Homochiral Amine Oxides in the Enantioselective Reduction of Ketones

Synlett

Volumn 1997, Issue 7, 1997, Pages 777-780

  O'Neil, Ian A ^a   Turner, Carl D ^a   Kalindjian, S Barret ^b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b James Black Foundation   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 1542639827     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1997-5770     Document Type: Article

References (21)

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7. Karayannis, N. M.; Pytlewski, L. L.; Mikulski, C. M. Coord. Chem. Rev., 1973, 11, 93. Holm, R. H. Chem. Rev., 1987, 87, 1401. Albini, A. Synthesis, 1993, 263.
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20. Full crystallographic data will be deposited at the Cambridge Crystallographic Data Centre. We would like to thank Mr J. V. Barkley (University of Liverpool) for carrying out these structure determinations.
21. 2. The solvent was allowed to evaporate overnight. Each reaction was run in triplicate and the ee given is an average of the three runs. Analysis was performed on a Phillips PU 4600 gas chromatograph using a Lipodex A column (25m × 0.25 μm, 0.6 bar, 75°C), or a Chiraldex GTA column (0.6 bar, 70°C). On the Lipodex A column, the retention time for (R)-2-chloro-1-phenyl-1-ethanol trifluoroacetate is 46.05 minutes and for (S)-2- chloro-1-phenyl-1-ethanol trifluoroacetate is 45.17 minutes. All compounds gave correct spectroscopic and analytical data.