Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse

Journal of Hepatology

Volumn 44, Issue 1, 2006, Pages 176-182

  Chua, Anita C G ^a   Drake, Sarah F ^a   Herbison, Carly E ^a   Olynyk, John K ^a,b   Leedman, Peter J ^c   Trinder, Debbie ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Ferroportin; Hereditary haemochromatosis; Iron release; Liver; Nontransferrin bound iron

Indexed keywords

FERROPORTIN 1; IRON;

ANIMAL CELL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEMOCHROMATOSIS; INCUBATION TIME; IRON KINETICS; IRON OVERLOAD; IRON TRANSPORT; KNOCKOUT MOUSE; LIVER CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; BLOTTING, WESTERN; CATION TRANSPORT PROTEINS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; HEMOCHROMATOSIS; HEPATOCYTES; IRON; MALE; MICE; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 28844506080     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.08.012     Document Type: Article

References (23)

1. J.K. Olynyk Hereditary haemochromatosis: diagnosis and management in the gene era Liver 19 1999 73 80
2. J.K. Olynyk, and B.R. Bacon Hereditary hemochromatosis. Detecting and correcting iron overload Postgrad Med 96 1994 151 158 [161, 165]
3. E. Baker, S.M. Baker, and E.H. Morgan Characterisation of non-transferrin-bound iron (ferric citrate) uptake by rat hepatocytes in culture Biochim Biophys Acta 1380 1998 21 30
4. R.M. Graham, E.H. Morgan, and E. Baker Characterisation of citrate and iron citrate uptake by cultured rat hepatocytes J Hepatol 29 1998 603 613
5. D. Trinder, and E. Morgan Mechanisms of ferric citrate uptake by human hepatoma cells Am J Physiol 275 1998 G279 G286
6. A.C.G. Chua, J.K. Olynyk, P.J. Leedman, and D. Trinder Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis Blood 104 2004 1519 1525
7. A.C.G. Chua, H.A. Ingram, K.N. Raymond, and E. Baker Multidentate pyridinones inhibit the metabolism of nontransferrin-bound iron by hepatocytes and hepatoma cells Eur J Biochem 270 2003 1689 1698
8. E. Baker, M. Page, and E.H. Morgan Transferrin and iron release from rat hepatocytes in culture Am J Physiol 248 1985 G93 G97
9. E. Baker, D. Trinder, J. Torrance, M. Page, and E.H. Morgan Characteristics of iron exchange between transferrin and hepatocytes in culture Birth Defects Orig Artic Ser 23 1988 41 47
10. E. Baker, F.R. Vicary, and E.R. Huehns Iron release from isolated hepatocytes Br J Haematol 47 1981 493 504
11. Z.L. Harris, A.P. Durley, T.K. Man, and J.D. Gitlin Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux Proc Natl Acad Sci USA 96 1999 10812 10817
12. A. Donovan, A. Brownlie, Y. Zhou, J. Shepard, S.J. Pratt, and J. Moynihan Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Nature 403 2000 776 781
13. A.T. McKie, P. Marciani, A. Rolfs, K. Brennan, K. Wehr, and D. Barrow A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation Mol Cell 5 2000 299 309
14. S. Abboud, and D.J. Haile A novel mammalian iron-regulated protein involved in intracellular iron metabolism J Biol Chem 275 2000 19906 19912
15. X.Y. Zhou, S. Tomatsu, R.E. Fleming, S. Parkkila, A. Waheed, and J. Jiang HFE gene knockout produces mouse model of hereditary hemochromatosis Proc Natl Acad Sci USA 95 1998 2492 2497
16. J.N. Octave, Y.J. Schneider, R.R. Crichton, and A. Trouet Iron mobilization from cultured hepatocytes: effect of desferrioxamine B Biochem Pharmacol 32 1983 3413 3418
17. S.P. Young, M. Fahmy, and S. Golding Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells FEBS Lett 411 1997 93 96
18. M.D. Knutson, M.R. Vafa, D.J. Haile, and M. Wessling-Resnick Iron loading and erythrophagocytosis increase ferroportin 1 (Fpn1) expression in J774 macrophages Blood 102 2003 4191 4197
19. J. Chung, D.J. Haile, and M. Wessling-Resnick Copper-induced ferroportin-1 expression in J774 macrophages is associated with increased iron efflux Proc Natl Acad Sci USA 101 2004 2700 2705
20. X.B. Liu, P. Hill, and D.J. Haile Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation Blood Cells Mol Dis 29 2002 315 326
21. A. Lymboussaki, E. Pignatti, G. Montosi, C. Garuti, D.J. Haile, and A. Pietrangelo The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression J Hepatol 39 2003 710 715
22. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, and D.M. Ward Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090 2093
23. G. Cairo, S. Recalcati, G. Montosi, E. Castrusini, D. Conte, and A. Pietrangelo Inappropriately high iron regulatory protein activity in monocytes of patients with genetic hemochromatosis Blood 89 1997 2546 2553