-
1
-
-
4344684281
-
Clinical and immunologic effects of subcutaneously administered interleukin-12 and interferon alfa-2b: Phase I trial of patients with metastatic renal cell carcinoma or malignant melanoma
-
Alatrash, G., Hutson, T. E., Molto, L., Richmond, A., Nemec, C., Mekhail, T., Elson, P., et al. (2004) Clinical and immunologic effects of subcutaneously administered interleukin-12 and interferon alfa-2b: phase I trial of patients with metastatic renal cell carcinoma or malignant melanoma. J. Clin. Oncol. 22: 2891-900.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 2891-2900
-
-
Alatrash, G.1
Hutson, T.E.2
Molto, L.3
Richmond, A.4
Nemec, C.5
Mekhail, T.6
Elson, P.7
-
2
-
-
0033692861
-
Adenovirus-interleukin-12-mediated tumor regression in a murine hepatocellular carcinoma model is not dependent on CD1-restricted natural killer T cells
-
Andrews, K. J., Ribas, A., Butterfield, L. H., Vollmer, C. M., Eilber, F. C., Dissette, V. B., Nelson, S. D., et al. (2000) Adenovirus-interleukin-12-mediated tumor regression in a murine hepatocellular carcinoma model is not dependent on CD1-restricted natural killer T cells. Cancer Res. 60: 6457-64.
-
(2000)
Cancer Res.
, vol.60
, pp. 6457-6464
-
-
Andrews, K.J.1
Ribas, A.2
Butterfield, L.H.3
Vollmer, C.M.4
Eilber, F.C.5
Dissette, V.B.6
Nelson, S.D.7
-
3
-
-
0032904888
-
Transfer of the murine interleukin-12 gene in. vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography
-
Asselin-Paturel, C., Lassau, N., Guinebretiere, J. M., Zhang, J., Gay, F., Bex, F., Hallez, S., et al. (1999) Transfer of the murine interleukin-12 gene in. vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography. Gene Ther. 6: 606-15.
-
(1999)
Gene Ther.
, vol.6
, pp. 606-615
-
-
Asselin-Paturel, C.1
Lassau, N.2
Guinebretiere, J.M.3
Zhang, J.4
Gay, F.5
Bex, F.6
Hallez, S.7
-
4
-
-
0035197719
-
Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12
-
Barajas, M., Mazzolini, G., Genove, G., Bilbao, R., Narvaiza, I., Schmitz, V., Sangro, B., et al. (2001) Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12. Hepatology 33: 52-61.
-
(2001)
Hepatology
, vol.33
, pp. 52-61
-
-
Barajas, M.1
Mazzolini, G.2
Genove, G.3
Bilbao, R.4
Narvaiza, I.5
Schmitz, V.6
Sangro, B.7
-
5
-
-
0034980245
-
Interleukin 12 secretion enhances antitumor efficacy of oncolytic herpes simplex viral therapy for colorectal cancer
-
Bennett, J. J., Malhotra, S., Wong, R. J., Delman, K., Zager, J., St-Louis, M., Johnson, P., et al. (2001) Interleukin 12 secretion enhances antitumor efficacy of oncolytic herpes simplex viral therapy for colorectal cancer. Ann. Surg. 233: 819-26.
-
(2001)
Ann. Surg.
, vol.233
, pp. 819-826
-
-
Bennett, J.J.1
Malhotra, S.2
Wong, R.J.3
Delman, K.4
Zager, J.5
St-Louis, M.6
Johnson, P.7
-
6
-
-
0034649786
-
Ability of systemic interleukin-12 to hamper progressive stages of mammary carcinogenesis in HER2/neu transgenic mice
-
Boggio, K., Di Carlo, E., Rovero, S., Cavallo, F., Quaglino, E., Lollini, P. L., Nanni, P., et al. (2000) Ability of systemic interleukin-12 to hamper progressive stages of mammary carcinogenesis in HER2/neu transgenic mice. Cancer Res. 60: 359-64.
-
(2000)
Cancer Res.
, vol.60
, pp. 359-364
-
-
Boggio, K.1
Di Carlo, E.2
Rovero, S.3
Cavallo, F.4
Quaglino, E.5
Lollini, P.L.6
Nanni, P.7
-
7
-
-
0030057511
-
Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: In vitro and in vivo production of biologically active interleukin-12
-
Bramson, J., Hitt, M., Gallichan, W. S., Rosenthal, K. L., Gauldie, J. and Graham, F. L. (1996) Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: in vitro and in vivo production of biologically active interleukin-12. Hum. Gene Ther. 7: 333-42.
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 333-342
-
-
Bramson, J.1
Hitt, M.2
Gallichan, W.S.3
Rosenthal, K.L.4
Gauldie, J.5
Graham, F.L.6
-
8
-
-
0029848051
-
Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12
-
Bramson, J. L., Hitt, M., Addison, C. L., Muller, W. J., Gauldie, J. and Graham, F. L. (1996) Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12. Hum. Gene Ther. 7: 1995-2002.
