Cell cycle regulation and inhibition of de novo pyrimidine biosynthesis by leflunomide

Inflammation Research

Volumn 48, Issue SUPPL. 2, 1999, Pages

  Schorlemmer, H U ^a   Milbert, U ^b   Zeitter, D ^a   Haun, G ^b   Wunschel, M ^a   Bartlett, R R ^a  

^a Research Laboratories   (Germany)

^b Hoechst Marion Roussel   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROOROTATE DEHYDROGENASE; LEFLUNOMIDE; PYRIMIDINE;

CELL CULTURE; CELL CYCLE; CELL DEATH; CELL LEVEL; CONFERENCE PAPER; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKEMIA CELL LINE; PYRIMIDINE SYNTHESIS;

ANILINE COMPOUNDS; CELL CYCLE; HUMANS; HYDROXYBUTYRATES; IMMUNOSUPPRESSIVE AGENTS; ISOXAZOLES; JURKAT CELLS; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PYRIMIDINES;

EID: 0033378249     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (8)

1. Mladenovic V, Domljan Z, Rozman B, Jajic I, Mihajlovic D, Dordevic J, et al. Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Arthritis Rheum 1995; 38: 1595-603.
2. Rozman B. Clinical experience with leflunomide in rheumatoid arthritis. J Rheumatol 1998; 25: 27-32.
3. Silva HT, Morris RE. Leflunomide and malononitrilamides. Am J Med Sci 1997; 313: 289-301.
4. Fox RI. Mechanism of action of leflunomide in rheumatoid arthritis. J Rheumatol 1998; 25: 20-6.
5. Ruckemann K, Fairbanks L, Carrey E, Hawrylowiez C, Richards D, Kirschbaum B, et al. Leflunomide inhibits pyrimidine de novo synthesis in mitogen stimulated T-lymphocytes from healthy humans. J Biol Chem 1998; 273: 21682-91.
6. Cherwinski HM, McCarley D, Schatzman R, Devens B, Ransom JT. The immunosuppressant leflunomide inhibits lymphocyte progression through cell cycle by a novel mechanism. J Pharmacol Exp Ther 1995; 272: 460-8.
7. Williamson RA, Yea CM, Robinson PA, Curnock A, Gadher S, Hambleton AB, et al. Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound. J Biol Chem 1995; 270: 22367-472.
8. Milbert U, Bartlett RR, Haun G, Zeitter D, Wunschel M, Schorlemmer HU, et al. A new sensitive method of high performance liquid chromatography with detection of conductivity for the determination of dihydroorotic acid. Rheum Eur 1998; 27: S109.