Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3′ allyl end and at the phenyl ring of the cinnamyl chain on μ-receptor affinity and opioid antinociception

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 18, 2003, Pages 4015-4026

  Pinna, Gérard Aimè ^a   Cignarella, Giorgio ^b   Ruiu, Stefania ^c   Loriga, Giovanni ^a,c   Murineddu, Gabriele ^a,c   Villa, Stefania ^b   Grella, Giuseppe Enrico ^a   Cossu, Gregorio ^d   Fratta, Walter ^d  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c Neuroscienze PharmaNess Scarl   (Italy)

^d UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 PROPIONYL 7 (3' CYCLOHEXYL 3' PHENYLPROP 2' EN 1' YL) 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 (3' DIPHENYLPROP 2' EN 1' YL) 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 (3' PHENYL 3' METHYLPROP 2' EN 1' YL) 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 (3' TRIFLUOROMETHYL 3' PHENYLPROP 2' EN 1' YL) 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 CINNAMYL 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 [3' METHYL 3' (2 CHLOROPHENYL)PROP 2' EN 1' YL] 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 [3' METHYL 3' (2,4 DICHLOROPHENYL)PROP 2' EN 1' YL] 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 [3' METHYL 3' (3 CHLOROPHENYL)PROP 2' EN 1' YL] 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 [3' METHYL 3' (3,4 DICHLOROPHENYL)PROP 2' EN 1' YL] 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 2 PROPIONYL 7 [3' METHYL 3' (4 CHLOROPHENYL)PROP 2' EN 1' YL] 2,7 DIAZATRICYCLO[4.4.0.0 3,8 ]DECANE; 9 PROPIONYL 10 (3' CYCLOHEXYL 3' PHENYLPROP 2' EN 1' YL) 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 (3' PHENYL 3' METHYLPROP 2' EN 1' YL) 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 (3' TRIFLUOROMETHYL 3' PHENYLPROP 2' EN 1' YL) 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 (3',3' DIPHENYLPROP 2' EN 1' YL) 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 CINNAMYL 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 [(3',3' DI 4 CHLOROPHENYL)PROP 2' EN 1' YL] 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 [(3',3' DI 4 FLUOROPHENYL)PROP 2' EN 1' YL] 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 [3' METHYL 3' (2 CHLOROPHENYL)PROP 2' EN 1' YL] 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 [3' METHYL 3' (2,4 DICHLOROPHENYL)PROP 2' EN 1' YL] 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 [3' METHYL 3' (3 CHLOROPHENYL)PROP 2' EN 1' YL] 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 [3' METHYL 3' (3,4 DICHLOROPHENYL)PROP 2' EN 1' YL] 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; 9 PROPIONYL 10 [3' METHYL 3' (4 CHLOROPHENYL)PROP 2' EN 1' YL] 9,10 DIAZATRICYCLO[4.2.1.1 2,5 ]DECANE; ADAMANTANE DERIVATIVE; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; OPIATE; PHENYL GROUP; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DRUG BINDING; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; HOT PLATE TEST; MOUSE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0041589245     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00373-0     Document Type: Article

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