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 1995-2002
-
-
Bramson, J.L.1
Hitt, M.2
Addison, C.L.3
Muller, W.J.4
Gauldie, J.5
Graham, F.L.6
-
9
-
-
0029859405
-
Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma
-
Caruso, M., Pham-Nguyen, K., Kwong, Y. L., Xu, B., Kosai, K. I., Finegold, M., Woo, S. L., et al. (1996) Adenovirus-mediated interleukin-12 gene therapy for metastatic colon carcinoma. Proc. Natl. Acad. Sci. USA 93: 11302-6.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 11302-11306
-
-
Caruso, M.1
Pham-Nguyen, K.2
Kwong, Y.L.3
Xu, B.4
Kosai, K.I.5
Finegold, M.6
Woo, S.L.7
-
10
-
-
0036005890
-
Interleukin-12 in anti-tumor immunity and immunotherapy
-
Colombo, M. P. and Trinchieri, G. (2002) Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev. 13: 155-68.
-
(2002)
Cytokine Growth Factor Rev.
, vol.13
, pp. 155-168
-
-
Colombo, M.P.1
Trinchieri, G.2
-
11
-
-
0029898839
-
Amount of interleukin 12 available at the tumor site is critical for tumor regression
-
Colombo, M. P., Vagliani, M., Spreafico, F., Parenza, M., Chiodoni, C., Melani, C. and Stoppacciaro, A. (1996) Amount of interleukin 12 available at the tumor site is critical for tumor regression. Cancer Res. 56: 2531-4.
-
(1996)
Cancer Res.
, vol.56
, pp. 2531-2534
-
-
Colombo, M.P.1
Vagliani, M.2
Spreafico, F.3
Parenza, M.4
Chiodoni, C.5
Melani, C.6
Stoppacciaro, A.7
-
12
-
-
2542609804
-
Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12-engineered allogeneic cell vaccine
-
De Giovanni, C., Nicoletti, G., Landuzzi, L., Astolfi, A., Croci, S., Comes, A., Ferrini, S., et al. (2004) Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12-engineered allogeneic cell vaccine. Cancer Res. 64: 4001-9.
-
(2004)
Cancer Res.
, vol.64
, pp. 4001-4009
-
-
De Giovanni, C.1
Nicoletti, G.2
Landuzzi, L.3
Astolfi, A.4
Croci, S.5
Comes, A.6
Ferrini, S.7
-
13
-
-
0034069130
-
Anti-tumor immunity induced by interleukin-12 gene therapy in a metastatic model of breast cancer is mediated by natural killer cells
-
Divino, C. M., Chen, S. H., Yang, W., Thung, S., Brower, S. T. and Woo, S. L. (2000) Anti-tumor immunity induced by interleukin-12 gene therapy in a metastatic model of breast cancer is mediated by natural killer cells. Breast Cancer Res. Treat. 60: 129-34.
-
(2000)
Breast Cancer Res. Treat.
, vol.60
, pp. 129-134
-
-
Divino, C.M.1
Chen, S.H.2
Yang, W.3
Thung, S.4
Brower, S.T.5
Woo, S.L.6
-
14
-
-
0033973785
-
Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcinoma
-
Drozdzik, M., Qian, C., Xie, X., Peng, D., Bilbao, R., Mazzolini, G. and Prieto, J. (2000) Combined gene therapy with suicide gene and interleukin-12 is more efficient than therapy with one gene alone in a murine model of hepatocellular carcinoma. J. Hepatol. 32: 279-86.
-
(2000)
J. Hepatol.
, vol.32
, pp. 279-286
-
-
Drozdzik, M.1
Qian, C.2
Xie, X.3
Peng, D.4
Bilbao, R.5
Mazzolini, G.6
Prieto, J.7
-
15
-
-
0034660885
-
In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: Induction of tumor regression and potent antitumor immunity
-
Egilmez, N. K., Jong, Y. S., Sabel, M. S., Jacob, J. S., Mathiowitz, E. and Bankert, R. B. (2000) In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity. Cancer Res. 60: 3832-7.
-
(2000)
Cancer Res.
, vol.60
, pp. 3832-3837
-
-
Egilmez, N.K.1
Jong, Y.S.2
Sabel, M.S.3
Jacob, J.S.4
Mathiowitz, E.5
Bankert, R.B.6
-
16
-
-
22044438503
-
Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8
-
Feijoo, E., Alfaro, C., Mazzolini, G., Serra, P., Penuelas, I., Arina, A., Huarte, E., et al. (2005) Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8. Int. J. Cancer.
-
(2005)
Int. J. Cancer.
-
-
Feijoo, E.1
Alfaro, C.2
Mazzolini, G.3
Serra, P.4
Penuelas, I.5
Arina, A.6
Huarte, E.7
-
17
-
-
0033855120
-
Spleen-derived dendritic cells engineered to enhance interleukin-12 production elicit therapeutic antitumor immune responses
-
Furumoto, K., Arii, S., Yamasaki, S., Mizumoto, M., Mori, A., Inoue, N., Isobe, N., et al. (2000) Spleen-derived dendritic cells engineered to enhance interleukin-12 production elicit therapeutic antitumor immune responses. Int. J. Cancer 87: 665-72.
-
(2000)
Int. J. Cancer
, vol.87
, pp. 665-672
-
-
Furumoto, K.1
Arii, S.2
Yamasaki, S.3
Mizumoto, M.4
Mori, A.5
Inoue, N.6
Isobe, N.7
-
18
-
-
0032609944
-
Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12
-
Gambotto, A., Tuting, T., McVey, D. L., Kovesdi, I., Tahara, H., Lotze, M. T. and Robbins, P. D. (1999) Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12. Cancer Gene Ther. 6: 45-53.
-
(1999)
Cancer Gene Ther.
