-
1
-
-
0028883828
-
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland coronary prevention study group
-
J. Shepherd, S.M. Cobbe, I. Ford, C.G. Isles, A.R. Lorimer, P.W. MacFarlane, J.H. McKillop, and C.J. Packard Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland coronary prevention study group New Engl. J. Med. 333 1995 1301 1307
-
(1995)
New Engl. J. Med.
, vol.333
, pp. 1301-1307
-
-
Shepherd, J.1
Cobbe, S.M.2
Ford, I.3
Isles, C.G.4
Lorimer, A.R.5
MacFarlane, P.W.6
McKillop, J.H.7
Packard, C.J.8
-
2
-
-
0023876839
-
HMG-CoA reductase inhibitors for treatment of hypercholesterolemia
-
S.M. Grundy HMG-CoA reductase inhibitors for treatment of hypercholesterolemia New Engl. J. Med. 319 1988 24 33
-
(1988)
New Engl. J. Med.
, vol.319
, pp. 24-33
-
-
Grundy, S.M.1
-
3
-
-
0035843962
-
Structural mechanism for statin inhibition of HMG-CoA reductase
-
E.S. Istvan, and J. Deisenhofer Structural mechanism for statin inhibition of HMG-CoA reductase Science 292 2001 1160 1164
-
(2001)
Science
, vol.292
, pp. 1160-1164
-
-
Istvan, E.S.1
Deisenhofer, J.2
-
4
-
-
0022549920
-
A receptor-mediated pathway for cholesterol homeostasis
-
M.S. Brown, and J.L. Goldstein A receptor-mediated pathway for cholesterol homeostasis Science 232 1986 34 47
-
(1986)
Science
, vol.232
, pp. 34-47
-
-
Brown, M.S.1
Goldstein, J.L.2
-
6
-
-
0034821958
-
Rhabdomyolysis and HMG-CoA reductase inhibitors
-
M.A. Omar, J.P. Wilson, and T.S. Cox Rhabdomyolysis and HMG-CoA reductase inhibitors Ann. Pharmacother. 35 2001 1096 1107
-
(2001)
Ann. Pharmacother.
, vol.35
, pp. 1096-1107
-
-
Omar, M.A.1
Wilson, J.P.2
Cox, T.S.3
-
7
-
-
0013301537
-
Statin-fibrate combination: Therapy for hyperlipidemia: A review
-
A.S. Wierzbicki, D.P. Mikhailidis, R. Wray, M. Schacter, R. Cramb, W.G. Simpson, and C.B. Byrne Statin-fibrate combination: therapy for hyperlipidemia: a review Curr. Med. Res. Opin. 19 2003 155 168
-
(2003)
Curr. Med. Res. Opin.
, vol.19
, pp. 155-168
-
-
Wierzbicki, A.S.1
Mikhailidis, D.P.2
Wray, R.3
Schacter, M.4
Cramb, R.5
Simpson, W.G.6
Byrne, C.B.7
-
8
-
-
0026784960
-
Hypolipidemic effect of ethyl all-cis-5,8,11,14,17-eicosapentaenoate (EPA-E) in rats
-
K. Mizuguchi, T. Yano, M. Kojima, Y. Tanaka, M. Ishibashi, A. Masada, M. Sato, M. Mizota, K. Fukutake, and Y. Saito Hypolipidemic effect of ethyl all-cis-5,8,11,14,17-eicosapentaenoate (EPA-E) in rats Jpn. J. Pharmacol. 59 1992 307 312
-
(1992)
Jpn. J. Pharmacol.
, vol.59
, pp. 307-312
-
-
Mizuguchi, K.1
Yano, T.2
Kojima, M.3
Tanaka, Y.4
Ishibashi, M.5
Masada, A.6
Sato, M.7
Mizota, M.8
Fukutake, K.9
Saito, Y.10
-
9
-
-
0027475231
-
Mechanism of the lipid-lowering effect of ethyl all-cis-5,8,11,14,17- icosapentaenoate
-
K. Mizuguchi, T. Yano, Y. Tanaka, M. Ishibashi, A. Masada, M. Mizota, K. Fukutake, and Y. Saito Mechanism of the lipid-lowering effect of ethyl all-cis-5,8,11,14,17-icosapentaenoate Eur. J. Pharmacol. 231 1993 121 127
-
(1993)
Eur. J. Pharmacol.
