Experimental spinal cord ischemia: Model characterization and improved outcome with arterial hypertension

Critical Care Medicine

Volumn 32, Issue 6, 2004, Pages 1346-1351

  Toung, Thomas J K ^a   Chang, Yi ^a   Williams, Mel ^a   Crain, Barbara J ^a   Traystman, Richard J ^b   Bhardwaj, Anish ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Aorta; Cord; Ischemia; Paraplegia; Rat; Spine

Indexed keywords

HALOTHANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CLAMPING; AORTA OCCLUSION; ARTICLE; ATAXIA; BLOOD PRESSURE MONITORING; BODY TEMPERATURE; CANNULA; CAROTID ARTERY; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; DESCENDING AORTA; ENDOTRACHEAL INTUBATION; GAIT DISORDER; HISTOPATHOLOGY; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; MOTONEURON; MOTOR PERFORMANCE; NEUROLOGIC DISEASE; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT; SCORING SYSTEM; SPINAL CORD ISCHEMIA; SPINAL CORD VENTRAL HORN; THORACOTOMY;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; HYPERTENSION; MALE; MOTOR NEURONS; PARAPLEGIA; PROSPECTIVE STUDIES; RANDOM ALLOCATION; RATS; RATS, WISTAR; SPINAL CORD ISCHEMIA;

EID: 2942532323     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000128562.80108.61     Document Type: Article

References (38)

