Achiral phenolic N-oxides as additives: An alternative strategy for asymmetric cyanosilylation of ketones

Tetrahedron Letters

Volumn 45, Issue 28, 2004, Pages 5465-5467

  He, Bin ^a   Chen, Fu Xue ^a   Li, Yan ^a   Feng, Xiaoming ^a   Zhang, Guolin ^b  

^a SICHUAN UNIVERSITY   (China)

^b CHENGDU INSTITUTE OF BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

KETONE DERIVATIVE; TITANIUM;

ADDITION REACTION; ARTICLE; ASYMMETRIC CATALYSIS; CATALYSIS; CHEMICAL REACTION; CHIRALITY; REACTION ANALYSIS; SILYLATION;

EID: 2942635053     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.05.069     Document Type: Article

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33. 2 atmosphere. To this solution, acetophenone (58 μL, 0.5 mmol) was added at -20°C, followed by the addition of TMSCN (137 μL, 1 mmol). After 96 h, the solution was concentrated and the residue was purified by silica gel column chromatography giving the product with 94% yield and 81% ee that was determined by Chiral GC analysis on Chirasil DEX CB