Nimbidin suppresses functions of macrophages and neutrophils: Relevance to its antiinflammatory mechanisms

Phytotherapy Research

Volumn 18, Issue 5, 2004, Pages 419-424

  Kaur, Gurpreet ^a   Alam, M Sarwar ^a   Athar, M ^a  

^a Department of Geography   (India)

Author keywords

Azadirachta indica; Macrophages; Neutrophil; Nimbidin

Indexed keywords

ANTIINFLAMMATORY AGENT; AZADIRACHTA INDICA EXTRACT; INTERLEUKIN 1; LIPOPOLYSACCHARIDE; NIMBIDIN; NITRIC OXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEGRANULATION; DRUG EFFECT; DRUG EXPOSURE; DRUG RESEARCH; DRUG SCREENING; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROPHAGE FUNCTION; MALE; MELIACEAE; NEUTROPHIL; NONHUMAN; PERITONEAL CAVITY; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PLANT SEED; RAT; RESPIRATORY BURST;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; AZADIRACHTA; CELL MIGRATION INHIBITION; DINOPROSTONE; DITERPENES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; NEUTROPHILS; NITRIC OXIDE; PHAGOCYTOSIS; PHYTOTHERAPY; PLANT OILS; RATS; RATS, WISTAR; RESPIRATORY BURST; SEEDS;

AZADIRACHTA INDICA; MELIACEAE;

EID: 2942590460     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1474     Document Type: Article

References (28)

1. Alving K, Weitzberg E, Lundberg JM. 1993. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 6: 1368-1370.
2. Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. 2002. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 82: 1336-1345.
3. Bourke E, Moynagh PN. 1999. Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B. J Immunol 163: 2113-2119.
4. Bozeman PM, Hoidal JR, Shepherd VL. 1988. Oxidant-mediated inhibition of ligand uptake by the macrophage mannose receptor. J Biol Chem 263: 1240-1247.
5. D'Acquisto F, Sautebin L, Iuvone T, Di Rosa M, Carnuccio R. 1998. Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor-kappa B activation in J774 macrophages. FEBS Lett 440: 76-80.
6. De Young LM, Kheifets JB, Ballaron SJ, Young JM. 1989. Edema and cell infiltration in the phorbol ester-treated mouse ear are temporally separate and can be differentially modulated by pharmacologic agents. Agents Actions 26: 335-341.
7. Escrig V, Ubeda A, Ferrandiz ML, et al. 1997. Variabilin: a dual inhibitor of human secretory and cytosolic phospholipase A2 with antiinflammatory activity. J Pharmacol Exp Ther 282: 123-131.
8. Fuhrman B, Oiknine J, Aviram M. 1994. Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. Atherosclerosis 111: 65-78.
9. Green LC, Wanger DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR 1981. Analysis of nitrate, nitrite, [15N]nitrate in biological fluids. Anal Biochem 126: 131-138.
10. Halliwell B, Zhao K, Whiteman M. 1999. Nitric oxide and peroxynitrite: the ugly, the uglier and the not so good: a personal view of recent controversies. Free Radic Res 31: 651-669.
11. Harris SG, Padilla J, Koumas L, Ray D, Phipps RP. 2002. Prostaglandins as modulators of immunity. Trends Immunol 23: 144-150.
12. Keisari Y, Pick E. 1981. Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages - induction by multiple nonphagocytic stimuli. Cell Immunol 62: 172-185.
13. Lefkowitz DL, Gelderman MP, Fuhrmann SR, et al. 1999. Neutrophilic myeloperoxidase-macrophage interactions perpetuate chronic inflammation associated with experimental arthritis. Clin Immunol 91: 145-155.
14. Li YM, Baviello G, Vlassara H, Mitsuhashi T. 1997. Glycation products in aged thioglycollate medium enhance the elicitation of peritoneal macrophages. J Immunol Methods 201: 183-188.
15. Liew FY, McInnes IB. 2002. The role of innate mediators in inflammatory response. Mol Immunol 38: 887-890.
16. Liu Q, Wang Y, Thorlacius H. 2000. Dexamethasone inhibits tumor necrosis factor-alpha-induced expression of macrophage inflammatory protein-2 and adhesion of neutrophils to endothelial cells. Biochem Biophys Res Commun 271: 364-367.
17. Ma X. 2001. TNF-alpha and IL-12: a balancing act in macrophage functioning. Microbes Infect 3: 121-129.
18. Matsukawa A, Hogaboam CM, Lukacs NW, Kunkel SL. 2000. Chemokines and innate immunity. Rev Immunogenet 2: 339-358.
19. Moeslinger T, Friedl R, Volf I, Brunner M, Koller E, Spieckermann PG. 2000. Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line. Can J Physiol Pharmacol 78: 861-866.
20. Moncada S, Palmer RMJ, Higgs EA. 1991. Nitric oxide physiology, pathophysiology and pharmacology. Pharmacol Rev 43: 109-142.
21. Moroney MA, Alcaraz MJ, Forder RA, Hoult JR. 1988. Selectivity of neutrophil 5-lipoxygenase and cyclooxygenase inhibition by an antiinflammatory flavonoid glycoside and related aglycone flavonoid. J Pharm Pharmacol 40: 787-792.
22. Okpanyi SN, Ezeukwu GC. 1981. Antiinflammatory and antipyretic activities of Azadirachta indica. Planta Med 41: 34-39.
23. Pillai NR, Santhakumari G. 1981. Anti-arthritic and anti-inflammatory actions of nimbidin. Planta Med 43: 59-63.
24. Salvemini D, Wang ZQ, Wyatt PS, et al. 1996. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br J Pharmacol 118: 829-838.
25. Siddiqui S, Mitra CR. 1945. Utilization of nim oil and its bitter constituents (nimbidin series) in the pharmaceutical industry. J Sci Indian Res 4: 5-10.
26. Smith RJ, Iden SS. 1979. Phorbol myristate acetate-induced release of granule enzymes from human neutrophils: inhibition by the calcium antagonist, 8-(N,N-diethylamino)-octyl 3,4,5-trimethoxybenzoate hydrochloride. Biochem Biophys Res Commun 91: 263-271.
27. Van der Nat JM, van der Sluis WG, de Silva KT, Labadie RP. 1991. Ethnopharmacognostical survey of Azadirachta indica A. Juss (Meliaceae). J Ethnopharmacol 35: 1-24.
28. Vane JR, Bakle YS, Botting RM. 1998. Cycloxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38: 97-120.