Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis

International Immunopharmacology

Volumn 4, Issue 7, 2004, Pages 963-973

  Kim, Kanp Sung ^a   Choi, Yoo Haeng ^a   Kim, Kyung Ho ^a   Lee, Young Choon ^b   Kim, Cheorl Ho ^a   Moon, Sang Ho ^c   Kang, Seung Goo ^d   Park, Young Guk ^d  

^a Dongguk University   (South Korea)

^b Dong A University   (South Korea)

^c Handong University   (South Korea)

^d Kyung Hee University   (South Korea)

Author keywords

Apoptosis; Chondrocytes; Deer antler aqua acupunture; Growth plate; Inorganic phosphate (Pi); NaPi 2; Pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong) Type II collagen induced arthritis; Rheumatoid arthritis

Indexed keywords

DEER ANTLER AQUA ACUPUNCTURE EXTRACT; DIHYDROOROTATE DEHYDROGENASE; FOSCARNET; IMMUNOSUPPRESSIVE AGENT; UNCLASSIFIED DRUG;

ACUPUNCTURE; ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE DESTRUCTION; CARTILAGE CELL; CELL DEATH; CELL ISOLATION; CELL PROTECTION; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME INHIBITION; EXPERIMENTAL MODEL; FEMALE; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SECONDARY PREVENTION; TRADITIONAL MEDICINE; WEIGHT REDUCTION;

ACUPUNCTURE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTLERS; APOPTOSIS; ARTHRITIS, EXPERIMENTAL; CELL LINE; CELL SURVIVAL; CHONDROCYTES; COLLAGEN; DEER; FEMALE; FOSCARNET; IMMUNOSUPPRESSIVE AGENTS; IN SITU NICK-END LABELING; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS; SYMPORTERS; TISSUE EXTRACTS; WATER;

EID: 2942609095     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2004.04.010     Document Type: Article

References (36)

