High-throughput pharmacokinetics screen of VLA-4 antagonists by LC/MS/MS coupled with automated solid-phase extraction sample preparation

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 4, 2004, Pages 867-877

  Tong, Xinchun S ^a   Wang, Junying ^a   Zheng, Song ^a   Pivnichny, James V ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Automation; High throughput; LC MS MS; SPE; VLA 4

Indexed keywords

ANTIINFLAMMATORY AGENT; UNCLASSIFIED DRUG; VERY LATE ACTIVATION 4 ANTAGONIST; VERY LATE ACTIVATION ANTIGEN 4;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; AUTOMATION; CONTROLLED STUDY; DILUTION; DRUG CLEARANCE; DRUG HALF LIFE; DRUG IDENTIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; INSTRUMENTATION; MALE; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; RAT; REACTION TIME; RELIABILITY; ROBOTICS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; INTEGRIN ALPHA4BETA1; MALE; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 2942610884     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2004.02.017     Document Type: Article

References (22)

1. Hagmann W.K., Durette P.L., Lanza T., Kevin N.J., de Laszlo S.E., Kopka I.E., Young D., Magriotis P.A., Li B., Lin L.S., Yang G., Kamenecka T., Chang L.L., Wilson J., MacCoss M., Mills S.G., Van Riper G., McCauley E., Egger L.A., Kidambi U., Lyons K., Vincent S., Stearns R., Colletti A., Teffera J., Tong X.S., Fenyk-Melody J., Owens K., Levorse D., Kim P., Schmidt J.A., Mumford R.A. Bioorg. Med. Chem. Lett. 11:2001;2709-2713
2. Yang G.X., Truong Q., Doherty G.A., Magriotis P.A., deLaszlo S.E., Li B., MacCoss M., Kidambi U., Egger L.A., McCauley E., Van Riper G., Mumford R.A., Schmidt J.A., Hagmann W.K. L.L. Chang. Bioorg. Med. Chem. Lett. 12:2002;1497-1500
3. Gutteridge C.E., de Laszlo S.E., McCauley E., Van Riper G., Mumford R.A., Kidambi U., Egger L.A., Tong X.S., Hagmann W.K. Bioorg. Med. Chem. Lett. 13:2003;885-890
4. Kopka I.E., Young D., Lin L., MacCoss M., Mills S.G., Van Riper G., McCauley E., Egger L., Kidambi U., Schmidt J.A., Lyons K., Stearns R., Vincent S., Colletti A., Wang Z., Tong X.S., Wang J., Zheng S., Owens K., Levorse D., Hagmann W.K., Mumford R.A. Bioorg. Med. Chem. Lett. 12:2002;2415-2418
5. Lin L.S., Kopka I., Mumford R.A., Kamenecka T., Lanza T. Jr., Magriotis P.A., Young D.N., de Laszlo S.E., McCauley E., Van Riper G., Kidambi U., Egger L.A., Lyons K., Vincent S., Tong X.S., Schmidt J.A., MacCoss M., Hagmann W.K. Bioorg. Med. Chem. Lett. 12:2002;611-614
6. Heath T.G., Scott D.O. J. Am. Mass Spectrom. 8:1997;371-379
7. Olah T.V., McLoughlin D.A., Gilbert J.D. Rapid Commun. Mass Spectrom. 11:1997;17-23
8. Tong X.S., Ita I.E., Wang J., Pivnichny J.V. J. Pharm. Biomed. Anal. 20:1999;773-784
9. Covey T.R., Lee E.D., Henion J.D. Anal. Chem. 58:1986;2453-2460
10. Henion J., Brewer E., Rule G. Anal. Chem. 70:1998;650A-656A
11. Rossi D.T. LC-GC. 17:1999;S4-S8
12. Smith G.A., Lloyd T.L. LC-GC. 16:1998;S22-S31
13. D.A. Wells, LC-GC (1999) 600-610.
14. Rule G., Henion J. J. Am. Soc. Mass Spectrum. 10:1999;1322-1327
15. Ke J., Yancey M., Zheng S., Lowes S., Henion J. J. Chromatogr. B. Biomed. Sci. Appl. 742:2000;369-380
16. Haky J.E., Young A.M. J. Liq. Chromatogr. 7:1984;675
17. Tong X.S., Wang J., Zheng S., Pivnichny J., Griffin P., Shen X., Donnelly M., Vakerich K., Nunes C., Fenyk-Melody J. Anal. Chem. 74:2002;6305-6313
18. Simpson H., Berthemy A., Buhrman D., Burton R., Newton J., Kealy M., wells D., Wu D. Rapid Commun. Mass Spectrom. 12:1998;75-82
19. Shou W.Z., Pelzer M., Addison T., Jiang X., Naidong W. J. Pharm. Biomed. Anal. 27:2002;143-152
20. Huang N.H., Kagel J.R., Rossi D.T. J. Pharm. Biomed. Anal. 19:1999;613-620
21. Peng S.X., Branch T.M., King S.L. Anal. Chem. 73:2001;708-714
22. Watt A.P., Morrison D., Locker K.L., Evans D.C. Anal. Chem. 72:2000;979-984