Kaempferol inhibits apoptosis in vascular smooth muscle induced by a component of oxidized LDL

European Journal of Pharmacology

Volumn 529, Issue 1-3, 2006, Pages 79-83

  Ruiz, Emilio ^a   Padilla, Eugenia ^a   Redondo, Santiago ^a   Gordillo Moscoso, Antonio ^a   Tejerina, Teresa ^a  

^a SCHOOL OF MEDICINE   (Spain)

Author keywords

7 hydroxycholesterol; Apoptosis; Kaempferol; Vascular smooth muscle

Indexed keywords

7BETA HYDROXYCHOLESTEROL; CASPASE 3; DNA FRAGMENT; ESTROGEN RECEPTOR ALPHA; FLAVONOID; FULVESTRANT; KAEMPFEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN BCL XL; RECEPTOR BLOCKING AGENT; RUTOSIDE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; RED WINE; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; APOPTOSIS; BCL-X PROTEIN; CELLS, CULTURED; ESTROGEN RECEPTOR ALPHA; HYDROXYCHOLESTEROLS; KAEMPFEROLS; LIPOPROTEINS, LDL; MALE; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, WISTAR; RUTIN;

EID: 29344455162     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.10.061     Document Type: Article

References (29)

1. M.R. Bennett, G.I. Evan, and A.C. Newby Deregulated expression of the c-myc oncogene abolishes inhibition of proliferation of rat vascular smooth muscle cells by serum reduction, interferon-γ, heparin, and cyclic nucleotide analogues and induces apoptosis Circ. Res. 74 1994 525 536
2. M.R. Bennett, G.I. Evan, and S.M. Schwartz Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques J. Clin. Invest. 95 1995 2266 2274
3. J.A. Berliner, and J.W. Heinecke The role of oxidized lipoproteins in atherogenesis Free Radic. Biol. Med. 20 1996 707 727
4. J. Burns, P. Gardner, J. O'Neill, S. Crawford, I. Morecroft, D. McPhail, C. Lister, D. Matthews, M. McLean, M. Lean, G. Duthie, and A. Crozier Relationship among antioxidant activity, vasodilation capacity, and phenolic content of red wines J. Agric. Food Chem. 48 2000 20 230
5. G.M. Chisolm, G. Ma, K.C. Irwin, L.L. Martin, K.G. Gunderson, L.F. Linberg, D.W. Morel, and P.E. DiCorleto 7β-Hydroperoxycholest-5-en-3β- ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein Proc. Natl. Acad. Sci. U. S. A. 91 1994 11452 11456
6. Y.J. Choi, J.S. Kang, J.H. Park, Y.J. Lee, J.S. Choi, and Y.H. Kang Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide-treated human vascular endothelial cells J. Nutr. 133 2003 985 991
7. P. Colburn, and V. Buonassisi Estrogen-binding sites in endothelial cell cultures Science 201 1978 817 819
8. G.A. Colditz, W.C. Willoett, M. Stampfer, B. Rosner, F.E. Speizer, and C.H. Hennekens Menopause and the risk of coronary heart disease in women N. Engl. J. Med. 316 1987 1105 1110
9. R.J. Cook, and V.T. Farewell Multiplicity consideration in the design and analysis of clinical trials J. R. Stat. Soc. 159 1996 93 110
10. W. Greenrod, and M. Fenech The principal phenolic and alcoholic components of wine protect human lymphocytes against hydrogen peroxide- and ionizing radiation-induced DNA damage in vitro Mutagenesis 18 2003 119 126
11. H. Hughes, B. Mathews, M.L. Lenz, and J.R. Guyton Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol Arterioscler. Thromb. Vasc. Biol. 14 1994 1177 1185
12. J.-H. Jang, and Y.-J. Surh Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells Mutat. Res. 496 2001 181 190
13. J. Kotani, G.S. Mintz, M.T. Castagna, E. Pinnow, C.O. Berzingi, A.B. Bui, A.D. Pichard, L.F. Satler, W.O. Suddath, R. Waksman, J.R. Laird, K.M. Kent, and N.J. Weissman Intravascular ultrasound analysis of infarct-related and non-infarct-related arteries in patients who presented with an acute myocardial infarction Circulation 107 2003 2889 2893