, vol.6
, pp. 45-53
-
-
Gambotto, A.1
Tuting, T.2
McVey, D.L.3
Kovesdi, I.4
Tahara, H.5
Lotze, M.T.6
Robbins, P.D.7
-
19
-
-
0031711866
-
Rapid recruitment of macrophages in interleukin-12-mediated tumour regression
-
Ha, S. J., Lee, S. B., Kim, C. M., Shin, H. S. and Sung, Y. C. (1998) Rapid recruitment of macrophages in interleukin-12-mediated tumour regression. Immunology 95: 156-63.
-
(1998)
Immunology
, vol.95
, pp. 156-163
-
-
Ha, S.J.1
Lee, S.B.2
Kim, C.M.3
Shin, H.S.4
Sung, Y.C.5
-
20
-
-
0032708410
-
Interleukin-12 activates NK cells for IFN-gamma-dependent and NKT cells for IFN-gamma-independent antimetastatic activity
-
Hafner, M., Falk, W., Echtenacher, B. and Mannel, D. N. (1999) Interleukin-12 activates NK cells for IFN-gamma-dependent and NKT cells for IFN-gamma-independent antimetastatic activity. Eur. Cytokine Netw. 10: 541-8.
-
(1999)
Eur. Cytokine Netw.
, vol.10
, pp. 541-548
-
-
Hafner, M.1
Falk, W.2
Echtenacher, B.3
Mannel, D.N.4
-
21
-
-
0034465697
-
Tumor regression induced by intratumoral injection of DNA coding for human interleukin 12 into melanoma metastases in gray horses
-
Heinzerling, L. M., Feige, K., Rieder, S., Akens, M. K., Dummer, R., Stranzinger, G. and Moelling, K. (2001) Tumor regression induced by intratumoral injection of DNA coding for human interleukin 12 into melanoma metastases in gray horses. J. Mol. Med. 78: 692-702.
-
(2001)
J. Mol. Med.
, vol.78
, pp. 692-702
-
-
Heinzerling, L.M.1
Feige, K.2
Rieder, S.3
Akens, M.K.4
Dummer, R.5
Stranzinger, G.6
Moelling, K.7
-
22
-
-
0033218093
-
Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma
-
Hirschowitz, E. A., Naama, H. A., Evoy, D., Lieberman, M. D., Daly, J. and Crystal, R. G. (1999) Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma. Cancer Gene Ther. 6: 491-8.
-
(1999)
Cancer Gene Ther.
, vol.6
, pp. 491-498
-
-
Hirschowitz, E.A.1
Naama, H.A.2
Evoy, D.3
Lieberman, M.D.4
Daly, J.5
Crystal, R.G.6
-
23
-
-
0033766179
-
Prostate cancer gene therapy: Comparison of adenovirus-mediated expression of interleukin 12 with interleukin 12 plus B7-1 for in situ gene therapy and gene-modified, cell-based vaccines
-
Hull, G. W., McCurdy, M. A., Nasu, Y., Bangma, C. H., Yang, G., Shimura, S., Lee, H. M., et al. (2000) Prostate cancer gene therapy: comparison of adenovirus-mediated expression of interleukin 12 with interleukin 12 plus B7-1 for in situ gene therapy and gene-modified, cell-based vaccines. Clin. Cancer Res. 6: 4101-9.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 4101-4109
-
-
Hull, G.W.1
McCurdy, M.A.2
Nasu, Y.3
Bangma, C.H.4
Yang, G.5
Shimura, S.6
Lee, H.M.7
-
24
-
-
9144262941
-
Interleukin-12 genetic administration suppressed metastatic liver tumor unsusceptible to CTL
-
Itokawa, Y., Mazda, O., Ueda, Y., Kishida, T., Asada, H., Cui, F. D., Fuji, N., et al. (2004) Interleukin-12 genetic administration suppressed metastatic liver tumor unsusceptible to CTL. Biochem. Biophys. Res. Commun. 314: 1072-9.
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.314
, pp. 1072-1079
-
-
Itokawa, Y.1
Mazda, O.2
Ueda, Y.3
Kishida, T.4
Asada, H.5
Cui, F.D.6
Fuji, N.7
-
25
-
-
0034061526
-
Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model
-
Jarnagin, W. R., Delman, K., Kooby, D., Mastorides, S., Zager, J., Brennan, M. F., Blumgart, L. H., et al. (2000) Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model. Ann. Surg. 231: 762-71.
-
(2000)
Ann. Surg.
, vol.231
, pp. 762-771
-
-
Jarnagin, W.R.1
Delman, K.2
Kooby, D.3
Mastorides, S.4
Zager, J.5
Brennan, M.F.6
Blumgart, L.H.7
-
26
-
-
20544471876
-
Combined Analysis of Efficacy: The Addition of Bevacizumab to Fluorouracil/Leucovorin Improves Survival for Patients With Metastatic Colorectal Cancer
-
Kabbinavar, F. F., Hambleton, J., Mass, R. D., Hurwitz, H. I., Bergsland, E. and Sarkar, S. (2005) Combined Analysis of Efficacy: The Addition of Bevacizumab to Fluorouracil/Leucovorin Improves Survival for Patients With Metastatic Colorectal Cancer. J. Clin. Oncol..
-
(2005)
J. Clin. Oncol.
-
-
Kabbinavar, F.F.1
Hambleton, J.2
Mass, R.D.3
Hurwitz, H.I.4
Bergsland, E.5
Sarkar, S.6
-
27
-
-
0035831628
-
Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: Outcome of a phase I study
-
Kang, W. K., Park, C., Yoon, H. L., Kim, W. S., Yoon, S. S., Lee, M. H., Park, K., et al. (2001) Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a phase I study. Hum. Gene Ther. 12: 671-84.
