Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 17, 2002, Pages 2415-2418

  Kopka, Ihor E ^a   Lin, Linus S ^a   Mumford, Richard A ^a   Lanza Jr , Thomas ^a   Magriotis, Plato A ^a   Young, David ^a   DeLaszlo, Stephen E ^a   MacCoss, Malcolm ^a   Mills, Sander G ^a   Van Riper, Gail ^a   McCauley, Ermengilda ^a   Lyons, Kathryn ^a   Vincent, Stella ^a   Egger, Linda A ^a   Kidambi, Usha ^a   Stearns, Ralph ^a   Colletti, Adria ^a   Teffera, Yohannes ^a   Tong, Sharon ^a   Owens, Karen ^a   Levorse, Dorothy ^a   Schmidt, John A ^a   Hagmann, William K ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE DERIVATIVE; BETA1 INTEGRIN; BIO 1211; PLASMA PROTEIN; PROPIONIC ACID DERIVATIVE; PROTEIN INHIBITOR; TR 14035; UNCLASSIFIED DRUG; ALANINE; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; NONHUMAN; RAT; RHESUS MONKEY; BIOAVAILABILITY; DRUG ANTAGONISM; HUMAN; IC 50; LEUKEMIA CELL LINE; METABOLIC CLEARANCE RATE; METABOLISM; ORAL DRUG ADMINISTRATION; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADMINISTRATION, ORAL; ALANINE; BIOLOGICAL AVAILABILITY; HUMANS; INHIBITORY CONCENTRATION 50; INTEGRIN ALPHA4BETA1; JURKAT CELLS; METABOLIC CLEARANCE RATE; PROPIONIC ACIDS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR CELL ADHESION MOLECULE-1;

EID: 18544381846     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00460-2     Document Type: Article

References (12)