14. J. Li, W. Li, J. Su, W. Liu, B.T. Altura, and B.M. Altura Hydrogen peroxide induces apoptosis in cerebral vascular smooth muscle cells: possible relation to neurodegenerative diseases and strokes Brain Res. Bull. 62 2003 101 106
15. G. Lizard, S. Gueldry, O. Sordet, S. Monier, A. Athias, C. Miguet, G. Bessede, S. Lemaire, E. Solary, and P. Gambert Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production FASEB J. 12 1998 1651 1663
16. G. Lizard, C. Miguet, G. Besséde, S. Monier, S. Gueldry, D. Neel, and P. Gambert Impairment with various antioxidants of the loss of mitochondrial transmembrane potential and of the cytosolic release of cytochrome c occuring during 7-ketocholesterol-induced apoptosis Free Radic. Biol. Med. 28 2000 743 753
17. A.J. Minn, L.H. Boise, and C.B. Thompson Bcl-x(S) anatagonizes the protective effects of Bcl-x(L) J. Biol. Chem. 271 1996 6306 6312
18. M.J. Mitchinson, S.J. Hardwick, and M.R. Bennett Cell death in atherosclerotic plaques Curr. Opin. Lipidol. 7 1996 324 329
19. E. Nishio, and Y. Watanabe Oxysterols induced apoptosis in cultured smooth muscle cells through CPP32 protease activation and bcl-2 protein downregulation Biochem. Biophys. Res. Commun. 226 1996 928 934
20. E. Padilla, E. Ruiz, S. Redondo, A. Gordillo-Moscoso, K. Slowing, and T. Tejerina Relationship between vasodilation capacity and phenolic content of Spanish wines Eur. J. Pharmacol. 517 2005 84 91
21. A. Orimo, S. Inoue, A. Ikegami, T. Hosoi, M. Akishita, Y. Ouchi, M.O. Muramatsu, and H. Orimo Vascular smooth muscle cells as target for estrogen Biochem. Biophys. Res. Commun. 195 1993 730 736
22. W. Palinski, M.E. Rosenfeld, S. Yla-Herttuala, G.C. Gurtner, S.S. Socher, S.W. Butler, S. Parthasarathy, T.E. Carew, D. Steinberg, and J.L. Witztum Low density lipoprotein undergoes oxidative modification in vivo Proc. Natl. Acad. Sci. U. S. A. 86 1989 1372 1376
23. A.G. Porter, and R.U. Jänicke Emerging role of caspase-3 in apoptosis Cell Death Differ. 6 1999 99 104
24. H. Schroeter, J.P. Spencer, C. Rice-Evans, and R.J. Williams Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3 Biochem. J. 358 2001 547 557
25. R.C. Sharma, D.W. Crawford, D. Kramsch, A. Sevanian, and Q. Jiao Immunolocalization of native antioxidant scavenger enzymes in early hypertensive and atherosclerotic arteries: role of oxygen free radicals Arterioscler. Thromb. 12 1992 403 415
26. R.C. Siow, J.P. Richards, K.C. Pedley, D.S. Leake, and G.E. Mann Vitamin C protects human vascular smooth muscle cells against apoptosis induced by moderately oxidized LDL containing high levels of lipid hydroperoxides Arterioscler. Thromb. Vasc. Biol. 19 1999 2387 2394
27. N. Sudoh, K. Toba, M. Akishita, J. Ako, M. Hashimoto, K. Iijima, S. Kim, Y.Q. Liang, Y. Ohike, T. Watanabe, I. Yamazaki, M. Yoshizumi, M. Eto, and Y. Ouchi Estrogen prevents oxidative stress-induced endothelial cell apoptosis in rats Circulation 103 2001 724 729
28. I.K. Wang, S.Y. Lin-Shiau, and J.K. Lin Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells Eur. J. Cancer 35 1999 1517 1525
29. A. Wattel, S. Kamel, R. Mentaverri, F. Lorget, C. Prouillet, J.P. Petit, P. Fardelonne, and M. Brazier Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone reabsorption Biochem. Pharmacol. 65 2003 34 42