Streptococcal inhibitor of complement (SIC) inhibits the membrane attack complex by preventing uptake of C567 onto cell membranes

Immunology

Volumn 103, Issue 3, 2001, Pages 390-398

  Fernie King, Barbara A ^a   Seilly, David J ^a   Willers, Christine ^a   Würzner, Reinhard ^b   Davies, Alexandra ^a   Lachmann, Peter J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CLUSTERIN; COMPLEMENT; COMPLEMENT MEMBRANE ATTACK COMPLEX; POLYCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; COMPLEMENT INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; ESCHERICHIA COLI; HEMOLYSIS; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOCOCCUS PYOGENES;

EID: 0034937066     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01249.x     Document Type: Article

References (26)

1. Group A streptococci in the 1990s
2. Complement and innate immunity
3. Evasion of pathogens by avoiding recognition or eradication by complement, in part via molecular mimicry
4. Antiphagocytic activity of streptococcal M protein: Selective binding of complement control protein factor H
5. Role of the hypervariable region in streptococcal M proteins: Binding of a human complement inhibitor
6. Ig-binding surface proteins of Streptococcus pyogenes also bind human C4b-binding protein (C4bp), a regulatory component of the complement system
7. Streptococcal C5a peptidase is a highly specific endopeptidase
8. Protein SIC, a novel extracellular protein of Streptococcus pyogenes interfering with complement function
9. Streptococcus pyogenes strains containing emm12 and emm55 possess a novel gene coding for distantly related SIC protein
10. Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta and the b domain of C9
11. Regulation of complement functional efficiency by histidine-rich glycoprotein
12. Nonpolar inactivation of the hypervariable streptococcal inhibitor of complement gene (SIC) in serotype M1 Streptococcus pyogenes significantly decreases mouse mucosal colonization
13. The membrane attack complex inhibitor of Streptococcus pyogenes (SIC) binds preferentially to C567
14. Selection of group A streptococci rich in M-protein from populations poor in M-protein
15. Characterization of Group A Streptococcus strains recovered from Mexican children with pharyngitis by automated DNA sequencing of virulence-related genes: Unexpectedly large variation in the gene (SIC) encoding a complement-inhibiting protein
16. Detection of specific sequences among DNA fragments separated by gel electrophoresis
17. 125I using intensifying screens and hypersensitized film
18. Assessment of the interaction of human complement regulatory proteins with group A Streptococcus. Identification of a high-affinity group A Streptococcus binding site in FHL-1
19. Complement technology
20. The preparation and characterization of monoclonal antibodies to human complement component C8 and their use in purification of C8 and C8 subunits
21. Immunoaffinity purification of human complement component C9 using monoclonal antibodies
22. Functionally active complement proteins C6 and C7 detected in C6- and C7-deficient individuals
23. Restriction of complement-mediated membrane damage by the eighth component of complement: A dual role for C8 in the complement attack sequence
24. Inhibition of alternative complement pathway opsonization by group A streptococcal M protein