-
(2001)
Hum. Gene Ther.
, vol.12
, pp. 671-684
-
-
Kang, W.K.1
Park, C.2
Yoon, H.L.3
Kim, W.S.4
Yoon, S.S.5
Lee, M.H.6
Park, K.7
-
28
-
-
12444260282
-
An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4
-
Lasagni, L., Francalanci, M., Annunziato, F., Lazzeri, E., Giannini, S., Cosmi, L., Sagrinati, C., et al. (2003) An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J. Exp. Med. 197: 1537-49.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1537-1549
-
-
Lasagni, L.1
Francalanci, M.2
Annunziato, F.3
Lazzeri, E.4
Giannini, S.5
Cosmi, L.6
Sagrinati, C.7
-
29
-
-
0030766971
-
Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production
-
Leonard, J. P., Sherman, M. L., Fisher, G. L., Buchanan, L. J., Larsen, G., Atkins, M. B., Sosman, J. A., et al. (1997) Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 90: 2541-8.
-
(1997)
Blood
, vol.90
, pp. 2541-2548
-
-
Leonard, J.P.1
Sherman, M.L.2
Fisher, G.L.3
Buchanan, L.J.4
Larsen, G.5
Atkins, M.B.6
Sosman, J.A.7
-
30
-
-
85047700220
-
In situ adenoviral interleukin 12 gene transfer confers potent and long-lasting cytotoxic immunity in glioma
-
Liu, Y., Ehtesham, M., Samoto, K., Wheeler, C. J., Thompson, R. C., Villarreal, L. P., Black, K. L., et al. (2002) In situ adenoviral interleukin 12 gene transfer confers potent and long-lasting cytotoxic immunity in glioma. Cancer Gene Ther. 9: 9-15.
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 9-15
-
-
Liu, Y.1
Ehtesham, M.2
Samoto, K.3
Wheeler, C.J.4
Thompson, R.C.5
Villarreal, L.P.6
Black, K.L.7
-
31
-
-
0032478270
-
Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma
-
Lode, H. N., Dreier, T., Xiang, R., Varki, N. M., Kang, A. S. and Reisfeld, R. A. (1998) Gene therapy with a single chain interleukin 12 fusion protein induces T cell-dependent protective immunity in a syngeneic model of murine neuroblastoma. Proc. Natl. Acad. Sci. USA 95: 2475-80.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2475-2480
-
-
Lode, H.N.1
Dreier, T.2
Xiang, R.3
Varki, N.M.4
Kang, A.S.5
Reisfeld, R.A.6
-
32
-
-
6444226744
-
Treatment with IL-2 and IL-12 inhibits tumour cell division in SL2 lymphoma
-
Masztalerz, A., Van Luyn, M., Werner, N., Molema, G., Everse, L. A. and Otter, W. D. (2004) Treatment with IL-2 and IL-12 inhibits tumour cell division in SL2 lymphoma. Anticancer Res. 24: 2633-42.
-
(2004)
Anticancer Res.
, vol.24
, pp. 2633-2642
-
-
Masztalerz, A.1
Van Luyn, M.2
Werner, N.3
Molema, G.4
Everse, L.A.5
Otter, W.D.6
-
33
-
-
20044396550
-
Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas
-
Mazzolini, G., Alfaro, C., Sangro, B., Feijoo, E., Ruiz, J., Benito, A., Tirapu, I., et al. (2005) Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas. J. Clin. Oncol. 23: 999-1010.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 999-1010
-
-
Mazzolini, G.1
Alfaro, C.2
Sangro, B.3
Feijoo, E.4
Ruiz, J.5
Benito, A.6
Tirapu, I.7
-
34
-
-
0034980715
-
Alpha(v)beta(3) integrin-mediated adenoviral transfer of interleukin-12 at the periphery of hepatic colon cancer metastases induces VCAM-1 expression and T-cell recruitment
-
Mazzolini, G., Narvaiza, I., Bustos, M., Duarte, M., Tirapu, I., Bilbao, R., Qian, C., et al. (2001) Alpha(v)beta(3) integrin-mediated adenoviral transfer of interleukin-12 at the periphery of hepatic colon cancer metastases induces VCAM-1 expression and T-cell recruitment. Mol. Ther. 3: 665-72.
-
(2001)
Mol. Ther.
, vol.3
, pp. 665-672
-
-
Mazzolini, G.1
Narvaiza, I.2
Bustos, M.3
Duarte, M.4
Tirapu, I.5
Bilbao, R.6
Qian, C.7
-
35
-
-
0035080357
-
Genetic heterogeneity in the toxicity to systemic adenoviral gene transfer of interleukin-12
-
Mazzolini, G., Narvaiza, I., Perez-Diez, A., Rodriguez-Calvillo, M., Qian, C., Sangro, B., Ruiz, J., et al. (2001) Genetic heterogeneity in the toxicity to systemic adenoviral gene transfer of interleukin-12. Gene Ther. 8: 259-67.
-
(2001)
Gene Ther.