, vol.231
, pp. 121-127
-
-
Mizuguchi, K.1
Yano, T.2
Tanaka, Y.3
Ishibashi, M.4
Masada, A.5
Mizota, M.6
Fukutake, K.7
Saito, Y.8
-
10
-
-
0027177233
-
Effects of highly purified ethyl all-cis-5,8,11,14,17-icosapentaenoate (EPA-E) on rabbit platelets
-
M. Sato, Y. Katsuki, K. Fukuhara, H. Kawano, M. Mizota, Y. Hamada, and Y. Kunihiro Effects of highly purified ethyl all-cis-5,8,11,14,17-icosapentaenoate (EPA-E) on rabbit platelets Biol. Pharm. Bull 16 1993 362 367
-
(1993)
Biol. Pharm. Bull
, vol.16
, pp. 362-367
-
-
Sato, M.1
Katsuki, Y.2
Fukuhara, K.3
Kawano, H.4
Mizota, M.5
Hamada, Y.6
Kunihiro, Y.7
-
11
-
-
0027270320
-
Ethyl all-cis-5,8,11,14,17-icosapentaenoate modifies the biochemical properties of rat very low-density lipoprotein
-
K. Mizuguchi, T. Yano, M. Ishibashi, A. Masada, M. Mizota, and Y. Saito Ethyl all-cis-5,8,11,14,17-icosapentaenoate modifies the biochemical properties of rat very low-density lipoprotein Eur. J. Pharmacol. 235 1993 221 227
-
(1993)
Eur. J. Pharmacol.
, vol.235
, pp. 221-227
-
-
Mizuguchi, K.1
Yano, T.2
Ishibashi, M.3
Masada, A.4
Mizota, M.5
Saito, Y.6
-
12
-
-
0027173369
-
Effects of ethyl all-cis-5,8,11,14,17-icosapentaenoate on the physical properties of arterial walls in high cholesterol diet-fed rabbits
-
M. Sato, Y. Katsuki, H. Kanehiro, M. Iimura, Y. Akada, M. Mizota, and Y. Kunihiro Effects of ethyl all-cis-5,8,11,14,17-icosapentaenoate on the physical properties of arterial walls in high cholesterol diet-fed rabbits J. Cardiovasc. Pharmacol. 22 1993 1 9
-
(1993)
J. Cardiovasc. Pharmacol.
, vol.22
, pp. 1-9
-
-
Sato, M.1
Katsuki, Y.2
Kanehiro, H.3
Iimura, M.4
Akada, Y.5
Mizota, M.6
Kunihiro, Y.7
-
13
-
-
0030812685
-
Effects of ethyl-all-cis-5,8,11,14,17-icosapentaenoate (EPA-E), pravastatin and their combination on serum lipids and intimal thickening of cuff-sheathed carotid artery in rabbits
-
T. Yano, H. Kawano, M. Yamashita, K. Mizuguchi, H. Mochizuki, and T. Iwamoto Effects of ethyl-all-cis-5,8,11,14,17-icosapentaenoate (EPA-E), pravastatin and their combination on serum lipids and intimal thickening of cuff-sheathed carotid artery in rabbits Life Sci. 61 1997 2007 2015
-
(1997)
Life Sci.
