메뉴 건너뛰기




Volumn 7, Issue 2, 2004, Pages 79-87

New cancer therapeutics: Target-specific in, cytotoxics out?

Author keywords

(Phospho)proteomics; AEE788; Biomarkers; CI 1040; Erlotinib; Gefitinib; Gleevec; Imatinib; Iressa; PD0325901; Protein kinase inhibitors; SU 11248; SU 5416; Tarceva; Target selection; Trastuzumab; Xyotax; ZD1839; ZM447439

Indexed keywords

17 ALLYLAMINOGELDANAMYCIN; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; CAPECITABINE; CYTOTOXIC AGENT; DOCETAXEL; ERLOTINIB; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GELDANAMYCIN; IMATINIB; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; OXALIPLATIN; PACLITAXEL; PACLITAXEL POLIGLUMEX; POLYGLUTAMIC ACID; PROTEIN TYROSINE KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; SEMAXANIB; SORAFENIB; SUNITINIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE; [4 [2 CYCLOPENTYL 9 (3 HYDROXYPHENETHYL)PURIN 6 YLAMINO]PHENYL]DIMETHYLPHOSPHINE OXIDE;

EID: 2942627403     PISSN: 13687646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drup.2004.02.004     Document Type: Conference Paper
Times cited : (23)

References (59)
  • 1
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor β in preclinical models of human small cell lung cancer
    • Abrams, T.J., Lee, L.B., Murray, L.J., Pryer, N.K., Cherrington, J.M., 2003. SU11248 inhibits KIT and platelet-derived growth factor receptor β in preclinical models of human small cell lung cancer. Mol. Cancer Ther. 2, 471-478.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 2
    • 0037879057 scopus 로고    scopus 로고
    • The interface between Erb and non-Erb receptors in tumor invasion: Clinical implications and opportunities for target discovery
    • Alaoui-Jamali, M.A., Qiang, H., 2003. The interface between Erb and non-Erb receptors in tumor invasion: clinical implications and opportunities for target discovery. Drug Resist. Update 6, 95-107.
    • (2003) Drug Resist. Update , vol.6 , pp. 95-107
    • Alaoui-Jamali, M.A.1    Qiang, H.2
  • 3
    • 85030877971 scopus 로고    scopus 로고
    • B153 Molecular mechanism of Gleevec resistance revealed by the mutagenesis of BCR/ABL gene
    • abstract B153
    • Azam, M., Daley, G.Q., 2003. B153 Molecular mechanism of Gleevec resistance revealed by the mutagenesis of BCR/ABL gene. Clin. Cancer Res. 9 (16 Suppl.), 6174S (abstract B153).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Azam, M.1    Daley, G.Q.2
  • 4
    • 0037459344 scopus 로고    scopus 로고
    • Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
    • Azam, M., Latek, R.R., Daley, G.Q., 2003. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell 112, 831-843.
    • (2003) Cell , vol.112 , pp. 831-843
    • Azam, M.1    Latek, R.R.2    Daley, G.Q.3
  • 5
    • 85030886746 scopus 로고    scopus 로고
    • Characterization of a novel class of aurora-2 kinase inhibitors
    • abstract A12
    • Bashyam, S., Warner, S.L., Vankayalapati, H., et al., 2003. Characterization of a novel class of aurora-2 kinase inhibitors. Clin. Cancer Res. 9 (16 Suppl.), 6071S-6072S (abstract A12).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Bashyam, S.1    Warner, S.L.2    Vankayalapati, H.3
  • 6
    • 8944261743 scopus 로고    scopus 로고
    • Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations
    • Beck, W.T., Grogan, T.M., Willman, C.L., et al., 1996. Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res. 56, 3010-3020.
    • (1996) Cancer Res. , vol.56 , pp. 3010-3020
    • Beck, W.T.1    Grogan, T.M.2    Willman, C.L.3
  • 7
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E., Hanahan, D., 2003. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111, 1287-1295.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 8
    • 0029999404 scopus 로고    scopus 로고
    • How to probe clinical tumour samples for P-glycoprotein and multidrug-resistance-associated protein
    • Broxterman, H.J., Lankelma, J., Pinedo, H.M., 1996. How to probe clinical tumour samples for P-glycoprotein and multidrug-resistance-associated protein. Eur. J. Cancer 32A, 1024-1033.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 1024-1033
    • Broxterman, H.J.1    Lankelma, J.2    Pinedo, H.M.3
  • 9
    • 0038713666 scopus 로고    scopus 로고
    • Resistance to cytotoxic and anti-angiogenic agents: Similarities and differences
    • Broxterman, H.J., Lankelma, J., Hoekman, K., 2003. Resistance to cytotoxic and anti-angiogenic agents: similarities and differences. Drug Resist. Update 6, 111-127.
