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The hydrophobic nature of fluorinated compounds often causes improved transport across the blood brain barrier. Improved oral bioavailability is seen in some systems where fluorine substitution leads to improved hydrolytic stability. Furthermore, replacement of sensitive or reactive groups such as C-OH, C-H, and C=O with fluorinated substituents has led to mechanism-based inhibitors for a wide variety of diseases and to chemotherapeutic drugs.
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Thus, molecular dynamics simulations on mixtures involving water, hydrocarbons, and a variety of fluorinated molecules are currently carried out with the purpose of understanding the nature of the fluorous phase and to establish what kind of intermolecular forces can explain the formation of different phases at the University of Wisconsin at Madison by Professor Sandro Mecozzi's research group. S. Mecozzi, personal communication (March 2005).
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note
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2 marketed in the US since 1995 by Micell Technologies in partnership with the Hangers chain of dry cleaners (with stores using the technology in the US, Canada and two EU member States as of March 2005).
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72
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0003438585
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Little Brown and Company, New York
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This refers to a new management approach to the environmental issues started in the mid 1980s with environmental certification programs such as Responsible Care, ISO 14001 and Emas, and evolved into the concept of sustainability as a central issue to be managed at the board level aiming at Zero Emissions performance level. See also: P. Hawken, A. Lovins and L. H. Lovins, Natural Capitalism: Creating the Next Industrial Revolution, Little Brown and Company, New York, 1999.
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Natural Capitalism: Creating the next Industrial Revolution
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P. Wang, S. M. Zakeeruddin, J. E. Moser, M. K. Nazeeruddin, T. Sekiguchi and M. Grätzel, Nat. Mater., 2003, 2, 402.
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Grätzel, M.6
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