Streptococcal pyrogenic exotoxin B induces apoptosis and reduces phagocytic activity in U937 cells

Infection and Immunity

Volumn 67, Issue 1, 1999, Pages 126-130

  Kuo, Chih Feng ^a   Wu, Jiunn Jong ^a   Tsai, Pei Jane ^a   Kao, Fu Jen ^b   Lei, Huan Yao ^a   Lin, Ming T ^a   Lin, Yee Shin ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; EXOTOXIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA DETERMINATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; STREPTOCOCCUS PYOGENES; TOXICITY TESTING; TOXIN ANALYSIS;

STREPTOCOCCUS PYOGENES;

EID: 0032894568     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.1.126-130.1999     Document Type: Article

References (34)

1. Burns, E. H., Jr., A. M. Marciel, and J. M. Musser. 1996. Activation of a 66-kilodalton human endothelial cell matrix metalloprotease by Streptococcus pyogenes extracellular cysteine protease. Infect. Immun. 64:4744-4750.
2. Chaussee, M. S., D. Gerlach, C. E. Yu, and J. J. Ferretti. 1993. Inactivation of the streptococcal erythrogenic toxin B gene (speB) in Streptococcus pyogenes. Infect. Immun. 61:3719-3723.
3. Chen, L. M., K. Kaniga, and J. E. Galan. 1996. Salmonella spp. are cytotoxic for cultured macrophages. Mol. Microbiol. 21:1101-1115.
4. Chen, Y., M. R. Smith, K. Thirumalai, and A. Zychlinsky. 1996. A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J. 15:3853-3860.
5. Hanna, P. C., D. Acosta, and R. J. Collier. 1993. On the role of macrophages in anthrax. Proc. Natl. Acad. Sci. USA 90:10198-10201.
6. Hermant, D., R. Menard, N. Arricau, C. Parsot, and M. Y. Popoff. 1995. Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells. Mol. Microbiol. 17:781-789.
7. Holm, S. E., A. Norrby, A. M. Bergholm, and M. Norgren. 1992. Aspects of pathogenesis of serious group A streptococcal infections in Sweden, 1988-1989. J. Infect. Dis. 166:31-37.
8. Hsueh, P. R., J. J. Wu, P. J. Tsai, J. W. Liu, Y. C. Chuang, and K. T. Luh. 1998. Invasive group A streptococcal disease in Taiwan is not associated with the presence of streptococcal pyrogenic exotoxin genes. Clin. Infect. Dis. 26:584-589.
9. Hueck, C. J., M. J. Hantman, V. Bajaj, C. Johnston, C. A. Lee, and S. I. Miller. 1995. Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins. Mol. Microbiol. 18:479-490.
10. Kaniga, K., S. Tucker, D. Trollinger, and J. E. Galan. 1995. Homologs of the shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. J. Bacteriol. 177:3965-3971.
11. Kapur, V., M. W. Majesky, L. L. Li, R. A. Black, and J. M. Musser. 1993. Cleavage of interleukin 1β (IL-1β) precursor to produce active IL-1β by a conserved extracellular cysteine protease from Streptococcus pyogenes. Proc. Natl. Acad. Sci. USA 90:7676-7680.
12. Kapur, V., S. Topouzis, M. W. Majesky, L. L. Li, M. R. Hamrick, R. J. Hamill, J. M. Patti, and J. M. Musser. 1993. A conserved Streptococcus pyogenes extracellular cysteine protease cleaves human fibronectin and degrades vitronectin. Microb. Pathog. 15:327-346.
13. Kochi, S. K., and R. J. Collier. 1993. DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis. Exp. Cell Sci. 208:296-302.
14. Kuo, C.-F., J.-J. Wu., K.-Y. Lin, P.-J. Tsai, S.-C. Lee, Y.-T. Jin, H.-Y. Lei, and Y.-S. Lin. 1998. Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection. Infect. Immun. 66:3931-3935.