, vol.8
, pp. 259-267
-
-
Mazzolini, G.1
Narvaiza, I.2
Perez-Diez, A.3
Rodriguez-Calvillo, M.4
Qian, C.5
Sangro, B.6
Ruiz, J.7
-
36
-
-
0033971393
-
Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level
-
Mazzolini, G., Qian, C., Narvaiza, I., Barajas, M., Borras-Cuesta, F., Xie, X., Duarte, M., et al. (2000) Adenoviral gene transfer of interleukin 12 into tumors synergizes with adoptive T cell therapy both at the induction and effector level. Hum. Gene Ther. 11: 113-25.
-
(2000)
Hum. Gene Ther.
, vol.11
, pp. 113-125
-
-
Mazzolini, G.1
Qian, C.2
Narvaiza, I.3
Barajas, M.4
Borras-Cuesta, F.5
Xie, X.6
Duarte, M.7
-
37
-
-
0033218662
-
Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12
-
Mazzolini, G., Qian, C., Xie, X., Sun, Y., Lasarte, J. J., Drozdzik, M. and Prieto, J. (1999) Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12. Cancer Gene Ther. 6: 514-22.
-
(1999)
Cancer Gene Ther.
, vol.6
, pp. 514-522
-
-
Mazzolini, G.1
Qian, C.2
Xie, X.3
Sun, Y.4
Lasarte, J.J.5
Drozdzik, M.6
Prieto, J.7
-
38
-
-
0032844949
-
Intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas
-
Melero, I., Duarte, M., Ruiz, J., Sangro, B., Galofre, J., Mazzolini, G., Bustos, M., et al. (1999) intratumoral injection of bone-marrow derived dendritic cells engineered to produce interleukin-12 induces complete regression of established murine transplantable colon adenocarcinomas. Gene Ther. 6: 1779-84.
-
(1999)
Gene Ther.
, vol.6
, pp. 1779-1784
-
-
Melero, I.1
Duarte, M.2
Ruiz, J.3
Sangro, B.4
Galofre, J.5
Mazzolini, G.6
Bustos, M.7
-
39
-
-
0032520919
-
Interleukin 12 gene therapy of MHC-negative murine melanoma metastases
-
Nanni, P., Rossi, I., De Giovanni, C., Landuzzi, L., Nicoletti, G., Stoppacciaro, A., Parenza, M., et al. (1998) Interleukin 12 gene therapy of MHC-negative murine melanoma metastases. Cancer Res. 58: 1225-30.
-
(1998)
Cancer Res.
, vol.58
, pp. 1225-1230
-
-
Nanni, P.1
Rossi, I.2
De Giovanni, C.3
Landuzzi, L.4
Nicoletti, G.5
Stoppacciaro, A.6
Parenza, M.7
-
40
-
-
0032996037
-
Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: Suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model
-
Nasu, Y., Bangma, C. H., Hull, G. W., Lee, H. M., Hu, J., Wang, J., McCurdy, M. A., et al. (1999) Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model. Gene Ther. 6: 338-49.
-
(1999)
Gene Ther.
, vol.6
, pp. 338-349
-
-
Nasu, Y.1
Bangma, C.H.2
Hull, G.W.3
Lee, H.M.4
Hu, J.5
Wang, J.6
McCurdy, M.A.7
-
41
-
-
0033566984
-
Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12
-
Nishioka, Y., Hirao, M., Robbins, P. D., Lotze, M. T. and Tahara, H. (1999) Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12. Cancer Res. 59: 4035-41.
-
(1999)
Cancer Res.
, vol.59
, pp. 4035-4041
-
-
Nishioka, Y.1
Hirao, M.2
Robbins, P.D.3
Lotze, M.T.4
Tahara, H.5
-
42
-
-
0035085442
-
Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity
-
Palmer, K., Hitt, M., Emtage, P. C., Gyorffy, S. and Gauldie, J. (2001) Combined CXC chemokine and interleukin-12 gene transfer enhances antitumor immunity. Gene Ther. 8: 282-90.
-
(2001)
Gene Ther.
, vol.8
, pp. 282-290
-
-
Palmer, K.1
Hitt, M.2
Emtage, P.C.3
Gyorffy, S.4
Gauldie, J.5
-
43
-
-
4143149590
-
A phase I study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: Analysis of sustained interferon gamma production in a subset of patients
-
Parihar, R., Nadella, P., Lewis, A., Jensen, R., De Hoff, C., Dierksheide, J. E., VanBuskirk, A. M., et al. (2004) A phase I study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: analysis of sustained interferon gamma production in a subset of patients. Clin. Cancer Res. 10: 5027-37.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 5027-5037
-
-
Parihar, R.1
Nadella, P.2
Lewis, A.3
Jensen, R.4
De Hoff, C.5
Dierksheide, J.E.6
VanBuskirk, A.M.7
-
44
-
-
0034031750
-
Construction of a recombinant adeno-associated virus (rAAV) vector expressing murine interleukin-12 (IL-12)
-
Paul, D., Qazilbash, M. H., Song, K., Xu, H., Sinha, B. K., Liu, J. and Cowan, K. H. (2000) Construction of a recombinant adeno-associated virus (rAAV) vector expressing murine interleukin-12 (IL-12) Cancer Gene Ther. 7: 308-15.
-
(2000)
Cancer Gene Ther.
