p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth

Molecular Cancer

Volumn 2, Issue , 2003, Pages

  Malicet, Cédric ^a   Lesavre, Nathalie ^a   Vasseur, Sophie ^a   Iovanna, Juan L ^a  

^a INSERM   (France)

Author keywords

JNK; p38; p8; Pancreatic cancer; Ras; TGF 1

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; COMPLEMENTARY RNA; HEAT SHOCK PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN P8; RAF PROTEIN; RAS PROTEIN; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; ENZYME INHIBITOR; GROWTH INHIBITOR; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; NITRILE; P8 PROTEIN, HUMAN; PYRIDINE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA; TUMOR PROTEIN;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETROVIRUS INFECTION; UPREGULATION; CELL PROLIFERATION; CHEMISTRY; CULTURE MEDIUM; DRUG ANTAGONISM; DRUG EFFECT; GENE VECTOR; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; RETROVIRUS; TUMOR CELL LINE;

UNIDENTIFIED RETROVIRUS;

ANTHRACENES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BUTADIENES; CELL LINE, TUMOR; CELL PROLIFERATION; CULTURE MEDIA; CULTURE MEDIA, SERUM-FREE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENETIC VECTORS; GROWTH INHIBITORS; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; NITRILES; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-RAF; PYRIDINES; RAS PROTEINS; RETROVIRIDAE; RNA, ANTISENSE; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 2942617091     PISSN: 14764598     EISSN: None     Source Type: Journal    
DOI: 10.1186/1476-4598-2-37     Document Type: Article

References (33)

