Long-term assessment of hind limb motor function and neuronal injury following spinal cord ischemia in rats

Journal of Neurosurgical Anesthesiology

Volumn 15, Issue 2, 2003, Pages 104-109

  Sakamoto, Takanori ^a   Kawaguchi, Masahiko ^a   Kurita, Naoko ^a   Horiuchi, Toshinori ^a   Kakimoto, Meiko ^a   Inoue, Satoki ^a   Furuya, Hitoshi ^a   Nakamura, Mitsutoshi ^a   Konishi, Noboru ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Motor function; Necrosis; Neuron; Paraplegia; Spinal cord ischemia

Indexed keywords

EOSIN; HEMATOXYLIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; CONVALESCENCE; HINDLIMB; MALE; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; SPINAL CORD ISCHEMIA; SPINAL CORD TRANSSECTION;

ANIMALS; BLOOD GAS ANALYSIS; BLOOD PRESSURE; BODY TEMPERATURE; HINDLIMB; ISCHEMIA; MALE; NECROSIS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0037386130     PISSN: 08984921     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008506-200304000-00007     Document Type: Article

References (18)

1. Svensson LG, Crawford ES, Hess KR, et al. Experience with 1509 patients undergoing thoracoabdominal aortic operations. J Vasc Surg 1993;17:357-70.
2. Wan IYP, Angelini GD, Bryan AJ, et al. Prevention of spinal cord ischaemia during descending thoracic and thoracoabdominal aortic surgery. Eur J Cardiothorac Surg 2001;19:203-13.
3. Coselli JS, LeMaire SA, Conklin LD, et al. Morbidity and mortality after extent II thoracoabdominal aortic aneurysm repair. Ann Thorac Surg 2002;73:1107-16.
4. Derrow AE, Seeger JM, Dame DA, et al. The outcome in the United States after thoracoabdominal aortic aneurysm repair, renal artery bypass, and mesenteric revascularization. J Vasc Surg 2001;34:54-61.
5. Crawford ES, Mizafi EM, Hess KR, et al. The impact of aortic perfusion and SSEP monitoring on prevention of paraplegia after aortic operations. J Thorac Cardiovasc Surg 1988;95:356-7.
6. Moore WM, Hollier LY. The influence of severity of spinal cord ischemia in the etiology of delayed-onset paraplegia. Ann Surg 1991;213:427-32.
7. Du C, Hu R, Csemansky CA, et al. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J Cereb Blood Flow Metab 1996;16:195-201.
8. Kawaguchi M, Kimbro JR, Drummond JC, et al. Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. Anesthesiology 2000;92:1335-42.
9. Nakano S, Kogure K, Fujikura H. Ischemia-induced slowly progressive neuronal damage in the rat brain. Neuroscience 1990;38:115-24.
10. Garcia JH, Liu KF, Ye ZR, et al. Incomplete infarct and delayed neuronal death after transient middle cerebral artery occlusion in rats. Stroke 1997;28:2303-10.
11. Sakurai M, Aoki M, Abe K, et al. Selective motor neuron death and heat shock protein induction after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 1997;113:159-64.
12. Sakurai M, Hayashi T, Abe K, et al. Delayed and selective motor neuron death after transient spinal cord ischemia: a role of apoptosis? J Thorac Cardiovasc Surg 1998;115:1310-5.
13. Taira Y, Marsala M. Effects of proximal arterial perfusion pressure on function, spinal cord blood flow, and histopathologic changes after increasing intervals of aortic occlusion in the rat. Stroke 1996;27:1850-8.
14. Marsala M, Vanicky I, Yaksh TL. Effect of graded hypothermia (27° to 24°C) on behavioral function, histopathology, and spinal blood flow after spinal ischemia in rat. Stroke 1994;25:2038-46.
15. Kakinohana M, Taira Y, Marsala M. The effect of graded postischemic spinal cord hypothermia on neurological outcome and histopathology after transient spinal ischemia in rat. Anesthesiology 1999;90:789-98.
16. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995;12:1-21.
17. Kanellopoulos GK, Kato H, Wu Y, et al. Neuronal cell death in the ischemic spinal cord: the effect of methylprednisolone. Ann Thorac Surg 1997;64:1279-86.
18. Kato H, Kanellopoulos GK, Matsuo S, et al. Neuronal apoptosis and necrosis following spinal cord ischemia in the rat. Exp Neurol 1997;148:464-74.