, vol.7
, pp. 308-315
-
-
Paul, D.1
Qazilbash, M.H.2
Song, K.3
Xu, H.4
Sinha, B.K.5
Liu, J.6
Cowan, K.H.7
-
45
-
-
20444466384
-
Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients
-
(in press)
-
Peñuelas, I., Mazzolini, G., Boán, J. F., Sangro, B., Martí-Climent, J., Ruiz, M., Satyamurthy, N., et al. (2005) Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients. Gastroenterology (in press)
-
(2005)
Gastroenterology
-
-
Peñuelas, I.1
Mazzolini, G.2
Boán, J.F.3
Sangro, B.4
Martí-Climent, J.5
Ruiz, M.6
Satyamurthy, N.7
-
46
-
-
2342635773
-
Treatment of murine hepatocellular carcinoma using genetically modified cells to express interleukin-12
-
Peron, J. M., Couderc, B., Rochaix, P., Douin-Echinard, V., Asnacios, A., Souque, A., Voigt, J. J., et al. (2004) Treatment of murine hepatocellular carcinoma using genetically modified cells to express interleukin-12. J. Gastroenterol. Hepatol. 19: 388-96.
-
(2004)
J. Gastroenterol. Hepatol.
, vol.19
, pp. 388-396
-
-
Peron, J.M.1
Couderc, B.2
Rochaix, P.3
Douin-Echinard, V.4
Asnacios, A.5
Souque, A.6
Voigt, J.J.7
-
47
-
-
0032412286
-
Antimetastatic vaccination against Lewis lung carcinoma with autologous tumor cells modified to express murine interleukin 12
-
Popovic, D., El-Shami, K. M., Vadai, E., Feldman, M., Tzehoval, E. and Eisenbach, L. (1998) Antimetastatic vaccination against Lewis lung carcinoma with autologous tumor cells modified to express murine interleukin 12. Clin. Exp. Metastasis 16: 623-32.
-
(1998)
Clin. Exp. Metastasis
, vol.16
, pp. 623-632
-
-
Popovic, D.1
El-Shami, K.M.2
Vadai, E.3
Feldman, M.4
Tzehoval, E.5
Eisenbach, L.6
-
48
-
-
1642401096
-
Biologic therapy of liver tumors
-
Prieto, J., Qian, C., Sangro, B., Melero, I. and Mazzolini, G. (2004) Biologic therapy of liver tumors. Surg. Clin. North. Am. 84: 673-96.
-
(2004)
Surg. Clin. North. Am.
, vol.84
, pp. 673-696
-
-
Prieto, J.1
Qian, C.2
Sangro, B.3
Melero, I.4
Mazzolini, G.5
-
49
-
-
0035925568
-
Large nontransplanted hepatocellular carcinoma in woodchucks: Treatment with adenovirus-mediated delivery of interleukin 12/B7.1 genes
-
Putzer, B. M., Stiewe, T., Rodicker, F., Schildgen, O., Ruhm, S., Dirsch, O., Fiedler, M., et al. (2001) Large nontransplanted hepatocellular carcinoma in woodchucks: treatment with adenovirus-mediated delivery of interleukin 12/B7.1 genes. J. Natl. Cancer Inst. 93: 472-9.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 472-479
-
-
Putzer, B.M.1
Stiewe, T.2
Rodicker, F.3
Schildgen, O.4
Ruhm, S.5
Dirsch, O.6
Fiedler, M.7
-
50
-
-
0033162420
-
Construction and characterization of a recombinant adenoviral vector expressing human interleukin-12
-
Qiao, J., Chen, S. H., Pham-Nguyen, K. B., Mandeli, J. and Woo, S. L. (1999) Construction and characterization of a recombinant adenoviral vector expressing human interleukin-12. Cancer Gene Ther. 6: 373-9.
-
(1999)
Cancer Gene Ther.
, vol.6
, pp. 373-379
-
-
Qiao, J.1
Chen, S.H.2
Pham-Nguyen, K.B.3
Mandeli, J.4
Woo, S.L.5
-
51
-
-
0033054559
-
Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this "adaptive response" in mice
-
Rakhit, A., Yeon, M. M., Ferrante, J., Fettner, S., Nadeau, R., Motzer, R., Bukowski, R., et al. (1999) Down-regulation of the pharmacokinetic-pharmacodynamic response to interleukin-12 during long-term administration to patients with renal cell carcinoma and evaluation of the mechanism of this "adaptive response" in mice. Clin. Pharmacol. Ther. 65: 615-29.
-
(1999)
Clin. Pharmacol. Ther.
, vol.65
, pp. 615-629
-
-
Rakhit, A.1
Yeon, M.M.2
Ferrante, J.3
Fettner, S.4
Nadeau, R.5
Motzer, R.6
Bukowski, R.7
-
52
-
-
4444381878
-
Treatment of experimental breast cancer using interleukin-12 gene therapy combined with anti-vascular endothelial growth factor receptor-2 antibody
-
Rakhmilevich, A. L., Hooper, A. T., Hicklin, D. J. and Sondel, P. M. (2004) Treatment of experimental breast cancer using interleukin-12 gene therapy combined with anti-vascular endothelial growth factor receptor-2 antibody. Mol. Cancer Ther. 3: 969-76.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 969-976
-
-
Rakhmilevich, A.L.1
Hooper, A.T.2
Hicklin, D.J.3
Sondel, P.M.4
-
53
-
-
0036841570
-
Immunosuppressive effects of interleukin-12 coexpression in melanoma antigen gene-modified dendritic cell vaccines
-
Ribas, A., Amarnani, S. N., Buga, G. M., Butterfield, L. H., Dissette, V. B., McBride, W. H., Glaspy, J. A., et al. (2002) Immunosuppressive effects of interleukin-12 coexpression in melanoma antigen gene-modified dendritic cell vaccines. Cancer Gene Ther. 9: 875-83.