, vol.61
, pp. 2007-2015
-
-
Yano, T.1
Kawano, H.2
Yamashita, M.3
Mizuguchi, K.4
Mochizuki, H.5
Iwamoto, T.6
-
14
-
-
0029554459
-
Potential risk of myopathy by HMG-CoA reductase inhibitors: A comparison of pravastatin and simvastatin effects on membrane electrical properties of rat skeletal muscle fibers
-
S. Pierno, A. De Luca, D. Tricarico, A. Roselli, F. Natuzzi, E. Ferrannini, M. Laico, and D.C. Camerino Potential risk of myopathy by HMG-CoA reductase inhibitors: a comparison of pravastatin and simvastatin effects on membrane electrical properties of rat skeletal muscle fibers J. Pharmacol. Exp. Ther. 275 1995 1490 1496
-
(1995)
J. Pharmacol. Exp. Ther.
, vol.275
, pp. 1490-1496
-
-
Pierno, S.1
De Luca, A.2
Tricarico, D.3
Roselli, A.4
Natuzzi, F.5
Ferrannini, E.6
Laico, M.7
Camerino, D.C.8
-
15
-
-
0032902622
-
Effects of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle
-
S. Pierno, A. De Luca, A. Liantonio, C. Camerino, and D. Conte Camerino Effects of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle Eur. J. Pharmacol. 364 1999 43 48
-
(1999)
Eur. J. Pharmacol.
, vol.364
, pp. 43-48
-
-
Pierno, S.1
De Luca, A.2
Liantonio, A.3
Camerino, C.4
Conte Camerino, D.5
-
16
-
-
0025818108
-
HMG-CoA reductase inhibitor-induced myopathy in the rat: Cyclosporine a interaction and mechanism studies
-
P.F. Smith, R.S. Eydelloth, S.J. Grossman, R.J. Stubbs, M.S. Schwartz, J.I. Germershausen, K.P. Vyas, P.H. Kari, and J.S. MacDonald HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies J. Pharmacol. Exp. Ther. 257 1991 1225 1235
-
(1991)
J. Pharmacol. Exp. Ther.
, vol.257
, pp. 1225-1235
-
-
Smith, P.F.1
Eydelloth, R.S.2
Grossman, S.J.3
Stubbs, R.J.4
Schwartz, M.S.5
Germershausen, J.I.6
Vyas, K.P.7
Kari, P.H.8
MacDonald, J.S.9
-
17
-
-
16644364657
-
Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions
-
H. Naba, C. Kuwayama, C. Kakinuma, S. Ohnishi, and T. Ogihara Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions Drug. Metab. Pharmacokinet. 19 2004 339 351
-
(2004)
Drug. Metab. Pharmacokinet.
, vol.19
, pp. 339-351
-
-
Naba, H.1
Kuwayama, C.2
Kakinuma, C.3
Ohnishi, S.4
Ogihara, T.5
-
18
-
-
0029149374
-
A new mutant rat with hyperbilirubinuria (hyb)
-
K. Yamazaki, T. Mikami, S. Hosokawa, O. Tagaya, Y. Nozaki, A. Kawaguchi, H. Funami, H. Katoh, N. Yamamoto, and T. Wakabayashi A new mutant rat with hyperbilirubinuria (hyb) J. Hered. 86 1995 314 317
-
(1995)
J. Hered.
, vol.86
, pp. 314-317
-
-
Yamazaki, K.1
Mikami, T.2
Hosokawa, S.3
Tagaya, O.4
Nozaki, Y.5
Kawaguchi, A.6
Funami, H.7
Katoh, H.8
Yamamoto, N.9
Wakabayashi, T.10
-
19
-
-
0030768373
-
The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes
-
D. Keppler, J. Konig, and M. Buchler The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes Adv. Enzyme Regul. 37 1997 321 333
-
(1997)
Adv. Enzyme Regul.
, vol.37
, pp. 321-333
-
-
Keppler, D.1
Konig, J.2
Buchler, M.3
-
20
-
-
0031031247
-
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
-
K. Ito, H. Suzuki, T. Hirohashi, K. Kume, T. Shimizu, and Y. Sugiyama Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR Am. J. Physiol. 272 1997 G16 G22
-
(1997)
Am. J. Physiol.
