The first γ-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus

Journal of Biological Chemistry

Volumn 279, Issue 31, 2004, Pages 32453-32463

  Hansson, Karin ^a   Ma, Xiaosong ^a   Eliasson, Lena ^a   Czerwiec, Eva ^b   Furie, Bruce ^b,c   Furie, Barbara C ^b,c   Rorsman, Patrik ^a,d   Stenflo, Johan ^a  

^a LUND UNIVERSITY   (Sweden)

^b MARINE BIOLOGICAL LABORATORY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARBOXYLIC ACIDS; HYDROXYLATION; IONIZATION; ISOMERIZATION; MASS SPECTROMETRY;

CALCIUM ION CHANNEL; CONOPETIDES;

BIOCHEMISTRY;

4 CARBOXYGLUTAMIC ACID; CALCIUM CHANNEL L TYPE; CONTRYPHAN; SNAIL VENOM; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CHANNEL GATING; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN ISOLATION; TANDEM MASS SPECTROMETRY;

1-CARBOXYGLUTAMIC ACID; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CALCIUM; CALCIUM CHANNELS; CATIONS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISULFIDES; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HYDROLYSIS; IONS; KINETICS; MOLECULAR SEQUENCE DATA; MOLLUSK VENOMS; PEPTIDE BIOSYNTHESIS; PEPTIDES; PEPTIDES, CYCLIC; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SNAILS; SPECTROMETRY, FLUORESCENCE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS; TRYPTOPHAN;

ANIMALIA; CONUS MARMOREUS; GASTROPODA; VERTEBRATA;

EID: 2942529410     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313825200     Document Type: Article

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