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 875-883
-
-
Ribas, A.1
Amarnani, S.N.2
Buga, G.M.3
Butterfield, L.H.4
Dissette, V.B.5
McBride, W.H.6
Glaspy, J.A.7
-
54
-
-
0031127020
-
Interleukin-12: Role of interferon-gamma in IL-12 adverse effects
-
Ryffel, B. (1997) Interleukin-12: role of interferon-gamma in IL-12 adverse effects. Clin. Immunol. Immunopathol. 83: 18-20.
-
(1997)
Clin. Immunol. Immunopathol.
, vol.83
, pp. 18-20
-
-
Ryffel, B.1
-
55
-
-
0030662705
-
Protective effect of a single interleukin-12 (IL-12) predose against the toxicity of subsequent chronic IL-12 in mice: Role of cytokines and glucocorticoids
-
Sacco, S., Heremans, H., Echtenacher, B., Buurman, W. A., Amraoui, Z., Goldman, M. and Ghezzi, P. (1997) Protective effect of a single interleukin-12 (IL-12) predose against the toxicity of subsequent chronic IL-12 in mice: role of cytokines and glucocorticoids. Blood 90: 4473-9.
-
(1997)
Blood
, vol.90
, pp. 4473-4479
-
-
Sacco, S.1
Heremans, H.2
Echtenacher, B.3
Buurman, W.A.4
Amraoui, Z.5
Goldman, M.6
Ghezzi, P.7
-
56
-
-
2342576353
-
Route of administration influences the antitumor effects of bone marrow-derived dendritic cells engineered to produce interleukin-12 in a metastatic mouse prostate cancer model
-
Saika, T., Satoh, T., Kusaka, N., Ebara, S., Mouraviev, V. B., Timme, T. L. and Thompson, T. C. (2004) Route of administration influences the antitumor effects of bone marrow-derived dendritic cells engineered to produce interleukin-12 in a metastatic mouse prostate cancer model. Cancer Gene Ther. 11: 317-24.
-
(2004)
Cancer Gene Ther.
, vol.11
, pp. 317-324
-
-
Saika, T.1
Satoh, T.2
Kusaka, N.3
Ebara, S.4
Mouraviev, V.B.5
Timme, T.L.6
Thompson, T.C.7
-
57
-
-
29444451219
-
Safety Issues of Interleukin 12 Gene Therapy using Adenoviral Vectors
-
Sangro, B., Gil, A., Díaz, L., Ruiz, J., Córdoba, M., Barajas, M., Bustos, M., et al. (2000) Safety Issues of Interleukin 12 Gene Therapy using Adenoviral Vectors. Mol. Ther. 1: S532.
-
(2000)
Mol. Ther.
, vol.1
-
-
Sangro, B.1
Gil, A.2
Díaz, L.3
Ruiz, J.4
Córdoba, M.5
Barajas, M.6
Bustos, M.7
-
58
-
-
2342570309
-
Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors
-
Sangro, B., Mazzolini, G., Ruiz, J., Herraiz, M., Quiroga, J., Herrero, I., Benito, A., et al. (2004) Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J. Clin. Oncol. 22: 1389-97.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1389-1397
-
-
Sangro, B.1
Mazzolini, G.2
Ruiz, J.3
Herraiz, M.4
Quiroga, J.5
Herrero, I.6
Benito, A.7
-
59
-
-
0033540621
-
Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA
-
Schultz, J., Pavlovic, J., Strack, B., Nawrath, M. and Moelling, K. (1999) Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA. Hum. Gene Ther. 10: 407-17.
-
(1999)
Hum. Gene Ther.
, vol.10
, pp. 407-417
-
-
Schultz, J.1
Pavlovic, J.2
Strack, B.3
Nawrath, M.4
Moelling, K.5
-
60
-
-
20244383435
-
The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice
-
Sunamura, M., Sun, L., Lozonschi, L., Duda, D. G., Kodama, T., Matsumoto, G., Shimamura, H., et al. (2000) The antiangiogenesis effect of interleukin 12 during early growth of human pancreatic cancer in SCID mice. Pancreas 20: 227-33.
-
(2000)
Pancreas
, vol.20
, pp. 227-233
-
-
Sunamura, M.1
Sun, L.2
Lozonschi, L.3
Duda, D.G.4
Kodama, T.5
Matsumoto, G.6
Shimamura, H.7
-
61
-
-
0036211620
-
Intratumoral delivery of adenovirus-mediated interleukin-12 gene in mice with metastatic cancer in the liver
-
Sung, M. W., Chen, S. H., Thung, S. N., Zhang, D. Y., Huang, T. G., Mandeli, J. P. and Woo, S. L. (2002) Intratumoral delivery of adenovirus-mediated interleukin-12 gene in mice with metastatic cancer in the liver. Hum. Gene Ther. 13: 731-43.
-
(2002)
Hum. Gene Ther.
, vol.13
, pp. 731-743
-
-
Sung, M.W.1
Chen, S.H.2
Thung, S.N.3
Zhang, D.Y.4
Huang, T.G.5
Mandeli, J.P.6
Woo, S.L.7
-
62
-
-
0027953555
-
Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in. vivo
-
Tahara, H., Zeh, H. J., 3rd, Storkus, W. J., Pappo, I., Watkins, S. C., Gubler, U., Wolf, S. F., et al. (1994) Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in. vivo. Cancer Res. 54: 182-9.