, vol.272
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kume, K.4
Shimizu, T.5
Sugiyama, Y.6
-
21
-
-
0029848514
-
Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinaemic rats
-
M. Yamazaki, K. Kobayashi, and Y. Sugiyama Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinaemic rats Biopharm. Drug Dispos. 17 1996 645 659
-
(1996)
Biopharm. Drug Dispos.
, vol.17
, pp. 645-659
-
-
Yamazaki, M.1
Kobayashi, K.2
Sugiyama, Y.3
-
22
-
-
0029999143
-
Pravastatin transport across the hepatocyte canalicular membrane requires both ATP and a transmembrane pH gradient
-
Y. Adachi, Y. Okuyama, H. Miya, H. Matsusita, M. Kitano, T. Kamisako, and T. Yamamoto Pravastatin transport across the hepatocyte canalicular membrane requires both ATP and a transmembrane pH gradient J. Gastroenterol. Hepatol. 11 1996 580 585
-
(1996)
J. Gastroenterol. Hepatol.
, vol.11
, pp. 580-585
-
-
Adachi, Y.1
Okuyama, Y.2
Miya, H.3
Matsusita, H.4
Kitano, M.5
Kamisako, T.6
Yamamoto, T.7
-
23
-
-
0030862073
-
Biliary excretion of pravastatin in rats: Contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter
-
M. Yamazaki, S. Akiyama, K. Ni'inuma, R. Nishigaki, and Y. Sugiyama Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter Drug Metab. Dispos. 25 1997 1123 1129
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 1123-1129
-
-
Yamazaki, M.1
Akiyama, S.2
Ni'Inuma, K.3
Nishigaki, R.4
Sugiyama, Y.5
-
24
-
-
0031913403
-
Effects of organic anions and bile acid conjugates on biliary excretion of pravastatin in the rat
-
S. Fukumura, H. Takikawa, and M. Yamanaka Effects of organic anions and bile acid conjugates on biliary excretion of pravastatin in the rat Pharm. Res. 15 1998 72 76
-
(1998)
Pharm. Res.
, vol.15
, pp. 72-76
-
-
Fukumura, S.1
Takikawa, H.2
Yamanaka, M.3
-
25
-
-
0026048618
-
Marked hypokalemic rhabdomyolysis with myoglobinuria due to diuretic treatment
-
S. Shintani, T. Shiigai, and H. Tsukagoshi Marked hypokalemic rhabdomyolysis with myoglobinuria due to diuretic treatment Eur. Neurol. 31 1991 396 398
-
(1991)
Eur. Neurol.
, vol.31
, pp. 396-398
-
-
Shintani, S.1
Shiigai, T.2
Tsukagoshi, H.3
-
26
-
-
3042854513
-
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme a reductase inhibitors
-
S.M. Jamal, M.J. Eisenberg, and S. Christopoulos Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors Am. Heart J. 147 2004 956 965
-
(2004)
Am. Heart J.
, vol.147
, pp. 956-965
-
-
Jamal, S.M.1
Eisenberg, M.J.2
Christopoulos, S.3
-
27
-
-
0025242794
-
Lovastatin decreases coenzyme Q levels in humans
-
K. Folkers, P. Langsjoen, R. Willis, P. Richardson, L.J. Xia, C.Q. Ye, and H. Tamagawa Lovastatin decreases coenzyme Q levels in humans Proc. Natl. Acad. Sci. USA 87 1990 8931 8934
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 8931-8934
-
-
Folkers, K.1
Langsjoen, P.2
Willis, R.3
Richardson, P.4
Xia, L.J.5
Ye, C.Q.6
Tamagawa, H.7
-
28
-
-
0029837064
-
Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio
-
G. De Pinieux, P. Chariot, M. Ammi-Said, F. Louarn, J.L. Lejonc, A. Astier, B. Jacotot, and R. Gherardi Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio Br. J. Clin. Pharmacol. 42 1996 333 337
-
(1996)
Br. J. Clin. Pharmacol.