    • (2003) Drug Resist. Update , vol.6 , pp. 111-127
    • Broxterman, H.J.1    Lankelma, J.2    Hoekman, K.3
  • 10
    • 0642276783 scopus 로고    scopus 로고
    • Epidermal growth factor receptor overexpression: The importance of context
    • Carbone, D.P., 2003. Epidermal growth factor receptor overexpression: the importance of context. J. Clin. Oncol. 21, 4268-4269.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4268-4269
    • Carbone, D.P.1
  • 11
    • 0037699294 scopus 로고    scopus 로고
    • Strategies to target HER2/neu overexpression for cancer therapy
    • Chen, J.-S., Lan, K., Hung, M.-C., 2003. Strategies to target HER2/neu overexpression for cancer therapy. Drug Resist. Update 6, 129-136.
    • (2003) Drug Resist. Update , vol.6 , pp. 129-136
    • Chen, J.-S.1    Lan, K.2    Hung, M.-C.3
  • 12
    • 85030878015 scopus 로고    scopus 로고
    • A novel consensus motif in fibronectin mediates dipeptidyl peptidase IV adhesion and metastasis
    • abstract B188
    • Cheng, H.-C., Abdel-Ghany, M., Pauli, B., 2003. A novel consensus motif in fibronectin mediates dipeptidyl peptidase IV adhesion and metastasis. Clin. Cancer Res. 9 (16 Suppl.), 6182S-6183S (abstract B188).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Cheng, H.-C.1    Abdel-Ghany, M.2    Pauli, B.3
  • 13
    • 85030876185 scopus 로고    scopus 로고
    • Structure-based design and X-ray crystallographic analysis of a potent and selective Src tyrosine kinase inhibitor for the treatment of cancer
    • abstract A5
    • Dalgarno, D.C., Bohacek, R., Stehle, T., et al., 2003. Structure-based design and X-ray crystallographic analysis of a potent and selective Src tyrosine kinase inhibitor for the treatment of cancer. Clin. Cancer Res. 9 (16 Suppl.), 6070S (abstract A5).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Dalgarno, D.C.1    Bohacek, R.2    Stehle, T.3
  • 14
    • 24844439718 scopus 로고    scopus 로고
    • ZM447439, a novel Aurora kinase inhibitor, prevents chromosome alignment and compromises spindle checkpoint function in human cells
    • abstract A279
    • Ditchfield, C., Johnson, V.L., Taylor, S.S., et al., 2003a. ZM447439, a novel Aurora kinase inhibitor, prevents chromosome alignment and compromises spindle checkpoint function in human cells. Clin. Cancer Res. 9 (16 Suppl.), 6138S (abstract A279).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Ditchfield, C.1    Johnson, V.L.2    Taylor, S.S.3
  • 15
    • 0013057087 scopus 로고    scopus 로고
    • Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
    • Ditchfield, C., Johnson, V.L., Tighe, A., et al., 2003b. Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J. Cell Biol. 161, 267-280.
    • (2003) J. Cell Biol. , vol.161 , pp. 267-280
    • Ditchfield, C.1    Johnson, V.L.2    Tighe, A.3
  • 16
    • 0035735754 scopus 로고    scopus 로고
    • Role of mitogen-activated kinases in the response of tumor cells to chemotherapy
    • Fan, M., Chambers, T.C., 2001. Role of mitogen-activated kinases in the response of tumor cells to chemotherapy. Drug Resist. Update 4, 253-267.
    • (2001) Drug Resist. Update , vol.4 , pp. 253-267
    • Fan, M.1    Chambers, T.C.2
  • 17
    • 0036815597 scopus 로고    scopus 로고
    • P53 as a therapeutic target: Unresolved issues on the road to cancer therapy targeting mutant p53
    • Fojo, T., 2002. P53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53. Drug Resist. Update 5, 209-216.