1. Mallo GV, Fiedler F, Calvo EL, Ortiz EM, Vasseur S, Keim V, Morisset J and Iovanna JL: Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth. J Biol Chem 1997, 272:32360-32369.
2. Jiang YF, Vaccaro MI, Fiedler F, Calvo EL and Iovanna JL: Lipopolysaccharides induce p8 mRNA expression in vivo and in vitro. Biochem Biophys Res Commun 1999, 260:686-690.
3. Garcia-Montero A, Vasseur S, Mallo GV, Soubeyran P, Dagorn JC and Iovanna JL: Expression of the stress-induced p8 mRNA is transiently activated after culture medium change. Eur J Cell Biol 2001, 80:720-725.
4. Vasseur S, Mallo GV, Fiedler F, Bodeker H, Canepa E, Moreno S and Iovanna JL: Cloning and expression of the human p8, a nuclear protein with mitogenic activity. Eur J Biochem 1999, 259:670-675.
5. Vasseur S, Mallo GV, Garcia-Montero A, Ortiz EM, Fiedler F, Canepa E, Moreno S and Iovanna JL: Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter. Biochem J 1999, 343:377-383.
6. Igarashi T, Kuroda H, Takahashi S and Asashima M: Cloning and characterization of the Xenopus laevis p8 gene. Develop Growth Differ 2001, 43:693-698.
7. Bustin M and Reeves R: High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function. Prog Nucleic Acids Res Mol Biol 1996, 54:35-100.
8. Encinar JA, Mallo GV, Mizyrycki C, Giono L, Gonzalez-Ros JM, Rico M, Canepa E, Moreno S, Neira JL and Iovanna JL: Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation. J Biol Chem 2001, 276:2742-2751.
9. Hoffmeister A, Ropolo A, Vasseur S, Mallo GV, Bodeker H, Ritz-Laser B, Dressler GR, Vaccaro MI, Dagorn JC, Moreno S and Iovanna JL: The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter. J Biol Chem 2002, 277:22314-22319.
10. Garcia-Montero AC, Vasseur S, Giono LE, Canepa E, Moreno S, Dagorn JC and Iovanna JL: Transforming growth factor beta-1 enhances Smad transcriptional activity through activation of p8 gene expression. Biochem J 2001, 357:249-253.
11. Vasseur S, Hoffmeister A, Garcia-Montero A, Mallo GV, Feil R, Kuhbandner S, Dagorn JC and Iovanna JL: p8-deficient fibroblasts growth more rapidly and are more resistant to the apoptosis induced by adriamycin. Oncogene 2002, 21:1685-1694.
12. Bratland A, Risberg K, Maelandsmo GM, Gutzkow KB, Olsen OE, Moghaddam A, Wang MY, Hansen CM, Blomhoff HK, Berg JP, Fodstad O and Ree AH: Expression of a novel factor, com1, is regulated by 1,25-dihydroxyvitamin D3 in breast cancer cells. Cancer Res 2000, 60:5578-55783.
13. Goruppi S, Bonventre JV and Kyriakis JM: Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy. EMBO J 2002, 21:5427-5436.
14. Quirk CC, Seachrist DD and Nilson JH: Embryonic expression of the luteinizing hormone beta gene appears to be coupled to the transient appearance of p8, a high mobility group-related transcription factor. J Biol Chem 2003, 278:1680-1685.
15. Zinke I, Schutz CS, Katzenberger JD, Bauer M and Pankratz MJ: Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. EMBO J 2002, 21:6162-6173.
16. Vasseur S, Hoffmeister A, Garcia S, Bagnis C, Dagorn JC and Iovanna JL: p8 is critical for tumour development induced by rasV12 mutated protein and E1A oncogene. EMBO Rep 2002, 3:165-170.
17. Ree AH, Tvermyr M, Engebraaten O, Rooman M, Rosok O, Hovig E, Meza-Zepeda LA, Bruland OS and Fodstad O: Expression of a novel factor in human breast cancer cells with metastatic potential. Cancer Res 1999, 59:4675-4680.
18. Aoki K, Yoshida T, Sugimura T and Terada M: Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. Cancer Res 1995, 55:3810-3816.
19. Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, Gress T, Bassi C, Kloppel G, Kalthoff H, Ungefroren H, Lohr M and Scarpa A: Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch 2001, 439:798-802.
20. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N and Perucho M: Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988, 53:549-554.
21. Davies SP, Reddy H, Caivano M and Cohen P: Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000, 351:95-105.
22. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, Bhagwat SS, Manning AM and Anderson DW: SP600125 an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 0125, 98:13681-13686.
23. Ding XZ and Adrian TE: MEK/ERK-mediated proliferation is negatively regulated by P38 map kinase in the human pancreatic cancer cell line, PANC-1. Biochem Biophys Res Commun 2001, 282:447-453.
24. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR and Landvatter SW: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994, 372:739-746.
25. Takekawa M, Tatebayashi K, Itoh F, Adachi M, Imai K and Saito H: Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta. EMBO J 2002, 21:6473-6482.
26. Poston GJ, Gillespie J and Guillou PJ: Biology of pancreatic cancer. Gut 1991, 32:800-812.
27. Dergham ST, Dugan MC, Arlauskas P, Du W, Vaitkevicius VK, Crissman JD and Sarkar FH: Relationship of family cancer history to the expression of p53, p21WAF, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma. Int J Pancreatol 1997, 21:225-234.
28. Rozenblum E, Schutte M, Goggins M, Hahn SA, Panzer S, Zahurak M, Goodman SN, Sohn TA, Hruban RH, Yeo CJ and Kern SE: Tumor suppressive pathways in pancreatic cancer. Cancer Res 1997, 57:1731-1734.
29. Huang L, Goodrow TL, Zhang SY, Klein-Szanto AJ, Chang H and Ruggeri BA: Deletion and mutational analyses of the p16/MTS-1 tumor-suppressor gene in human ductal pancreatic cancer reveals a high frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas. Cancer Res 1996, 56:1137-1141.
30. Simon B, Bartsch D, Barth P, Prasnikar N, Munch K, Blum A, Arnold R and Goke B: Frequent abnormalities of the putative suppressor gene FHIT at 3p14.2 in pancreatic carcinoma cell lines. Cancer Res 1998, 58:1583-1587.
31. Dergham ST, Dugan MC, Kucway R, Du W, Kamarauskiene DS, Vaitkevicius VK, Crissman JD and Sarkar FH: Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma. Int J Pancreatol 1997, 21:127-143.
32. Seed B and Sheen JY: A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene 1988, 67:271-277.
33. Sambrook J, Fritsch EF and Maniatis T: Molecular Cloning: A Laboratory Manual. 2nd edition. Cold Spring Harbor Lab. Press, Plainview, NY; 1989.