Benzocondensed derivatives as rigid analogues of the μ-opioid agonist 3(8)-cinnamyl-8(3)-propionyl-3,8-diazabicyclo[3,2,1]octanes: Synthesis, modeling, and affinity

Farmaco

Volumn 53, Issue 10-11, 1998, Pages 667-674

  Cignarella, G ^a   Barlocco, D ^a   Vianello, P ^a   Villa, S ^a   Pinna, G A ^b   Fadda, P ^c   Fratta, W ^c   Toma, L ^d   Gessi, S ^e  

^a Istituto di Chimica Farmaceutica e Tossicologica   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c Dipartimento di Neuroscienze   (Italy)

^d Dipartimento di Chimica   (Italy)

^e Istituto di Farmacologia   (Italy)

Author keywords

Analgesic activity; Diazabicyclooctanes; Opioid receptors

Indexed keywords

3 CINNAMYL 8 PROPIONYL 3,8 DIAZABICYCLO[3.2.1]OCTANE; ANALGESIC AGENT; BENZENE DERIVATIVE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; MOLECULAR MODEL; RECEPTOR AFFINITY;

ANALGESICS, OPIOID; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; MALE; MICE; MODELS, CHEMICAL; MOLECULAR CONFORMATION; OCTANES; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032453580     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(98)00084-6     Document Type: Article

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