    • (2002) Drug Resist. Update , vol.5 , pp. 209-216
    • Fojo, T.1
  • 18
    • 0842290920 scopus 로고    scopus 로고
    • New directions in cancer research 2003: Technological advances in biology, drug resistance, and molecular pharmacology
    • Franks, M.E., Macpherson, G.R., Lepper, E.R., Figg, W.D., Sparreboom, A., 2003. New directions in cancer research 2003: technological advances in biology, drug resistance, and molecular pharmacology. Drug Resist. Update 6, 301-375.
    • (2003) Drug Resist. Update , vol.6 , pp. 301-375
    • Franks, M.E.1    Macpherson, G.R.2    Lepper, E.R.3    Figg, W.D.4    Sparreboom, A.5
  • 19
    • 0012381722 scopus 로고    scopus 로고
    • A multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small lung cancer (The IDEAL 1 Trial)
    • Fukuoa, M., Yano, S., Giaccone, G., et al., 2003. A multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small lung cancer (The IDEAL 1 Trial). J. Clin. Oncol. 21, 2237-2246.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2237-2246
    • Fukuoa, M.1    Yano, S.2    Giaccone, G.3
  • 20
    • 0036814435 scopus 로고    scopus 로고
    • Clinical cancer research 2002: New agents and therapies
    • Gietema, J.A., de Vries, E.G.E., 2002. Clinical cancer research 2002: new agents and therapies. Drug Resist. Update 5, 192-203.
    • (2002) Drug Resist. Update , vol.5 , pp. 192-203
    • Gietema, J.A.1    De Vries, E.G.E.2
  • 21
    • 85030874569 scopus 로고    scopus 로고
    • Combination therapy of inhibitors of the epidermal growth factor/ vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition
    • abstract A88
    • Goudar, R., Keir, S., Hjelmeland, M., et al., 2003. Combination therapy of inhibitors of the epidermal growth factor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Clin. Cancer Res. 9 (16 Suppl.), 6090S (abstract A88).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Goudar, R.1    Keir, S.2    Hjelmeland, M.3
  • 22
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., Weinberg, R.A., 2000. The hallmarks of cancer. Cell 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 23
    • 0037434981 scopus 로고    scopus 로고
    • Disease proteomics
    • Hanash, S., 2003. Disease proteomics. Nature 422, 226-232.
    • (2003) Nature , vol.422 , pp. 226-232
    • Hanash, S.1
  • 24
    • 0344626925 scopus 로고    scopus 로고
    • A myristoyl/phosphotyrosine switch regulates c-Abl
    • Hantschel, O., Nagar, B., Guettler, S., et al., 2003. A myristoyl/phosphotyrosine switch regulates c-Abl. Cell 112, 845-857.
    • (2003) Cell , vol.112 , pp. 845-857
    • Hantschel, O.1    Nagar, B.2    Guettler, S.3
  • 25
    • 0036216651 scopus 로고    scopus 로고
    • Unraveling the complexities of the Raf/MAPkinase pathway for pharmacological intervention
    • Herrera, R., Sebolt-Leopold, J.S., 2002. Unraveling the complexities of the Raf/MAPkinase pathway for pharmacological intervention. Trends Mol. Med. 8, S27-S31.
    • (2002) Trends Mol. Med. , vol.8
    • Herrera, R.1    Sebolt-Leopold, J.S.2
  • 26
    • 0347364778 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in non-small cell lung cancer
    • Herbst, R., Bunn, Jr., P.A., 2003. Targeting the epidermal growth factor receptor in non-small cell lung cancer. Clin. Cancer Res. 9, 5813-5824.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5813-5824
    • Herbst, R.1    Bunn Jr., P.A.2
  • 27
    • 0347364770 scopus 로고    scopus 로고
    • Is KIT an important therapeutic target in small cell lung cancer?
    • Heinrich, M.C., 2003. Is KIT an important therapeutic target in small cell lung cancer? Clin. Cancer Res. 9, 5825-5828.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5825-5828
    • Heinrich, M.C.1
  • 28
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch, F., Varella-Garcia, M., Bunn, P.A., 2003. Epidermal growth factor receptor in non-small cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J. Clin. Oncol. 21, 3798-3807.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3798-3807
    • Hirsch, F.1    Varella-Garcia, M.2    Bunn, P.A.3
  • 29
    • 0842304140 scopus 로고    scopus 로고
    • Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis
    • Huang, J., Soffer, S.Z., Kim, E.S., et al., 2004. Vascular remodeling marks tumors that recur during chronic suppression of angiogenesis. Mol. Cancer Res. 2, 36-42.