-
(1994)
Cancer Res.
, vol.54
, pp. 182-189
-
-
Tahara, H.1
Zeh III, H.J.2
Storkus, W.J.3
Pappo, I.4
Watkins, S.C.5
Gubler, U.6
Wolf, S.F.7
-
63
-
-
11144356776
-
Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens
-
Tirapu, I., Arina, A., Mazzolini, G., Duarte, M., Alfaro, C., Feijoo, E., Qian, C., et al. (2004) Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens. Int. J. Cancer 110: 51-60.
-
(2004)
Int. J. Cancer
, vol.110
, pp. 51-60
-
-
Tirapu, I.1
Arina, A.2
Mazzolini, G.3
Duarte, M.4
Alfaro, C.5
Feijoo, E.6
Qian, C.7
-
64
-
-
0347991866
-
Prolonged and inducible transgene expression in the liver using gutless adenovirus: A potential therapy for liver cancer
-
Wang, L., Hernandez-Alcoceba, R., Shankar, V., Zabala, M., Kochanek, S., Sangro, B., Kramer, M. G., et al. (2004) Prolonged and inducible transgene expression in the liver using gutless adenovirus: a potential therapy for liver cancer. Gastroenterology 126: 278-89.
-
(2004)
Gastroenterology
, vol.126
, pp. 278-289
-
-
Wang, L.1
Hernandez-Alcoceba, R.2
Shankar, V.3
Zabala, M.4
Kochanek, S.5
Sangro, B.6
Kramer, M.G.7
-
65
-
-
3042770658
-
Angiogenesis inhibition by an oncolytic herpes virus expressing interleukin 12
-
Wong, R. J., Chan, M. K., Yu, Z., Ghossein, R. A., Ngai, I., Adusumilli, P. S., Stiles, B. M., et al. (2004) Angiogenesis inhibition by an oncolytic herpes virus expressing interleukin 12. Clin. Cancer Res. 10: 4509-16.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 4509-4516
-
-
Wong, R.J.1
Chan, M.K.2
Yu, Z.3
Ghossein, R.A.4
Ngai, I.5
Adusumilli, P.S.6
Stiles, B.M.7
-
66
-
-
1642535483
-
Effective intravenous therapy of murine pulmonary metastases with an oncolytic herpes virus expressing interleukin 12
-
Wong, R. J., Chan, M. K., Yu, Z., Kim, T. H., Bhargava, A., Stiles, B. M., Horsburgh, B. C., et al. (2004) Effective intravenous therapy of murine pulmonary metastases with an oncolytic herpes virus expressing interleukin 12. Clin. Cancer Res. 10: 251-9.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 251-259
-
-
Wong, R.J.1
Chan, M.K.2
Yu, Z.3
Kim, T.H.4
Bhargava, A.5
Stiles, B.M.6
Horsburgh, B.C.7
-
67
-
-
3142742769
-
Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors
-
Zabala, M., Wang, L., Hernandez-Alcoceba, R., Hillen, W., Qian, C., Prieto, J. and Kramer, M. G. (2004) Optimization of the Tet-on system to regulate interleukin 12 expression in the liver for the treatment of hepatic tumors. Cancer Res. 64: 2799-804.
-
(2004)
Cancer Res.
, vol.64
, pp. 2799-2804
-
-
Zabala, M.1
Wang, L.2
Hernandez-Alcoceba, R.3
Hillen, W.4
Qian, C.5
Prieto, J.6
Kramer, M.G.7
-
68
-
-
0037388549
-
Gene therapy of a rat follicular thyroid carcinoma model with adenoviral vectors transducing murine interleukin-12
-
Zhang, R. and DeGroot, L. J. (2003) Gene therapy of a rat follicular thyroid carcinoma model with adenoviral vectors transducing murine interleukin-12. Endocrinology 144: 1393-8.
-
(2003)
Endocrinology
, vol.144
, pp. 1393-1398
-
-
Zhang, R.1
DeGroot, L.J.2
-
69
-
-
0037530343
-
Continuous release of interleukin 12 from microencapsulated engineered cells for colon cancer therapy
-
Zheng, S., Xiao, Z. X., Pan, Y. L., Han, M. Y. and Dong, Q. (2003) Continuous release of interleukin 12 from microencapsulated engineered cells for colon cancer therapy. World J. Gastroenterol. 9: 951-5.
-
(2003)
World J. Gastroenterol.
, vol.9
, pp. 951-955
-
-
Zheng, S.1
Xiao, Z.X.2
Pan, Y.L.3
Han, M.Y.4
Dong, Q.5
-
70
-
-
0028625325
-
Construction and characterization of retroviral vectors expressing biologically active human interleukin-12
-
Zitvogel, L., Tahara, H., Cai, Q., Storkus, W. J., Muller, G., Wolf, S. F., Gately, M., et al. (1994) Construction and characterization of retroviral vectors expressing biologically active human interleukin-12. Hum. Gene Ther. 5: 1493-506.
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 1493-1506
-
-
Zitvogel, L.1
Tahara, H.2
Cai, Q.3
Storkus, W.J.4
Muller, G.5
Wolf, S.F.6
Gately, M.7
-
71
-
-
16844379997
-
Immunosuppressive networks in the tumour environment and their therapeutic relevance
-
Zou, W. (2005) Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat. Rev. Cancer 5: 263-74.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 263-274
-
-
Zou, W.1
|