA replication within the TRS/IRS repeated region of herpes simplex virus type 1. EMBO J. 1:863-867.
50. Stow, N. D., and E. C. McMonagle. 1983. Characterization of the TRS/IRS origin of DNA replication of herpes simplex virus type 1. Virology 130:427-438.
51. Tenney, D. J., W. W. Hurlburt, P. A. Micheletti, M. Bifano, and R. K. Hamatake. 1993. The UL8 component of the herpes simplex virus helicase-primase complex stimulates primer synthesis by a subassembly of the UL5 and UL52 components. J. Biol. Chem. 269:5030-5035.
52. Vlazny, D. A., and N. Frenkel. 1981. Replication of herpes simplex virus DNA: localization of replication recognition signals within defective virus genomes. Proc. Natl. Acad. Sci. USA 78:742-746.
53. Walboomers, J. M., and J. Ter Schagget. 1976. A new method for the isolation of herpes simplex virus type 2 DNA. Virology 74:256-258.
54. Walker, J. E., M. Saraste, M. J. Runswicke, and N. J. Gay. 1982. Distantly related sequences in the A and B subunits of ATP synthetase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1:945-951.
55. Weller, S. K., K. J. Lee, D. J. Sabourin, and P. A. Schaffer. 1983. Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein. J. Virol. 45:354-366.
56. Weller, S. K., A. Spadaro, J. E. Schaffer, A. W. Murray, A. M. Maxam, and P. A. Scahffer. 1985. Cloning, sequencing and functional analysis of oriL, a herpes simplex type 1 origin of DNA synthesis. Mol. Cell. Biol. 5:930-942.
57. Whitley, R. J. 1996. Herpes simplex viruses, p. 2297-2342. In B. N. Fields, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman, and S. E. Straus (ed.), Fields virology, 3rd ed., vol. 2. Lippincott-Raven, New York, N.Y.
58. Whitley, R. J., and J. W. Gnann. 1992. Acyclovir: a decade later. N. Engl. J. Med. 327:782-789.
59. Whitley, R. J., and J. W. Gnann, Jr. 1993. The epidemiology and clinical manifestations of herpes simplex virus infections, p. 69-105. In B. Roizman, R. J. Whitley, and C. Lopez (ed.), The human herpesviruses, vol. 3. Raven Press, New York, N.Y.
60. Whitley, R. J., E. R. Kern, S. Chatterjee, J. Chou, and B. Roizman. 1993. Replication, establishment of latency, and induced reactivation of herpes simplex virus γ-1 34.5 deletion mutants in rodent models. J. Clin. Invest. 91: 2837-2843.
61. Wu, C. A., N. Nelson, D. J. McGeoch, and M. D. Challberg. 1988. Identification of herpes simplex virus type 1 genes required for origin dependent DNA synthesis. J. Virol. 62:435-443.
62. Zhu, L., and S. K. Weller. 1988. UL5, a protein required for HSV DNA synthesis: genetic analysis, overexpression in Escherichia coli, and generation of polyclonal antibodies. Virology 166:366-378.
63. Zhu, L., and S. K. Weller. 1992. The six conserved helicase motifs of the UL5 gene product, a component of the herpes simplex virus type 1 helicase-primase, are essential for its function. J. Virol. 66:469-479.