    • (2004) Mol. Cancer Res. , vol.2 , pp. 36-42
    • Huang, J.1    Soffer, S.Z.2    Kim, E.S.3
  • 30
    • 9144230676 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with small cell lung cancer
    • Johnson, B.E., Fischer, T., Fischer, B., et al., 2003. Phase II study of imatinib in patients with small cell lung cancer. Clin. Cancer Res. 9, 5880-5887.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5880-5887
    • Johnson, B.E.1    Fischer, T.2    Fischer, B.3
  • 31
    • 24744469113 scopus 로고    scopus 로고
    • Final evaluation of Tarceva (Erlotinib) in combination with FOLFOX4 in patients with solid tumors
    • abstract A108
    • Jones, R.J., Hanauske, A., Diaz-Rubio, E., et al., 2003. Final evaluation of Tarceva (Erlotinib) in combination with FOLFOX4 in patients with solid tumors. Clin. Cancer Res. 9 (16 Suppl.), 6095S (abstract A108).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Jones, R.J.1    Hanauske, A.2    Diaz-Rubio, E.3
  • 32
    • 0038713433 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells
    • Kajiyama, H., Kikkawa, F., Khin, E., Shibata, K., Ino, K., Mizutani, S., 2003. Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells. Cancer Res. 63, 2278-2283.
    • (2003) Cancer Res. , vol.63 , pp. 2278-2283
    • Kajiyama, H.1    Kikkawa, F.2    Khin, E.3    Shibata, K.4    Ino, K.5    Mizutani, S.6
  • 33
    • 0141484615 scopus 로고    scopus 로고
    • A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
    • Kamal, A., Thao, L., Sensintaffar, J., et al., 2003. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425, 407-410.
    • (2003) Nature , vol.425 , pp. 407-410
    • Kamal, A.1    Thao, L.2    Sensintaffar, J.3
  • 34
    • 0037087585 scopus 로고    scopus 로고
    • Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors
    • Kuenen, B.C., Rosen, L., Smit, E.F., et al., 2002. Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. J. Clin. Oncol. 20, 1657-1667.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1657-1667
    • Kuenen, B.C.1    Rosen, L.2    Smit, E.F.3
  • 35
    • 85030882666 scopus 로고    scopus 로고
    • Targeting BRAF by siRNA in human melanoma
    • abstract A111
    • Liang, Y.Z., Gawad, C., Azorsa, D., et al., 2003. Targeting BRAF by siRNA in human melanoma. Clin. Cancer Res. 9 (16 Suppl.), 6096S (abstract A111).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Liang, Y.Z.1    Gawad, C.2    Azorsa, D.3
  • 36
    • 3042825803 scopus 로고    scopus 로고
    • Skin toxicity is not a clinically prognostic marker for tumor response to gefitinib (Iressa, ZD1839) in pre-treated patients with advanced non-small cell lung cancer
    • abstract A70
    • Lynch, T., Ranson, M., Herbst, R., et al., 2003. Skin toxicity is not a clinically prognostic marker for tumor response to gefitinib (Iressa, ZD1839) in pre-treated patients with advanced non-small cell lung cancer. Clin. Cancer Res. 9 (16 Suppl.), 6086S (abstract A70).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Lynch, T.1    Ranson, M.2    Herbst, R.3
  • 37
    • 0242490063 scopus 로고    scopus 로고
    • Abrogation of E-cadherin-mediated adhesion induces tumor cell invasion in human skin-like organotypic culture
    • Margulis, A., Fusenig, N., Hashimoto, K., Hanakawa, Y., Garlick, J.A., 2003. Abrogation of E-cadherin-mediated adhesion induces tumor cell invasion in human skin-like organotypic culture. J. Investig. Dermatol. 121, 1182-1190.