15. Lin, Y.-S., H.-Y. Lei, T. L. K. Low, C.-L. Shen, L.-J. Chou, and M.-S. Jan. 1992. In vivo induction of apoptosis in immature thymocytes by staphylococcal enterotoxin B. J. Immunol. 149:1156-1163.
16. Lindgren, S. W., I. Stojilkovic, and F. Heffron. 1996. Macrophage killing is an essential virulence mechanism of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 93:4197-4201.
17. Lukomski, S., S. Sreevatsan, C. Amberg, W. Reichardt, M. Woischnik, A. Podbielski, and J. M. Musser. 1997. Inactivation of Streptococcus pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains. J. Clin. Invest. 99:2574-2580.
18. Lukomski, S., E. H. Burns, Jr., P. R. Wyde, A. Podbielski, J. Rurangirwa, D. K. Moore-Poveda, and J. M. Musser. 1998. Genetic inactivation of an extracellular cysteine protease (SpeB) expressed by Streptococcus pyogenes decreases resistance to phagocytosis and dissemination to organs. Infect. Immun. 66:771-776.
19. Monack, D. M., J. Mecsas, N. Ghori, and S. Falkow. 1997. Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death. Proc. Natl. Acad. Sci. USA 94:10385-10390.
20. Monack, D. M., B. Raupach, A. E. Hromockyj, and S. Falkow. 1996. Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc. Natl. Acad. Sci. USA 93:9833-9838.
21. Murray, D. L., D. H. Ohlendorf, and P. M. Schlievert. 1995. Staphylococcal and streptococcal superantigens: their role in human diseases. ASM News 61:229-235.
22. Ohara-Nemoto, Y., M. Sasaki, M. Kaneko, T. Nemoto, and M. Ota. 1994. Cysteine protease activity of streptococcal pyrogenic exotoxin B. Can. J. Microbiol. 40:930-936.
23. Ruckdeschel, K., A. Roggenkamp, V. Lafont, P. Mangeat, J. Heesemann, and B. Rouot. 1997. Interaction of Yersinia enterocolitica with macrophages leads to macrophage cell death through apoptosis. Infect. Immun. 65:4813-4821.
24. Spencer, R. C. 1995. Invasive streptococci. Eur. J. Clin. Microbiol. Infect. Dis. 14(Suppl.):S26-S32.
25. Stevens, D. L. 1992. Invasive group A streptococcus infections. Clin. Infect. Dis. 14:2-13.
26. Tsai, P.-J., C.-F. Kuo, K.-Y. Lin, Y.-S. Lin, H.-Y. Lei, F.-F. Chen, J.-R. Wang, and J.-J. Wu. 1998. Effect of group A streptococcal cysteine protease on invasion of epithelial cells. Infect. Immun. 66:1460-1466.
27. Tsai, P.-J., C.-F. Kuo, Y.-S. Lin, and J.-J. Wu. Unpublished data.
28. Tsao, C.-W., J.-T. Cheng, C.-L. Shen, and Y.-S. Lin. 1996. 6-Hydroxydopamine induces thymocyte apoptosis in mice. J. Neuroimmunol. 65:91-95.
29. Wheeler, M. C., M. H. Roe, E. L. Kaplan, P. M. Schlievert, and J. K. Todd. 1991. Outbreak of group A streptococcus septicemia in children: clinical, epidemiologic, and microbiological correlates. JAMA 266:533-537.
30. Wolf, B. B., C. A. Gibson, V. Kapur, I. M. Hussaini, J. M. Musser, and S. L. Gonias. 1994. Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface. J. Biol. Chem. 269:30682-30687.
31. Zychlinsky, A., C. Fitting, J.-M. Cavaillon, and P. J. Sansonetti. 1994. Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri. J. Clin. Invest. 94:1328-1332.
32. Zychlinsky, A., M. C. Prevost, and P. J. Sansonetti. 1992. Shigella flexneri induces apoptosis in infected macrophages. Nature 358:167-169.
33. Zychlinsky, A., and P. Sansonetti. 1997. Apoptosis in bacterial pathogenesis. J. Clin. Invest. 100:S63-S65.
34. Zychlinsky, A., K. Thirumalai, J. Arondel, J. R. Cantey, A. O. Aliprantis, and P. J. Sansonetti. 1996. In vivo apoptosis in Shigella flexneri infections. Infect. Immun. 64:5357-5365.