, vol.42
, pp. 333-337
-
-
De Pinieux, G.1
Chariot, P.2
Ammi-Said, M.3
Louarn, F.4
Lejonc, J.L.5
Astier, A.6
Jacotot, B.7
Gherardi, R.8
-
29
-
-
0032494101
-
3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
-
C. Guijarro, L.M. Blanco-Colio, M. Ortego, C. Alonso, A. Ortiz, J.J. Plaza, C. Diaz, G. Hernandez, and J. Egido 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture Circ. Res. 83 1998 490 500
-
(1998)
Circ. Res.
, vol.83
, pp. 490-500
-
-
Guijarro, C.1
Blanco-Colio, L.M.2
Ortego, M.3
Alonso, C.4
Ortiz, A.5
Plaza, J.J.6
Diaz, C.7
Hernandez, G.8
Egido, J.9
-
30
-
-
0035834374
-
Tyrosine phosphorylation of the catalytic subunit p110 of phosphatidylinositol-3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in L6 myoblasts
-
H. Nakagawa, T. Mutoh, T. Kumano, and M. Kuriyama Tyrosine phosphorylation of the catalytic subunit p110 of phosphatidylinositol-3 kinase induced by HMG-CoA reductase inhibitor inhibits its kinase activity in L6 myoblasts FEBS Lett. 508 2001 53 56
-
(2001)
FEBS Lett.
, vol.508
, pp. 53-56
-
-
Nakagawa, H.1
Mutoh, T.2
Kumano, T.3
Kuriyama, M.4
-
31
-
-
0026467795
-
Experimental evaluation of the effects of pravastatin on electrophysiological parameters of rat skeletal muscle
-
S. Pierno, A. De Luca, D. Tricarico, E. Ferrannini, T. Conte, G. D'Alo, and D.C. Camerino Experimental evaluation of the effects of pravastatin on electrophysiological parameters of rat skeletal muscle Pharmacol. Toxicol. 71 1992 325 329
-
(1992)
Pharmacol. Toxicol.
, vol.71
, pp. 325-329
-
-
Pierno, S.1
De Luca, A.2
Tricarico, D.3
Ferrannini, E.4
Conte, T.5
D'Alo, G.6
Camerino, D.C.7
-
32
-
-
0034802547
-
Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine a and sirolimus (Rapamycin)
-
S. Bramow, P. Ott, F. Thomsen Nielsen, K. Bangert, N. Tygstrup, and K. Dalhoff Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine A and sirolimus (Rapamycin) Pharmacol. Toxicol. 89 2001 133 139
-
(2001)
Pharmacol. Toxicol.
, vol.89
, pp. 133-139
-
-
Bramow, S.1
Ott, P.2
Thomsen Nielsen, F.3
Bangert, K.4
Tygstrup, N.5
Dalhoff, K.6
-
33
-
-
0038209381
-
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
-
Y. Nishizato, I. Ieiri, H. Suzuki, M. Kimura, K. Kawabata, T. Hirota, H. Takane, S. Irie, H. Kusuhara, Y. Urasaki, A. Urae, S. Higuchi, K. Otsubo, and Y. Sugiyama Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics Clin. Pharmacol. Ther. 73 2003 554 565
-
(2003)
Clin. Pharmacol. Ther.
, vol.73
, pp. 554-565
-
-
Nishizato, Y.1
Ieiri, I.2
Suzuki, H.3
Kimura, M.4
Kawabata, K.5
Hirota, T.6
Takane, H.7
Irie, S.8
Kusuhara, H.9
Urasaki, Y.10
Urae, A.11
Higuchi, S.12
Otsubo, K.13
Sugiyama, Y.14
-
34
-
-
18244401389
-
A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy
-
K. Morimoto, T. Oishi, S. Ueda, M. Ueda, M. Hosokawa, and K. Chiba A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy Drug Metab. Pharmacokinet. 19 2004 453 455
-
(2004)
Drug Metab. Pharmacokinet.
, vol.19
, pp. 453-455
-
-
Morimoto, K.1
Oishi, T.2
Ueda, S.3
Ueda, M.4
Hosokawa, M.5
Chiba, K.6
|