    • (2003) J. Investig. Dermatol. , vol.121 , pp. 1182-1190
    • Margulis, A.1    Fusenig, N.2    Hashimoto, K.3    Hanakawa, Y.4    Garlick, J.A.5
  • 38
    • 85030883042 scopus 로고    scopus 로고
    • Mechanism of action of pre-operative trastuzumab in patients with primary operable breast tumors overexpressing HER2
    • abstract B270
    • Menard, S., Gennari, R., Fagnoni, F., et al., 2003. Mechanism of action of pre-operative trastuzumab in patients with primary operable breast tumors overexpressing HER2. Clin. Cancer Res. 9 (16 Suppl.), 6203S (abstract B270).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Menard, S.1    Gennari, R.2    Fagnoni, F.3
  • 39
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn, J., Baselga, J., 2003. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 21, 2787-2799.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 40
    • 0141520276 scopus 로고    scopus 로고
    • Drug resistance and the microenvironment: Nature and nurture
    • Morin, P.J., 2003. Drug resistance and the microenvironment: nature and nurture. Drug Resist. Update 6, 169-172.
    • (2003) Drug Resist. Update , vol.6 , pp. 169-172
    • Morin, P.J.1
  • 41
    • 0344626926 scopus 로고    scopus 로고
    • Structural basis for the autoinhibition of c-Abl tyrosine kinase
    • Nagar, B., Hantschel, O., Young, M.A., et al., 2003. Structural basis for the autoinhibition of c-Abl tyrosine kinase. Cell 112, 859-871.
    • (2003) Cell , vol.112 , pp. 859-871
    • Nagar, B.1    Hantschel, O.2    Young, M.A.3
  • 43
    • 10744226821 scopus 로고    scopus 로고
    • Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays
    • Nishizuka, S., Charboneau, L., Young, L., 2003. Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays. Proc. Natl. Acad. Sci. U.S.A. 100, 14229-14234.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 14229-14234
    • Nishizuka, S.1    Charboneau, L.2    Young, L.3
  • 44
    • 0345359585 scopus 로고    scopus 로고
    • An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukaemia patients
    • O'Farrell, A.-M., Foran, J.M., Fiedler, W., 2003. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukaemia patients. Clin. Cancer Res. 9, 5465-5476.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5465-5476
    • O'Farrell, A.-M.1    Foran, J.M.2    Fiedler, W.3
  • 46
    • 2942563441 scopus 로고    scopus 로고
    • Phase II study of BAY 43-9006 using the randomized discontinuation design in patients with advanced refractory cancer
    • abstract C254
    • Ratain, M.J., Stadler, W., Smith, M., et al., 2003. Phase II study of BAY 43-9006 using the randomized discontinuation design in patients with advanced refractory cancer. Clin. Cancer Res. 9 (16 Suppl.), 6265S-6266S (abstract C254).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Ratain, M.J.1    Stadler, W.2    Smith, M.3
  • 47
    • 24844463592 scopus 로고    scopus 로고
    • Receptor-based targeting strategy for bombesin receptor expressing cancers
    • abstract B236
    • Safavy, A., McChesnet, J.D., Ainsworth, S.K., Helson, L., 2003. Receptor-based targeting strategy for bombesin receptor expressing cancers. Clin. Cancer Res. 9 (16 Suppl.), 6194S (abstract B236).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Safavy, A.1    McChesnet, J.D.2    Ainsworth, S.K.3    Helson, L.4
  • 48
    • 0036462583 scopus 로고    scopus 로고
    • EGF receptor targeting in therapy-resistant human tumors
    • Schmidt, M., Lichtner, R.B., 2002. EGF receptor targeting in therapy-resistant human tumors. Drug Resist. Update 5, 11-18.
    • (2002) Drug Resist. Update , vol.5 , pp. 11-18
    • Schmidt, M.1    Lichtner, R.B.2
  • 50
    • 85030887892 scopus 로고    scopus 로고
    • Cellular metabolism of Poly-L-glutamic acid-palitaxel (Xyotax) is mediated in part by lysosomal cathepsin B
    • abstract C237
    • Shaffer, S.A., Baker Lee, C., Lai, M.S., et al., 2003. Cellular metabolism of Poly-L-glutamic acid-palitaxel (Xyotax) is mediated in part by lysosomal cathepsin B. Clin. Cancer Res. 9 (16 Suppl.), 6261S (abstract C237).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Shaffer, S.A.1    Baker Lee, C.2    Lai, M.S.3
  • 51
    • 0141484480 scopus 로고    scopus 로고
    • Remodeling of the extracellular matrix thruogh overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells
    • Sherman-Baust, C.A., Weeraratna, A.T., Rangel, L.B.A., et al., 2003. Remodeling of the extracellular matrix thruogh overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells. Cancer Cell 3, 377-386.
