Insertional-fusion of basic fibroblast growth factor endowed ribonuclease 1 with enhanced cytotoxicity by steric blockade of inhibitor interaction

FEBS Letters

Volumn 568, Issue 1-3, 2004, Pages 39-43

  Tada, Hiroko ^a   Onizuka, Masayuki ^a   Muraki, Kazuko ^a   Masuzawa, Wataru ^a   Futami, Junichiro ^a   Kosaka, Megumi ^a   Seno, Masaharu ^a   Yamada, Hidenori ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Basic fibroblast growth factor; bFGF, basic fibroblast growth factor; CL RNase1, 4 118 cross linked RNase1 mutant; Insertional fusion protein; Protein engineering; RFNs, insertional fusion proteins between hRNase1 and bFGF; Ribonuclease; Targeting

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; HYBRID PROTEIN; PANCREATIC RIBONUCLEASE; RECOMBINANT ENZYME;

ANIMAL CELL; ARTICLE; BINDING SITE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; GENE FUSION; GENE INSERTION SEQUENCE; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; STEREOSPECIFICITY;

ANIMALS; BASE SEQUENCE; CELL DIVISION; CELL LINE, TUMOR; DNA PRIMERS; ENZYME INHIBITORS; FIBROBLAST GROWTH FACTOR 2; HUMANS; MICE; MICE, INBRED BALB C; RECOMBINANT FUSION PROTEINS; RIBONUCLEASE, PANCREATIC;

EID: 2942598158     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.05.007     Document Type: Article

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