1. Wang B.-X., Zhao X.-H., Yang X.-W., Kaneko S., Hattori M., Namba T., et al. Inhibition of lipid peroxidation by deer antler (Rokujo) extract in vivo and in vitro. J. Med. Pharm. Soc. Wakan-yaku. 5:1988;123-128
2. Wang B.-X., Zhao X.-H., Qi S.-B., Kaneko S., Hattori M., Namba T., et al. Effects of repeated administration of deer antler (Rokujo) extract on biochemical changes related to aging in senescence-accelerated mice. Chem. Pharm. Bull. 36:1988;2587-2592
3. Testa V., Capasso F., Muffulli N., Sgambato A., Ames P.R.J. Proteases and antiproteases in cartilage homeostasis. Clin. Orthop. Relat. Res. 308:1994;79-84
4. Einhorn T.A., Majeska R.J. Neutral proteases in regenerating bone. Clin. Orthop. 262:1991;286-297
5. Trentham D.E. Collagen arthritis as a relevant model for rheumatoid arthritis. Arthritis Rheum. 25:1982;911-916
6. Kroemer G., Petit P., Zamzami N., Vayssiere J.L., Mignotte B. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1287
7. Gibson G., Lin D.L., Roque M. Apoptosis of terminally differentiated chondrocytes in culture. Exp. Cell Res. 233:1997;372-382
8. Shapiro I.M., Boyde A. Microdissection: elemental analysis of the mineralizing growth cartilage of the normal and rachitic chick. Metab. Bone Dis. Relat. Res. 5:1984;317-326
9. Masfield K., Teixeria C.C., Adams C.S., Shapiro I.M. Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism. Bone. 28:2001;1-8
10. Jaffee B.D., Jones E.A., Loveless S.E., Chen S.F. The unique immunosuppressive activity of brequinar sodium. Transplant. Proc. 25:1993;19-22
11. Xu X., Williams J.W., Shen J., Gong H., Yin D.P., Blinder L. In vitro and in vivo mechanism of action of the antiproliferative and immunosuppressive agent, brequinar sodium. J. Immunol. 160:1998;846-853
12. Cherwinski H.M., Cohen R.G., Cheung P., Webster D.J., Xu Y.Z., Caufield J.P. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimide biosynthesis. J. Pharmacol. Exp. Ther. 275:1995;1043-1049
13. Kim Y.K., Kim K.S., Chung K.H., Kim J.G., Kim K.S., Lee Y.C., et al. Inhibitory effects of deer antler aqua-acupuncture, the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe, on type II collagen-induced arthritis in rats. Int. Immunopharmacol. 3(7):2003;1001-1010
14. Boyan B.D., Schwartz Z., Swain L.D., Carnes D.L. Jr., Zislis T. Differential expression of phenotype by resting zone and growth region costochondral chondrocytes in vitro. Bone. 9:1988;185-194
15. Oshima O., Leboy P.S., McDonald S.A., Tuan R.S., Shapiro I.M. Developmental expression of genes in chick growth cartilage detected by in situ hybridization. Calcif. Tissue Int. 45:1989;182-192
16. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63
17. McGahon A.J., Martin S.J., Bissonnette R.P., Mahboubi A., Shi Y., Mogil R.J., et al. The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell. Biol. 46:1995;153-185
18. Van Veldhoven P.P., Mannaerts G.P. Inorganic and organic phosphate measurements in the nanomolar range. Anal. Biochem. 161:1987;45-48
19. Hom J.T., Gliszczynski V.L., Cole H.W., Bendele A.M. Interleukin 1-mediated acceleration of type II collagen-induced arthritis:effects of anti-inflammatory or anti-arthritic drugs. Agents Actions. 33:1991;300-309
20. Peters G.J., Laurensse E., Leyva A., Ponedo H.M. A sensitive, nonradiometric assay for dihydroorotic acid dehydrogenase using anion-exchange high-performance liquid chromatography. Anal. Biochem. 161:1987;32-38
21. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.I. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193:1951;265-275
22. Snedecor G.W., Cochran W.G. Statistical Methods. 6th ed. 1967;Iowa State University, Ames, IA
23. Suh J.S., Eun J.S., So J.N., Seo J.T., Jhon G.J. Phagocytic activity of ethyl alcohol fraction of deer antler in murine peritoneal macrophage. Biol. Pharm. Bull. 22:1999;932-935
24. 2+ mobilizing agents in rat pancreatic acinar cells. Bioorg. Med. Chem. Lett. 9:1999;59-64
25. Park H.S., Jhon G.J., Choi W.J. Deer antler extract selectively suppresses hyphal growth in dimorphic fungus, Candida albicans. J. Microbiol. Biotechnol. 8:1998;291-294
26. Min J., Lee Y.J., Kim Y.A., Park H.S., Han S.Y., Jhon G.J., et al. Lysophosphatidylcholine derived from deer antler extract suppresses hyphal transition in Candida albicans through MAP kinase pathway. Biochim. Biophys. Acta. 1531:2001;77-89
27. Jhon G.J., Park S.Y., Han S.Y., Lee S., Kim Y., Chang Y.S. Studies of the chemical structure of gangliosides in deer antler, Cervus nippon. Chem. Pharm. Bull. (Tokyo). 47(1):1999;123-127
28. Choi H.J., Chung T.W., Kang N.Y., Kim K.S., Lee Y.C., Kim C.H. Transcriptional regulation of the human GM3 synthase (hST3Gal V) gene during monocytic differentiation of HL-60 cells. FEBS Lett. 555(2):2003;204-208
29. Choi H.J., Chung T.W., Kang N.Y., Kim K.S., Lee Y.C., Kim C.H. Involvement of CREB in the transcriptional regulation of the human GM3 synthase (hST3Gal V) gene during megakaryocytoid differentiation of human leukemia K562 cells. Biochem. Biophys. Res. Commun. 313(1):2004;142-147
30. Plotkin L.I., Weinstein R.S., Parfitt A.M., Roberson P.K., Manolagas S.C., Bellido T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J. Clin. Invest. 104:1999;1363-1374
31. Greenfield E.M., Bi Y., Miyauchi A. Regulation of osteoclast activity. Life Sci. 65:1999;1087-1102
32. Svhkolemmer H.U., Milbert U., Zeitter D., Haun G., Wunschel M., Martlett R.R. Cell cycle regulation and inhibition of de novo pyridine biosynthesis by leflunomide. Inflamm. Res. 48:1999;S5115-S5116
33. Davis J.P., Cain G.A., Pitts W.J., Magolda R.L., Copeland R.A. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase. Biochemistry. 35:1996;1270-1273
34. Xu X., Blinder L., Shen J., Gong H., Finnegan A., Williams J.W. In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr mice. J. Immunol. 159:1997;167-174
35. Wahl G.M., Linke S.P., Paulson T.G., Huang L.C. Maintaining genetic stability through TP53 mediated checkpoint control. Cancer Surv. 29:1997;183-219
36. Linke S.P., Clarkin S.P., Di Leonardo A., Tsou A., Wahl G.M. A reversible, p53-dependent G0.G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10:1996;934-947