Chlorthalidone improves endothelial-mediated vascular responses in hypertension complicated by nondiabetic metabolic syndrome

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 10, Issue 4, 2005, Pages 265-272

  Dell'Omo, Giulia ^a   Penno, Giuseppe ^a   Del Prato, Stefano ^a   Pedrinelli, Roberto ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Chlorthalidone; Endothelial function; Essential hypertension; Metabolic syndrome

Indexed keywords

ACETYLCHOLINE; ALBUMIN I 125; CHLORTALIDONE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITROPRUSSIDE SODIUM; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL; BLOOD VESSEL REACTIVITY; CAPILLARY PERMEABILITY; CLINICAL ARTICLE; COLORIMETRY; CONTROLLED STUDY; FOLLOW UP; FOREARM BLOOD FLOW; HEMODYNAMICS; HOMEOSTASIS; HUMAN; HYPERTENSION; IMMUNORADIOMETRIC ASSAY; INSULIN SENSITIVITY; MALE; METABOLIC SYNDROME X; ORAL GLUCOSE TOLERANCE TEST; PLETHYSMOGRAPHY; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE; VASODILATATION; VASOMOTOR REFLEX;

ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CAPILLARIES; CHLORTHALIDONE; DIURETICS; ENDOTHELIUM, VASCULAR; FOREARM; HUMANS; HYPERTENSION; MALE; METABOLIC SYNDROME X; MIDDLE AGED; SERUM ALBUMIN; VASCULAR RESISTANCE; VASODILATION;

EID: 29344472591     PISSN: 10742484     EISSN: None     Source Type: Journal    
DOI: 10.1177/107424840501000406     Document Type: Article

References (44)

1. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285:2486-2497, 2001
2. Park YW, Zhu S, Palaniappan L, et al. The metabolic syndrome: Prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 163:427-436, 2003
3. Sattar N, Gaw A, Scherbakova O, Ford I, et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 108:414-419, 2003
4. Dell'Omo G, Penno G, Del Prato S, et al. Abnormal capillary permeability and endothelial dysfunction in hypertension with comorbid Metabolic Syndrome. Atherosclerosis 172:383-389, 2004
5. Anderson TJ. Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction. Heart Fail Rev 8:71-86, 2003
6. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 104:191-196, 2001
7. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. JAMA 289:2560-2572, 2003
8. Schiffrin EL. Vascular remodeling and endothelial function in hypertensive patients: Effects of antihypertensive therapy. Scand Cardiovasc J (Suppl) 47:15-21, 1998
9. Higashi Y, Sasaki S, Nakagawa K, et al. A comparison of angiotensin-converting enzyme inhibitors, calcium antagonists, beta-blockers and diuretic agents on reactive hyperemia in patients with essential hypertension: A multicenter study. J Am Coll Cardiol 35:284-291, 2000
10. Klingbeil AU, John S, Schneider MP, et al. Effect of AT1 receptor blockade on endothelial function in essential hypertension. Am J Hypertens 16:123-128, 2003
11. Chung NA, Beevers DG, Lip G. Effects of losartan versus hydrochlorothiazide on indices of endothelial damage/dysfunction, angiogenesis and tissue factor in essential hypertension. Blood Press 13:183-189, 2004
12. Carter BL, Ernst ME, Cohen JD. Hydrochlorothiazide versus chlorthalidone: Evidence supporting their interchangeability. Hypertension 43:4-9, 2004
13. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288:373-376, 1980
14. Bohme E, Graf H, Schultz G. Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP-formation in smooth muscle and platelets. Adv Cyclic Nucleotide Res 9:131-143, 1978
15. Folkow B. Physiological aspects of primary hypertension. Physiol Rev 62:347-504, 1982
16. Parving HH. Microvascular permeability to plasma proteins in hypertension and diabetes mellitus in man-on the pathogenesis of hypertensive and diabetic microangiopathy. Dan Med Bull 22:217-233, 1975
17. Padwal R, Laupacis A. Antihypertensive therapy and incidence of type 2 diabetes: A systematic review. Diabetes Care 27:247-255, 2004
18. Dell'Omo G, Bandinelli S, Penno G, et al. Simvastatin, capillary permeability and acetylcholine-mediated vasomotion in atherosclerotic, hypercholesterolemic men. Clin Pharmacol Ther 68:427-434, 2000
19. Pedrinelli R, Spessot M, Salvetti A. Reactive hyperemia during short-term blood flow and pressure changes in the hypertensive forearm. J Hypertens 8:467-471, 1990
20. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28:412-419, 1985
21. Bissoli NS, Vasquez EC, Cabrai AM. Chlorthalidone-modulated vascular responses to vasodilator stimuli in DOCA-salt hypertensive rats. Pharmacol Res 33:47-54, 1996
22. Rosenthal T, Holtzman E, Segal P. The effect of chlorthalidone on serum lipids and lipoproteins. Atherosclerosis 36:111-115, 1980
23. Stroes ES, Koomans HA, de Bruin TW et al. Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet 346:467-471, 1995
24. Wheatcroft SB, Williams IL, Shah AM, et al. Pathophysiological implications of insulin resistance on vascular endothelial function. Diabet Med 20:255-268, 2003
25. Pickkers P, Garcha RS, Schachter M, et al. Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide. Hypertension 33:1043-1048, 1999
26. Zhu Z, Zhu S, Liu D, et al. Thiazide-like diuretics attenuate agonist-induced vasoconstriction by calcium desensitization linked to rho kinase. Hypertension 45:233-239, 2005
27. Colas B, Slama M, Collin T, et al. Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol 408:63-67, 2000
28. Colas B, Slama M, Masson H, et al. Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats. Fundam Clin Pharmacol 14:363-368, 2000
29. Bragulat E, de la Sierra A. Salt intake, endothelial dysfunction, and salt-sensitive hypertension. J Clin Hypertens (Greenwich) 4:41-46, 2002
30. Boegehold MA. Flow-dependent arteriolar dilation in normotensive rats fed low or high-salt diets. Am J Physiol Heart Circ Physiol 269:H1407-H1414, 1995
31. Fujita T, Ito Y. Salt loads attenuate potassium-induced vasodilation of forearm vasculature in humans. Hypertension 21:772-778, 1993
32. Dakak N, Husain S, Mulcahy D, et al. Contribution of nitric oxide to reactive hyperemia. Impact of endothelial dysfunction. Hypertension 32:9-15, 1998
33. Dell'Omo G, Penno G, Pucci L, et al. The vascular effects of doxazosin in hypertension with metabolic syndrome. Coron Artery Dis 16:67-73, 2005
34. Park JB, Schiffrin EL. Effects of antihypertensive therapy on hypertensive vascular disease. Curr Hypertens Rep 2:280-288, 2000
35. Freslon JL, Giudicelli JF. Compared myocardial and vascular effects of captopril and dihydralazine during hypertension development in spontaneously hypertensive rats. Br J Pharmac 80:533-543, 1983
36. Korner PI. Cardiovascular hypertrophy and hypertension: causes and consequences. Blood Press Suppl 2:6-16, 1995
37. Sivertsson R, Hansson L. Effects of blood pressure reduction on the structural vascular abnormality in skin and muscle vascular beds in human essential hypertension. Clin Sci Mol Med (Suppl) 3:77s-79s, 1976
38. Nielsen FS, Rossing P, Gall MA, et al. Lisinopril improves endothelial dysfunction in hypertensive NIDDM subjects with diabetic nephropathy. Scand J Clin Lab Invest 57:427-434, 1997
39. Parving HH, Kastrup J, Smidt UM. Reduced transcapillary escape of albumin during acute blood pressure-lowering in type 1 (insulin-dependent) diabetic patients with nephropathy. Diabetologia 28:797-801, 1985
40. Hesse B, Parving HH, Lund-Jacobsen H, et al. Transcapillary escape rate of albumin and right atrial pressure in chronic congestive heart failure before and after treatment. Circ Res 39:358-362, 1976
41. Reisin E, Weir MR, Falkner B, et al. Lisinopril versus hydrochlorothiazide in obese hypertensive patients: A multicenter placebo-controlled trial. Treatment in Obese Patients With Hypertension (TROPHY) Study Group. Hypertension 30:140-145, 1997
42. Grassi G, Seravalle G, Dell'Oro R, et al; CROSS Study. Comparative effects of candesartan and hydrochlorothiazide on blood pressure, insulin sensitivity, and sympathetic drive in obese hypertensive individuals: Results of the CROSS study. J Hypertens 221:1761-1769, 2003
43. Fletcher A, Amery A, Birkenhager W, et al. Risks and benefits in the trial of the European Working Party on High Blood Pressure in the Elderly. J Hypertens 9:225-230, 1991
44. Savage PH, Pressel SL, Curb D, et al. Influence of long-term, low-dose, diuretic-based antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension. Arch Intern Med 158:741-751, 1998