Synthetic approaches to nuclease-resistant, nonnatural dinucleotides of anti-HIV integrase interest

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 10-12, 2005, Pages 1449-1468

  Chi, Guochen ^a   Nair, Vasu ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Exonuclease; HIV integrase; Inhibitors; Phosphorylation; Synthesis

Indexed keywords

1' DEOXY 2' ISOADENYLYL (3'-5') 1' DEOXY 2' DEOXYADENOSINE; 1' DEOXY 2' ISOADENYLYL (3'-5') 1' DEOXY 2' ISOCYTIDINE; 1' DEOXY 2' ISOADENYLYL (3'-5') CYTIDINE; 1' DEOXY 2' ISOADENYLYL (3'-5') URIDINE; 2' DEOXYADENYLYL (3'-5') 1' DEOXY 2' ISOADENOSINE; 2' DEOXYADENYLYL (3'-5') 1' DEOXY 2' ISOCYTIDINE; 5' O ETHOXYPHOSPHONYL 1' DEOXY 2' ISOADENYLYL (3'-5') CYTIDINE; 5' O PHOSPHORYL 1' DEOXY 2' ISOADENYLYL (3'-5') 1' DEOXY 2' ISOCYTIDINE; 5' O PHOSPHORYL 1' DEOXY 2' ISOADENYLYL (3'-5') 2' DEOXYADENOSINE; 5' O PHOSPHORYL 1' DEOXY 2' ISOADENYLYL (3'-5') CYTIDINE; 5' O PHOSPHORYL 1' DEOXY 2' ISOADENYLYL (3'-5') URIDINE; 5' O PHOSPHORYL 2' DEOXYADENYLYL (3'-5') 1' DEOXY 2' ISOADENOSINE; 5' O PHOSPHORYL 2' DEOXYADENYLYL (3'-5') 1' DEOXY 2' ISOCYTIDINE; 5' O PHOSPHORYL 2' DEOXYADENYLYL (3'-5') 1',3' DIDEOXY 2' ISOADENOSINE; 5' O PHOSPHORYL 2' DEOXYCYTIDYL (3'-5') 1' DEOXY 2' ISOTHYMIDINE; 5' O PHOSPHORYL 2' DEOXYCYTIDYL (3'-5') 1' DEOXY 2' ISOURIDINE; 6 N BENZOYL 4 (2 CYANOETHYL) 1' DEOXY 2' ISOADENYLYL (3'-5') 3 N,2' O,3' O TRIBENZOYLURIDINE; 6 N BENZOYL 4 (2 CYANOETHYL) 1' DEOXY 2' ISOADENYLYL (3'-5') 4 N,2' O,3' O TRIBENZOYLCYTIDINE; 6 N BENZOYL 4 (2 CYANOETHYL) 1' DEOXY 2' ISOADENYLYL (3'-5') 4 N,3' O DIBENZOYL 1' DEOXY 2' ISOCYTIDINE; 6 N BENZOYL 4 (2 CYANOETHYL) 1' DEOXY 2' ISOADENYLYL (3'-5') 6 N,3' O DIBENZOYL 2' DEOXYADENOSINE; 6 N BENZOYL 4 (2 CYANOETHYL) 2' DEOXYADENYLYL (3'-5') 4 N,3' O DIBENZOYL 1' DEOXY 2' ISOCYTIDINE; 6 N BENZOYL 4 (2 CYANOETHYL) 2' DEOXYADENYLYL (3'-5') 6 N BENZOYL 1',3' DIDEOXY 2' ISOADENOSINE; 6 N BENZOYL 4 (2 CYANOETHYL) 2' DEOXYADENYLYL (3'-5') 6 N,3' O DIBENZOYL 1' DEOXY 2' ISOADENOSINE; 6 N BENZOYL 5' O [BIS(2 CYANOETHOXY)PHOSPHINYL] 4 (2 CYANOETHYL) 1' DEOXY 2' ISOADENYLYL (3'-5') 4 N,3' O DIBENZOYL 1' DEOXY 2' ISOCYTIDINE; 6 N BENZOYL 5' O [BIS(2 CYANOETHOXY)PHOSPHINYL] 4 (2 CYANOETHYL) 2' DEOXADENYLYL (3'-5') 4 N,3' O DIBENZOYL 1' DEOXY 2' ISOCYTIDINE; 6 N BENZOYL 5' O [BIS(2 CYANOETHOXY)PHOSPHINYL] 4 (2 CYANOETHYL) 2' DEOXADENYLYL (3'-5') 6 N,3' O DIBENZOYL 1' DEOXY 2' ISODENOSINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DINUCLEOTIDE; EXONUCLEASE; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIVIRAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DEOXYRIBONUCLEASES; DINUCLEOSIDE PHOSPHATES; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; MOLECULAR STRUCTURE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 29244443692     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770500265703     Document Type: Article

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