Novel synthetic polyamines are effective in the treatment of experimental microsporidiosis, an opportunistic AIDS-associated infection

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 1, 2002, Pages 55-61

  Bacchi, C J ^a   Weiss, L M ^a   Lane, S ^a   Frydman, B ^a   Valasinas, A ^a   Reddy, V ^a   Sun, J S ^a   Marton, L J ^a   Khan, I A ^a   Moretto, M ^a   Yarlett, N ^a   Wittner, M ^a  

^a PACE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; POLYAMINE DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENCEPHALITOZOON CUNICULI; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CELL CULTURE; KNOCKOUT MOUSE; MICROSPORIDIOSIS; MICROSPORUM; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; OPPORTUNISTIC INFECTION; PARASITEMIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TREATMENT OUTCOME;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANIMALS; DISEASE MODELS, ANIMAL; ENCEPHALITOZOON CUNICULI; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; MICROSPORIDIOSIS; PARASITIC SENSITIVITY TESTS; POLYAMINES; TREATMENT OUTCOME;

EID: 0036137012     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.1.55-61.2002     Document Type: Article

References (44)

1. Polyamine synthesis and interconversion by the microsporidian Encephalitozoon cuniculi
2. The complete atomic structure of the large ribosomal subunit at 2.4 Å resolution
3. Interaction of a polyamine analogue, 1.19-bis-(ethylamino)-5, 10-15-triazanonadecane (BE-4-4-4-4), with DNA and effect on growth, survival, and polyamine levels in seven human brain tumor cell lines
4. Effects of spermine and its cytotoxic analogues on nucleosome formation in topologically stressed DNA in vitro
5. Hydrogen bonding interactions of polyamines with the 2'OH of RNA
6. TNP-470 is an effective antimicrosporidial agent
7. Epidemiology and zoonotic aspects of microsporidia of mammals and birds
8. Experimental microsporidiosis in immunocompetent and immunodeficient mice and monkeys
9. Treatment with albendazole for intestinal disease due to Enterocytozoon bieneusi in patients with AIDS
10. Implications and concepts of polyamine-nucleic acid interactions
11. Susceptibility of Encephalitozoon cuniculi to several drugs in vitro
12. Polyamine-based chemotherapy of cancer
13. 1H-NMR analysis
14. 1H-NMR and its possible correlation with cell cycling and cytotoxicity
15. 15N-NMR study
16. Intestinal parasites in patients with diarrhea and human immunodeficiency virus infection in Zimbabwe
17. + CTLs are essential for protective immunity against Encephalitozoon infection
18. Antiprotozoal activities of benzimidazoles and correlations with β-tubulin sequence
19. Measurement of the efficacy of vaccines and antimicrobial therapy against infection with Toxoplasma gondii
20. Clinical syndromes associated with microsporidosis
21. Synthesis and antitumor evaluation of a highly potent cytotoxic DNA cross-linking polyamine analogue, 1,12-diaziridinyl-4,9-diazadodecane
22. Polyamines as targets for therapeutic intervention
23. A case of an encephalitozoon-like body in man
24. Potential efficacy of fumagillin in intestinal microsporidiosis due to Enterocytozoon bieneusi in patients with HIV infection: Results of a drug screening study
25. + T-cell immunity against Encephalitozoon cuniculi infection
26. The structural basis of ribosome activity in peptide bond synthesis
27. Polyamine induced aggregation of DNA
28. Microsporidial keratitis
29. cis-Unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4): Synthesis and growth inhibitory effects on human prostate cancer cell lines
30. 12N-bisethylspermine: Synthesis and growth inhibitory effects on human tumor cells
31. 13C] source
32. Systematics of microsporidia
33. The effect of isolation conditions on the polyamine content of Escherichia coli ribosomes
34. On the melting temperature of nucleic acid in solution
35. 14N-bisethylhomospermine (BE-4-4-4): Synthesis and growth inhibitory effects on human prostate cancer cells
36. Microsporidian spores in the stool specimens of toddlers with or without diarrhea from Tucuman, Argentin
37. Property-based design: Optimization of drug absorption and pharmacokinetics
38. Structure of the microsporidia
39. Human microsporidial infections
40. The activity of albendazole against Encephalitozoon cuniculi
41. Parasitic infections in AIDS patients: Cryptosporidiosis, isopsoriasis, microsporidosis, cyclosporiasis