Effect of cyclosporin A on human gingival fibroblast collagen turnover in relation to the development of gingival overgrowth: An in vitro study

Biomedicine and Pharmacotherapy

Volumn 58, Issue 4, 2004, Pages 231-238

  Gagliano, Nicoletta ^a   Moscheni, Claudia ^a   Dellavia, Claudia ^a   Torri, Carlo ^a   Stabellini, Giordano ^a   Ferrario, Virgilio F ^a   Gioia, Magda ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

COL; collagen; Collagen turnover; Cyclosporin A; ECM; extracellular matrix; Gingival overgrowth; Matrix metalloproteinases; matrix metalloproteinases; MMP; TIMP; tissue inhibitor of metalloproteinases

Indexed keywords

COLLAGEN TYPE 1; CYCLOSPORIN A; GELATINASE A; INTERSTITIAL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FIBROBLAST; GINGIVA OVERGROWTH; HUMAN; HUMAN CELL; MASTICATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPEECH;

CELLS, CULTURED; COLLAGEN TYPE I; CYCLOSPORINE; FIBROBLASTS; GINGIVA; GINGIVAL OVERGROWTH; HUMANS; IMMUNOBLOTTING; IMMUNOSUPPRESSIVE AGENTS; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 2; MICROSCOPY, ELECTRON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 2942624529     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2003.12.011     Document Type: Article

References (45)

