Development of E3-substrate (MDM2-p53)-binding inhibitors: Structural aspects

Methods in Enzymology

Volumn 399, Issue , 2005, Pages 622-633

  Fry, David C ^a   Graves, Bradford ^a   Vassilev, Lyubomir T ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGASE; PROTEIN MDM2; PROTEIN P53;

BINDING AFFINITY; CRYSTAL STRUCTURE; HIGH THROUGHPUT SCREENING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION; REVIEW; STRUCTURE ANALYSIS; UBIQUITINATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-MDM2; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 28844484583     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(05)99041-1     Document Type: Review

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