1. Bachet J, Guilmet D, Rosier J, et al: Protection of spinal cord during surgery of thoracoabdominal aortic aneurysms. Eur J Cardiothorac Surg 1996; 10:817-825
2. Coselli JS, LeMaire SA, de Figueiredo LP, et al: Paraplegia after thoracoabdominal aortic aneurysm repair: Is dissection a risk factor? Ann Thorac Surg 1997; 63:28-35
3. Mastroroberto P, Chello M: Emergency thoracoabdominal aortic aneurysm repair: Clinical outcome. J Thorac Cardiovasc Surg 1999; 118:477-481
4. Coselli JS, Conklin LD, LeMaire SA: Thoracoabdominal aortic aneurysm repair: Review and update of current strategies. Ann Thorac Surg 2002; 74:81881-81884
5. Coselli JS, LeMaire SA, Conklin LD, et al: Morbidity and mortality after extent II thoracoabdominal aortic aneurysm repair. Ann Thorac Surg 2002; 73:1107-1115
6. Cheung AT, Weiss SJ, McGarvey ML, et al: Interventions for reversing delayed-onset postoperative paraplegia after thoracic aortic reconstruction. Ann Thorac Surg 2002; 74:413-419
7. Schepens MA, Defauw JJ, Hamerlijnck RP, et al: Surgical treatment of thoracoabdominal aortic aneurysms by simple crossclamping. Risk factors and late results. J Thorac Cardiovasc Surg 1994; 107:134-142
8. Bhardwaj A, Long DM, Ducker TB, et al: Neurological deficits following cervical laminectomy in the prone position. J Neurosurg Anesthesiol 2001; 13:314-319
9. Crawford ES, Svensson LG, Hess KR, et al: A prospective randomized study of cerebrospinal fluid drainage to prevent paraplegia after high-risk surgery on the thoracoabdominal aorta. J Vasc Surg 1991; 13:36-45
10. Lapchak PA, Araujo DM, Song D, et al: Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in neurobehavioral deficits induced by reversible spinal cord ischemia. Stroke 2001; 32:1220-1225
11. Lips J, de Haan P, Bodewits P, et al: Neuroprotective effects of riluzole and ketamine during transient spinal cord ischemia in the rabbit. Anesthesiology 2000; 93:1303-1311
12. DeGirolami U, Zivin JA: Neuropathology of spinal cord ischemia in the rabbit. J Neuropathol Exp Neurol 1982; 41:129-149
13. Gilad GM, Gilad VH: Accelerated functional recovery and neuroprotection by agmantine after spinal cord ischemia in rats. Neurosci Lett 2000; 296:97-100
14. Sufianova GZ, Usov LA, Sufianov AA, et al: New minimally invasive model of spinal cord ischemia in rats. Bull Exp Biol Med 2002; 133:98-101
15. Lang-Lazdunski L, Heurteaux C, Dupont H, et al: The effects of FK506 on neurologic and histopathologic outcome after transient spinal cord ischemia induced by aortic cross-clamping in rats. Anesth Analg 2001; 92:1237-1244
16. LeMay DR, Zelenock GB, D'Alecy LG: The role of glucose uptake and metabolism in hyperglycemic exacerbation of neurologic deficit in the paraplegic rat. J Neurosurg 1989; 71:594-600
17. LeMay DR, Zelenock GB, D'Alecy LG: Neurological protection by dichloroacetate depending on the severity of injury in the paraplegic rat. J Neurosurg 1990; 73:118-122
18. Kapinya KJ, Lowl D, Futterer C, et al: Tolerance against ischemic neuronal injury can be induced by volatile anesthetics and is inducible NO synthase dependent. Stroke 2002; 33:1889-1898
19. Bhardwaj A, Castro AF III, Alkayed NJ, et al: Anesthetic choice of halothane versus propofol: Impact on experimental perioperative stroke. Stroke 2001; 32:1920-1925
20. Tveten L: Spinal cord vascularity. III. The spinal cord arteries in man. Acta Radiologica Diagn 1976; 17:257-273
21. Woolman DHM, Miller JW: The arterial supply of the spinal cord and its significance. J Neurol Neurosurg Psychiatry 1955; 18:97-102
22. Fried LC, Doppman J: The arterial supply to the lumbo-sacral spinal cord in the monkey: A comparison with man. Anat Rec 1974; 178:41-48
23. Coston A, Laville M, Baud P, et al: Aortic occlusion by a balloon catheter: A method to induce hind limb rigidity in rats. Physiol Behav 1983; 30:967-969
24. Lang-Lazdunski L, Matsushita K, Hirt L, et al: Spinal cord ischemia. Development of a model in the mouse. Stroke 2000; 31:208-213
25. Marsala M, Sorkin LS, Yaksh TL: Transient spinal ischemia in rat: Characterization of spinal cord blood flow, extracellular amino acid release, and concurrent histopathological damage. J Cereb Blood Flow Metab 1994; 14:604-614
26. Qayumi AK, Janusz MT, Lyster DM, et al: Animal model for investigation of spinal cord injury caused by aortic cross-clamping. J Invest Surg 1997; 10:47-52
27. Wisslink W, Nguyen JH, Becker MO, et al: Ischemia-reperfusion injury of the spinal cord: The influence of normovolemic hemodilution and gradual reperfusion. Cardiovasc Surg 1995; 3:399-404
28. Sakamoto T, Kawaguchi M, Kurita N, et al: Long-term assessment of hind limb motor function and neuronal injury following spinal cord ischemia in rats. J Neurosurg Anesthesiol 2003; 15:104-109
29. Lu K, Liang CL, Chen HJ, et al: Injury severity and cell death mechanisms: Effects of concomitant hypovolemic hypotension on spinal cord ischemia-reperfusion in rats. Exp Neurol 2004; 185:120-132
30. Rordorf G, Koroshetz WJ, Ezzeddine MA, et al: A pilot study of drug-induced hypertension for treatment of acute stroke. Neurology 2001; 56:1210-1213
31. Hillis AE, Kane A, Tuffiash E, et al: Reperfusion of specific regions by raising blood pressure restores selective language functions in subacute stroke. Brain Lang 2001; 79:495-510
32. Smith JS, Roizen MF, Calahan MK, et al: Does anesthetic technique make a difference? Augmentation of systolic blood pressure during carotid endarterectomy: Effects of phenylephrine versus light anesthesia and of isoflurane versus halothane on the incidence of myocardial ischemia. Anesthesiol 1988; 69:846-855
33. Vale FL, Burns J, Jackson AB, et al: Combined medical and surgical treatment after acute spinal cord injury: Results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management. J Neurosurg 1997; 87:239-246
34. Haan P, Kalkman CJ, Jacobs MJH: Pharmacologie neuroprotection in experimental spinal cord ischemia. A systematic review. J Neurosurg Anesthesiol 2001; 13:3-12
35. Basu S, Hellberg A, Ulus AT, et al: Biomarkers of free radical injury during spinal cord ischemia. FEBS Lett 2001; 508:36-38
36. Connolly JE: Prevention of paraplegia secondary to operations on the aorta. J Cardiovasc Surg 1986; 27:410-417
37. Shamji MF, Maziak DE, Shamji FM, et al: Circulation of the spinal cord: an important consideration for thoracic surgeons. Ann Thorac Surg 2003; 76:315-321
38. Robertazzi RR, Acinapura AJ: The efficacy of left atrial to femoral artery bypass in the prevention of spinal cord ischemia during aortic surgery. Semin Thorac Cardiovasc 1998; 10:67-71