1. Angel P., Baumann I., Stein B., Delius H., Rahmsdorf H.J., Herrlich P. 12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5′-flanking region. Mol Cell Biol. 7:1987;2256-2266
2. Arora P.D., Silvestri L., Ganss B., Sodek J., McCulloch C.A. Mechanism of cyclosporin-induced inhibition of intracellular collagen degradation. J Biol Chem. 276:2001;14100-14109
3. Birkedal-Hansen H. Role of matrix metalloproteinases in human periodontal diseases. J Periodontol. 64:1993;474-484
4. Bolzani G., Della Coletta R., Martelli Junior H., De Almeida O.P., Graner E. Cyclosporin A inhibits production and activity of matrix metalloproteinases by gingival fibroblasts. J Periodontal Res. 35:2000;51-58
5. Border W.A., Ruoslahti E. Transforming growth factor-β in disease: the dark side of tissue repair. J Clin Invest. 90:1992;1-7
6. Brew K., Dinakarpandian D., Nagase H. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta. 1477:2001;267-283
7. Brinckerhoff C.E., Plucinska I.M., Sheldon L.A., O'Connor G.T. Half-life of synovial cell collagenase mRNA is modulated by phorbol myristate acetate but not by all-trans-retinoic acid or dexamethasone. Biochemistry. 25:1986;6378-6384
8. Chang S.H., Lim C.S., Low T.S., Chong H.T., Tan S.Y. Cyclosporine- associated encephalopathy: a case report and literature review. Transplant Proc. 33:2001;3700-3701
9. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159
10. Dongari A., McDonnell H.T., Langlais R.P. Drug-induced gingival overgrowth. Oral Surg Oral Med Oral Pathol. 76:1993;543-548
11. Edwards D.R., Murphy G., Reynolds J.J., Whitham S.E., Docherty A.J., Angel P., et al. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J. 6:1987;1899-1904
12. Esposito C., Fornoni A., Cornacchia F., Bellotti N., Fasoli G., Foschi A., et al. Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures. Kidney Int. 58:2000;123-130
13. Faulds D., Goa K.L., Benfield P. Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs. 45:1993;953-1040
14. Fu E., Nieh S., Chang H.L., Wang S.L. Dose-dependent gingival overgrowth induced by cyclosporin in rats. J Periodontol. 66:1995;594-598
15. Gagliano N., Arosio B., Grizzi F., Masson S., Tagliabue J., Dioguardi N., et al. Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat. Mech Ageing Dev. 123:2002;413-425
16. Galan A.I., Fernandez E., Moran D., Munoz M.E., Jimenez R. Cyclosporine A hepatotoxicity: effect of prolonged treatment with cyclosporine on biliary lipid secretion in the rat. Clin Exp Pharmacol Physiol. 22:1995;260-265
17. Hassell T.M., Hefti A.F. Drug-induced gingival overgrowth: old problem, new problem. Crit Rev Oral Biol Med. 2:1991;103-137
18. Herron G.S., Banda M.J., Clark E.J., Gavrilovic J., Werb Z. Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. J Biol Chem. 261:1986;2814-2818
19. Hyland P.L., Traynor P.S., Myrillas T.T., Marley J.J., Linden G.J., Winter P., et al. The effects of cyclosporin on the collagenolytic activity of gingival fibroblasts. J Periodontol. 74:2003;437-445
20. Ignotz R.A., Massague J. Transforming growth factor-beta1 stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem. 261:1986;4337-4345
21. James J.A., Irwin C.R., Linden G.J. Gingival fibroblast response to cyclosporin A and transforming growth factor β1. J Periodontal Res. 33:1998;40-48
22. Kataoka M., Shimizu Y., Kunikiyo K., Asahara Y., Yamashita K., Ninomiya M., et al. Cyclosporin A decreases the degradation of type I collagen in rat gingival overgrowth. J Cell Physiol. 182:2000;351-358
23. Kleiner D.E., Stetler-Stevenson W.G. Quantitative zymography: detection of picogram quantities of gelatinases. Anal Biochem. 218:1994;325-329
24. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685
25. Marshall R.I., Bartold P.M. Medication induced gingival overgrowth. Oral Dis. 4:1998;130-151
26. Martins R.C., Werneck C.C., Rocha L.A., Feres-Filho E.J., Silva L.C. Molecular size distribution analysis of human gingival glycosaminoglycans in cyclosporin- and nifedipine-induced overgrowths. J Periodontal Res. 38:2003;182-189
27. Newell J., Irwin C.R. Comparative effects of cyclosporin on glycosaminoglycan synthesis by gingival fibroblasts. J Periodontol. 68:1997;443-447
28. Overall C.M., Wrana J.L., Sudek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem. 264:1989;1860-1869
29. Phipps R.P., Borrello M.A., Blieden T.M. Fibroblast heterogeneity in the periodontium and other tissues. J Periodontal Res. 32:1997;159-165
30. Rocha L.A., Martins R.C., Werneck C.C., Feres-Filho E.J., Silva L.C. Human gingival glycosaminoglycans in cyclosporin-induced overgrowth. J Periodontal Res. 35:2000;158-164
31. Sakai T., Gross J. Some properties of the products of reaction of tadpole collagenase with collagen. Biochemistry. 6:1967;518-528
32. Schincaglia G.P., Forniti F., Cavallini R., Piva R., Calura G., del Senno L. Cyclosporin-A increases type I procollagen production and mRNA level in human gingival fibroblasts in vitro. J Oral Pathol Med. 21:1992;181-185
33. Seymour R.A., Jacobs D.J. Cyclosporin and the gingival tissues. J Clin Periodontol. 19:1992;1-11
34. Sporn M.B., Roberts A.B., Wakefield L.M., de Combrugghe B. Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol. 105:1987;1039-1045
35. Sporn M.B., Roberts A.B. The transforming growth factor-βs: past, present and future. Ann NY Acad Sci. 593:1990;1-6
36. Stabellini G., Carinci F., Bedani P.L., et al. Cyclosporin A and transforming growth factor β modify the pattern of extracellular glycosaminoglycans without causing cytoskeletal changes in human gingival fibroblasts. Transplantation. 73:2002;1676-1679
37. Stricklin G.P., Jeffrey J.J., Roswit W.T., Eisen A.Z. Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin. Biochemistry. 22:1983;61-68
38. Sugano N., Ito K., Murai S. Cyclosporin A inhibits collagenase gene expression via AP-1 and JNK suppression in human gingival fibroblasts. J Periodontal Res. 33:1998;448-452
39. Textor S.C., Canzanello V.J., Taler S.J., Wilson D.J., Schwartz L.L., Augustine J.E., Raymer J.M., Romero J.C., Wiesner R.H., Krom R.A. Cyclosporine-induced hypertension after transplantation. Mayo Clinic Proc. 69:1994;1182-1193
40. Thomason J.M., Sloan P., Seymour R.A. Immunolocalization of collagenase (MMP-1) and stromelysin (MMP-3) in the gingival tissues of organ transplant patients medicated with cyclosporin. J Clin Periodontol. 25:1998;554-560
41. Tipton D.A., Stricklin G.P., Dabbous M.K. Fibroblast heterogeneity in collagenolytic response to cyclosporine. J Cell Biochem. 46:1991;152-165
42. Tuter G., Serdar M.A., Yalim M., Gurhan I.S., Balos K. Evaluation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 levels in gingival fibroblasts of cyclosporin A-treated patients. J Periodontol. 73:2002;1273-1278
43. Willershausen-Zonnchen B., Lemmen C., Schumacher U. Influence of cyclosporine A on growth and extracellular matrix synthesis of human fibroblasts. J Cell Physiol. 152:1992;397-402
44. Woessner J.F. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 5:1991;2145-2154
45. Woolfson R.G., Neild G.H. Cyclosporin nephrotoxicity following cardiac transplantation. Nephrol Dial Transplant. 12:1997;2054-2056