    • (2003) Cancer Cell , vol.3 , pp. 377-386
    • Sherman-Baust, C.A.1    Weeraratna, A.T.2    Rangel, L.B.A.3
  • 52
    • 2942619658 scopus 로고    scopus 로고
    • Pulsatile administration of the EGFR receptor inhibitor gefitinib (Iressa, ZD1839) is significantly more effective than continuous dosing for sensitizing tumors to Taxol
    • abstract A83
    • Solit, D.B., She, Y., Moasser, M., et al., 2003. Pulsatile administration of the EGFR receptor inhibitor gefitinib (Iressa, ZD1839) is significantly more effective than continuous dosing for sensitizing tumors to Taxol. Clin. Cancer Res. 9 (16 Suppl.), 6089S (abstract A83).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Solit, D.B.1    She, Y.2    Moasser, M.3
  • 53
    • 85030887664 scopus 로고    scopus 로고
    • Tumor-stroma interaction: Positive feedback regulation of EMMPRIN expression and MMP-dependent generation of soluble EMMPRIN
    • abstract B194
    • Tang, Y., Kesavan, P., Nakada, M.T., Yan, L., 2003. Tumor-stroma interaction: positive feedback regulation of EMMPRIN expression and MMP-dependent generation of soluble EMMPRIN. Clin. Cancer Res. 9 (16 Suppl.), 6184S (abstract B194).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Tang, Y.1    Kesavan, P.2    Nakada, M.T.3    Yan, L.4
  • 54
    • 85030874465 scopus 로고    scopus 로고
    • Preclinical activity of AEE788, a potent new inhibitor of the ErbB and VEGF receptor kinases. In vivo profile of AEE788
    • abstract A87
    • Traxler, P., Allegrini, P.R., Brandt, R., 2003. Preclinical activity of AEE788, a potent new inhibitor of the ErbB and VEGF receptor kinases. In vivo profile of AEE788. Clin. Cancer Res. 9 (16 Suppl.), 6090S (abstract A87).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Traxler, P.1    Allegrini, P.R.2    Brandt, R.3
  • 55
    • 0038037108 scopus 로고    scopus 로고
    • Role of Jun and Jun kinase in resistance of cancer cells to therapy
    • Vasilevskaya, I., O'Dwyer, P.J., 2003. Role of Jun and Jun kinase in resistance of cancer cells to therapy. Drug Resist. Update 6, 147-156.
    • (2003) Drug Resist. Update , vol.6 , pp. 147-156
    • Vasilevskaya, I.1    O'Dwyer, P.J.2
  • 56
    • 0345600892 scopus 로고    scopus 로고
    • Resistance to imatinib (Glivec): Update on clinical mechanisms
    • Weisberg, E., Griffin, J.D., 2003. Resistance to imatinib (Glivec): update on clinical mechanisms. Drug Resist. Update 6, 231-238.
    • (2003) Drug Resist. Update , vol.6 , pp. 231-238
    • Weisberg, E.1    Griffin, J.D.2
  • 57
    • 0036968347 scopus 로고    scopus 로고
    • Activation of the PI3K/Akt pathway and chemotherapeutic resistance
    • West, K.A., Castillo, S.S., Dennis, P.A., 2002. Activation of the PI3K/Akt pathway and chemotherapeutic resistance. Drug Resist. Update 5, 234-258.
    • (2002) Drug Resist. Update , vol.5 , pp. 234-258
    • West, K.A.1    Castillo, S.S.2    Dennis, P.A.3
  • 58
    • 16244423389 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum anti-tumor activity and targets raf/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • abstract A78
    • Wilhelm, S., Carter, C., Tang, L., et al., 2003. BAY 43-9006 exhibits broad spectrum anti-tumor activity and targets raf/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Clin. Cancer Res. 9 (16 Suppl.), 6088S (abstract A78).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.16 SUPPL.
    • Wilhelm, S.1    Carter, C.2    Tang, L.3
  • 59
    • 0345707575 scopus 로고    scopus 로고
    • The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of Akt in ErbB2 overexpressing breast cancer cells
    • Xu, W., Yuan, X., Jung, Y.J., 2003. The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of Akt in ErbB2 overexpressing breast cancer cells. Cancer Res. 63, 7777-7784.
    • (2003) Cancer Res. , vol.63 , pp. 7777-7784
    • Xu, W.1    Yuan, X.2    Jung, Y.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.