Phosphate ions mediate chondrocyte apoptosis through a plasma membrane transporter mechanism

Bone

Volumn 28, Issue 1, 2001, Pages 1-8

  Mansfield, K ^a   Teixeira, C C ^a   Adams, C S ^a   Shapiro, I M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alendronate; Apoptosis; Chondrocytes; Glvr 1; Growth plate; Inorganic phosphate (Pi); NaPi 2

Indexed keywords

ALENDRONIC ACID; FOSCARNET; PHOSPHATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL MATURATION; CELL MEMBRANE TRANSPORT; CHICKEN; DRUG EFFECT; GROWTH PLATE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALENDRONATE; ANIMALS; ANTIVIRAL AGENTS; APOPTOSIS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; CHICK EMBRYO; CHONDROCYTES; FOSCARNET; GROWTH PLATE; IN SITU NICK-END LABELING; PHOSPHATES; RECEPTORS, VIRUS; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE II; SYMPORTERS;

EID: 0035143951     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(00)00409-9     Document Type: Article

References (29)

1. The mitochondrial membrane permeability transition induced by inorganic phosphate or inorganic arsenate. A comparative study
2. Association of collagenase and tissue inhibitor of metalloproteinases (TIMP) with hypertrophic cell enlargement in the growth plate
3. Mechanisms of action of the bisphosphonates
4. Apoptosis of terminally differentiated chondrocytes in culture
5. Regulation of osteoclast activity
6. Regulation of sodium-dependent phosphate transport in osteoclasts
7. End labeling studies of fragmented DNA in the avian growth plate; Evidence of apoptosis in terminally differentiated chondrocytes
8. Identification and characterization of a widely expressed phosphate transporter/retrovirus receptor family
9. The biochemistry of programmed cell death
10. Cellular mechanisms of acute and chronic adaptation of rat renal Pi transporter to alterations in dietary Pi
11. Expression cloning of human and rat renal cortex Na/Pi cotransport
12. Extracellular phosphate ions cause apoptosis of terminally differentiated epiphyseal chondrocytes
13. The end of the (cell) line; Methods for the study of apoptosis in vitro
14. Pi transport regulation by chicken growth plate chondrocytes
15. Rapid colorimetric assay for cellular growth and survival; Application to proliferation and cytotoxicity assays
16. Developmental expression of genes in chick growth cartilage detected by in situ hybridization
17. In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retrovirus receptor during bone development
18. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin
19. Programmed cell death and the control of cell survival
20. Adaptation of chondrocytes to low oxygen tension; Relationship between hypoxia and cellular metabolism
21. Chondrocyte death is linked to development of a mitochondrial membrane permeability transition in the growth plate
22. Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase
23. Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism
24. The role of crystals in osteoarthritis
25. Cytokine and apoptosis gene networks that control development and cancer
26. Microdissection; Elemental analysis of the mineralizing growth cartilage of the normal and rachitic chick
27. Inorganic and organic phosphate measurements in the nanomolar range
28. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo